Method for improving fermentation yield of hyaluronic acid
A technology for hyaluronic acid and yield, which is applied in the field of improving hyaluronic acid fermentation yield, can solve problems such as product quality decline, limited application, easy to break hyaluronic acid molecules, etc., and achieves the effect of cost reduction
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Embodiment 1
[0027] Streptococcus zooepidemicus was used as hyaluronic acid fermentation strain. Add ferrous ammonium sulfate and copper ammonium sulfate to the medium used in the traditional method. The amount of ammonium ferrous sulfate added is 0.01% of the mass of the medium, and the amount of ammonium copper sulfate added is 0.05% of the mass of the medium.
[0028] The yield of hyaluronic acid was 1.37g / L, and the yield increased by about 30.4%.
Embodiment 2
[0030] Streptococcus zooepidemicus was used as hyaluronic acid fermentation strain. Ferrous ammonium sulfate and copper ammonium sulfate were added to the medium used. The amount of ammonium ferrous sulfate added is 0.1% of the mass of the medium, and the amount of ammonium copper sulfate added is 0.1% of the mass of the medium.
[0031] The yield of hyaluronic acid was 1.40g / L, and the yield increased by about 33.3%.
Embodiment 3
[0033] Streptococcus zooepidemicus was used as hyaluronic acid fermentation strain. Ferrous ammonium sulfate and copper ammonium sulfate were added to the medium used. The amount of ammonium ferrous sulfate added is 0.05% of the mass of the medium, and the amount of ammonium copper sulfate added is 0.03% of the mass of the medium.
[0034] The yield of hyaluronic acid was 1.41g / L, and the yield increased by about 34.2%.
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