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Device based on liquid metal and used for repairing defective peripheral nerve function

A technology of liquid metal and peripheral nerves, applied in the field of medical devices, can solve the problems of abnormal conduction of excitatory signals of the body, muscle atrophy, long regeneration time, etc., avoid secondary neurosurgery, good flexibility and conductivity, and improve Quality of Life Effects

Active Publication Date: 2015-04-15
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, the regeneration after the repair of the defective nerve requires a long growth process, ranging from a few months to a few years, and the final regeneration result cannot be predicted in advance. It will be longer, and the repair effect will not be ideal
In the process of nerve regeneration, the body's excitatory signals cannot be normally transmitted, which greatly affects the quality of life of patients
For example, for some nerve defects that control the movement of limbs, if the regeneration process is long, the limbs cannot move for a long time, which may cause adverse consequences such as muscle atrophy

Method used

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  • Device based on liquid metal and used for repairing defective peripheral nerve function
  • Device based on liquid metal and used for repairing defective peripheral nerve function
  • Device based on liquid metal and used for repairing defective peripheral nerve function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Such as figure 1 with figure 2 As shown, a liquid metal-based device for functional repair of defective peripheral nerves includes a concentric sleeve structure composed of an outer tube 1 and an inner tube 2, and the inner tube 2 is arranged with biodegradable materials. The loose porous structure is used as a scaffold, and then filled with nerve growth-promoting substances 3, the middle part of the channel between the outer wall of the inner tube 2 and the inner wall of the outer tube 1 is injected with a liquid metal material 4, and conductive nanomaterials 5 are placed at both ends.

[0031] Wherein, the outer tube 1 and the inner tube 2 are selected from non-toxic, biocompatible and flexible biomaterials, such as chitosan, collagen, alginic acid and the like are used here. The concentric casing structure is made by precise micro-machining method, which is used as a catheter for repairing damaged nerves.

[0032] Secondly, using micro-molding processing technolog...

Embodiment 2

[0037] Such as Figure 4 with Figure 5 As shown, another form of a liquid metal-based device for functional repair of defective peripheral nerves includes a multi-channel catheter 6 with multiple axial channels, and the diameter of the inner channel of the multi-channel catheter 6 ranges from about 5 -50 μm, the pore size range of the outer channel is approximately 100-200 μm. Nerve-growth-stimulating substances 3 are filled in the inner channel, liquid metal material 4 is injected into the middle of the outer channel, and conductive nanomaterials 5 are placed in both ends.

[0038] Among them, the multi-channel catheter 6 is first made of chitosan to make a hollow nerve catheter, and then one or more of chitosan, collagen and gelatin is poured into the tube, and the tube is made of micro-machining technology. In the multi-channel structure, the channel in the tube is set as a structure with a larger outer diameter and a smaller inner diameter.

[0039]Secondly, using a mi...

Embodiment 3

[0043] Such as Figure 7 As shown, another form of a liquid metal-based device for functional repair of defective peripheral nerves includes a hollow sheet structure 7, one side of which is coated with a nerve growth-promoting substance 3, and liquid metal material is injected into the middle of the hollow part 4. Conductive nano-materials 5 are placed at both ends.

[0044] Among them, the hollow sheet-like structure 7 is made of one or more of collagen, chitosan, alginic acid, etc. to make a hydrogel-like substance, and then cut into a hollow sheet-like structure by using laser cutting technology, It is used to repair broken nerves that are not long in length, do not require bridges, and can be sutured directly. Wherein, the thickness of the sheet structure is 300-500 μm, and the thickness of the hollow part is 100-200 μm.

[0045] Then, one side of the hollow sheet-like structure 7 is coated with the nerve growth-promoting substance 3 . Using a micro-injection device, in...

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Abstract

A device based on a liquid metal and used for repairing a defective peripheral nerve function comprises a concentric sleeve structure formed by an outer pipe and an inner pie, wherein a nerve growth promotion substance is filled in the inner pipe, a liquid metal material is filled in a channel between the outer wall of the inner pipe and the inner wall of the outer pipe, and conductive nanometer materials are placed in two ends; or the device comprises a multichannel catheter which is provided with a plurality of axial channels, wherein the bore diameter of an inner side channel of the multichannel catheter is larger than that of the outer side channel, the nerve growth promotion substance is filled in the inner side channel, the liquid metal material is filled in the middle of the outer side channel, and the conductive nanometer materials are placed in two ends; or the device comprises a hollow sheet structure body, wherein one side of the structure body is coated with the nerve growth promotion substance, the liquid metal material is filled in the middle of a hollow part, the conductive nanometer materials are placed in two ends, and the liquid metal material is gallium, a gallium indium alloy or a gallium indium and tin alloy. The device is used for repairing the defective peripheral nerve function, can promote nerve growth, and maintains a signal transmission function of a never regeneration process.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and in particular relates to a liquid metal-based device for functional repair of defective peripheral nerves. Background technique [0002] The nervous system is one of the main functional regulation systems in the human body, and the nervous system is also the commander of the human body to respond to changes in the external environment. Therefore, once the nerves are damaged, especially when the damage occurs on the nerves that regulate the important life activities of the body, it will seriously affect people's quality of life, and may cause motor defects, paralysis, and even death. [0003] Nerve injury diseases, especially irreversible injuries, or irreparable nerve injuries due to untimely detection of lesions are very common. Many nerve injuries caused by pathology, such as encephalitis, spinal cord tumor, late stage of spinal cord inflammation, late stage of demyelinating diseas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/02A61B17/00A61L27/04A61L27/08A61L27/02A61L27/24A61L27/20A61L31/02A61L31/04
Inventor 张洁金超刘静
Owner TSINGHUA UNIV
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