Rifaximin medicine composition and preparation method thereof

A technology of rifaximin and its composition, which is applied in the field of pharmaceutical composition and its preparation, can solve the problem that the pathogenesis of hepatic encephalopathy is not completely clear, and achieve the effect of rapid disintegration, uniform dispersion and fast dissolution

Inactive Publication Date: 2013-10-09
WORLDCO INT
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Problems solved by technology

The pathogenesis of hepatic encephalopathy is not fully understood

Method used

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  • Rifaximin medicine composition and preparation method thereof
  • Rifaximin medicine composition and preparation method thereof

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Embodiment Construction

[0020] Specific embodiments of the present invention will be described in detail below.

[0021] The pharmaceutical composition of rifaximin provided by the present invention comprises the following components: 40%-60% of rifaximin by mass percentage, 10%-50% of microcrystalline cellulose, 1%-30% of carboxyl Sodium methyl starch or cross-linked sodium carboxymethyl starch, 0.5%-6% silicon dioxide, 0.5%-6% stearic acid, and a trace amount of hydroxypropyl cellulose aqueous solution with a mass concentration of 0.5%-6% . Preferably 45%-55% rifaximin, 20%-40% microcrystalline cellulose, 5%-20% sodium carboxymethyl starch or cross-linked sodium carboxymethyl starch, 1%-5% Silicon dioxide, 1%-3% stearic acid, and a trace amount of hydroxypropyl cellulose aqueous solution with a mass concentration of 1%-3%. Most preferably be 55% rifaximin by mass percentage, 30% microcrystalline cellulose, 10% sodium carboxymethyl starch, 3% silicon dioxide, 2% stearic acid, and mass concentratio...

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Abstract

The invention discloses a rifaximin medicine composition and a preparation method of the rifaximin medicine composition. The rifaximin medicine composition comprises the following ingredients in percentages by mass: 40-60% of rifaximin, 10-50% of microcrystalline cellulose, 1-30% of sodium carboxymethyl starch or sodium carboxymethyl starch, 0.5-6% of silicon dioxide, 0.5-6% of stearic acid and a little amount of aqueous solution of hydroxy propyl cellulose with the mass concentration of 0.5-6%. The medicine composition can be made into tablets and capsules, each dose comprises 550mg of rifaximin respectively, and a coating solution for the preparation is an aqueous solution of opadry with the mass concentration of 5-30%. The invention also provides the preparation method of the rifaximin medicine composition. According to the rifaximin medicine composition and the preparation method of the rifaximin medicine composition disclosed by the invention, the preparation of the medicine composition can be rapidly disintegrated to fully take medicine efficacy, so as to improve the health of a patient suffering from liver cirrhosis recurrent hepatic encephalopathy.

Description

technical field [0001] The invention relates to a pharmaceutical composition and a preparation method thereof, in particular to a rifaximin pharmaceutical composition and a preparation method thereof. Background technique [0002] Rifaximin is a gut antibiotic that is a derivative of rifamycin. The biggest feature is that it is not absorbed in the gastrointestinal tract after oral administration, has strong antibacterial effect and wide antibacterial spectrum. Compared with aminoglycoside antibiotics, this product is effective against Staphylococcus aureus in Gram-positive aerobic bacteria, Staphylococcus epidermidis and Enterococcus, and Clostridium difficile in Gram-positive anaerobic bacteria. Highly active, while the activity of aminoglycoside antibiotics against the above-mentioned bacteria is very low or very low. Rifaximin is also highly active against Bacteroides, while aminoglycosides are not. The adverse reaction of rifaximin is far lower than that of aminoglyco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/437A61K47/38A61P1/16A61P25/00
Inventor 林荣锦杨大龙谢浩唐晔盛魏彦韫姚雅童
Owner WORLDCO INT
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