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Graphene field-effect transistor biosensor as well as manufacturing method and detecting method thereof

A biosensor and field effect tube technology, applied in the field of analytical chemistry, can solve the problems of inconvenient measurement of biosensors, affect the sensitivity of detection signals, reduce signal strength, etc., to expand the detection range of samples, improve detection sensitivity and detection range, reduce Effect of small contact resistance

Inactive Publication Date: 2013-11-20
SHANDONG NORMAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] (1) The Ag / AgCl electrode is separated from the graphene FET, which is not suitable for the integration of biosensors into a single device and is not easy to measure
[0006] (2) Due to the residual PMMA on the surface of graphene, the contact resistance between silver paint and graphene is relatively large, which will reduce the signal strength and thus affect the sensitivity of the detection signal

Method used

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  • Graphene field-effect transistor biosensor as well as manufacturing method and detecting method thereof
  • Graphene field-effect transistor biosensor as well as manufacturing method and detecting method thereof
  • Graphene field-effect transistor biosensor as well as manufacturing method and detecting method thereof

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Embodiment Construction

[0043] The present invention is described in detail below in conjunction with accompanying drawing:

[0044] Such as figure 1 As shown, a graphene field effect tube biosensor includes a glass substrate, both sides of the glass substrate are provided with ITO, part of the glass substrate on the same side and the top of the ITO are covered with graphene, and the glass substrate and the ITO are not covered with graphene. The ITO on both sides is located on the same side, and the ITO on both sides not covered with graphene is the source and drain respectively. The ITO covered with graphene is covered with a PET gasket, and the PET gasket is covered with a sputtered gold film. PET substrate, using insulating silica gel to set a sample pool in the middle of the glass substrate, and the gold film as the grid.

[0045] The size of the glass substrate not covered with graphene and the ITO on both sides are 2mm*10mm and 2mm*5mm respectively; the size of the sample cell is: 18mm*10mm*2m...

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Abstract

The invention discloses a graphene field-effect transistor biosensor as well as a manufacturing method and a detecting method thereof. The graphene field-effect transistor biosensor comprises glass substrates, wherein the two sides of each glass substrate are respectively provided with an ITO (indium tin oxide); parts of glass substrates at the same side as well as the ITOs of the parts of glass substrates are covered with graphene; the ITOs at the two sides of each glass substrate without graphene are respectively a source electrode and a drain electrode; a PET (polyethylene glycol terephthalate) gasket is covered on each ITO covered with the graphene and is covered with a PET substrate on which a gold film is sputtered; a sample cell is arranged in the middle of each glass substrate by insulating silica gel; the gold film is taken as a grid electrode. The contact resistance is reduced by means of covering the ITOs with graphene, the plane gold film electrode is taken as the grid electrode to exert a uniform electric field and increase the action area of electrolyte and graphene, and by the two aspects, the detection sensitivity is improved and the detection range is enlarged; by detection, the lower limit of adenosine triphosphate reaches 10pM.

Description

technical field [0001] The invention relates to the field of analytical chemistry, in particular to a graphene field effect tube biosensor, a manufacturing method and a detection method thereof. Background technique [0002] Graphene is an emerging functional material. Due to its excellent optical, electrical and easy to combine with biomolecules through π-π stacking, it has attracted attention in the field of biosensor design. Adsorption of biomolecules on the graphene surface can regulate its charge transport or channel doping of charges, causing changes in carrier concentration and carrier mobility. Based on this, graphene field-effect transistor (FET) biosensors modulated by applying gate voltage have been widely studied, such as pH sensor, DNA biosensor, protein biosensor, and cell biosensor. [0003] Usually, in the graphene field effect tube biosensor, the chemical vapor deposition method is used, and the SiO 2 Or plastic substrates transfer single-layer or multi-l...

Claims

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Application Information

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IPC IPC(8): G01N27/414
CPCH01L29/1606H01L29/66015G01N27/4148G01N27/4146
Inventor 岳伟伟许士才姜守振白成杰
Owner SHANDONG NORMAL UNIV
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