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Pharmaceutical composition for treating gynecologic diseases and preparation method thereof

A technology for gynecological diseases and compositions, which is applied in the field of pharmaceutical compositions of marine biological materials and its preparation, can solve problems affecting human health, inconsistent standards, side effects, etc., and achieve the promotion of gynecological physiological acid-base balance and high antibacterial efficiency , good tissue compatibility

Active Publication Date: 2013-12-04
GUANGZHOU TENGJIAN MARINE LIFE SCI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Most of the gynecological products currently sold in the domestic and foreign markets are various lotions, suppositories, etc., emphasizing the use of antibiotics; there are also some gel products, the main source of raw materials is a mixture of heavy metals (nano-silver) and other ingredients , low antibacterial, easy to make, some of its ingredients are more complicated, nano-level standards are not uniform, and there are side effects after the human body filter organs, such as kidney residues, long-term use affects human health; although there are some gynecological products that use marine biological materials on the market preparations, but the marine biological materials used are common medical chitosan

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] This embodiment provides a preparation example of the pharmaceutical composition of the present invention and a technical requirement compliance test.

[0028] 1. Raw material selection

[0029] Chitosan for medical use: Chitosan (Chitosan, CS) is a product of chitin deacetylation (molecular weight ≥5000, deacetylation degree ≥90%, particle size 100 mesh, moisture ≤6%, ash content ≤0.6%, the total number of heavy metals and bacteria must not exceed the national standard), is a natural amino polysaccharide derived from marine organisms, for many It is a medical polymer polysaccharide substance with good physical and chemical properties, biocompatibility, biodegradability and biological activity, which can inhibit the growth of bacteria and show antibiotic-like effects. It is easily soluble in water and has good properties. Stable, with good moisture absorption, moisturizing, conditioning, antibacterial and other functions. As a biomedical material, it has been graduall...

Embodiment 2

[0049] This example is another preparation experiment using the raw materials described in Example 1 and an example of technical requirements compliance testing.

[0050] One, the preparation of pharmaceutical composition:

[0051] (1) Weigh 20g of medical chitosan, 25g of Chitosan, 15g of Meretrix meretrix and 40g of Glossitis meretrix, mix and sterilize with gamma ray irradiation;

[0052] (2) The above-mentioned sterilized mixture is sheared and emulsified at 8000 rpm, heated to 60-98°C and stirred evenly to obtain an emulsified product;

[0053] (3) Adding an acid-base adjusting agent to the emulsion, adjusting the pH value to 3.8-4.5, and degassing to obtain a pharmaceutical composition;

[0054] (4) Pour the pharmaceutical composition into a 3ml high-density polyethylene material (HDPE) push-type medical drug delivery tube.

[0055] Two, the technology standard inspection result of pharmaceutical composition of the present invention:

[0056] The following are the tes...

Embodiment 3

[0066] This example is another preparation experiment using the raw materials described in Example 1 and an example of technical requirements compliance testing.

[0067] One, the preparation of pharmaceutical composition:

[0068] (1) Weigh 25g of medical chitosan, 45g of Qiongzhi, 15g of Meretrix meretrix and 15g of Glossitis meretrix, mix and sterilize with gamma ray irradiation;

[0069] (2) The above-mentioned sterilized mixture is sheared and emulsified at 8000 rpm, heated to 60-98°C and stirred evenly to obtain an emulsified product;

[0070] (3) Adding an acid-base adjusting agent to the emulsion, adjusting the pH value to 3.8-4.5, and degassing to obtain a pharmaceutical composition;

[0071] (4) Pour the pharmaceutical composition into a 3ml high-density polyethylene material (HDPE) push-type medical drug delivery tube.

[0072] Two, the technology standard inspection result of pharmaceutical composition of the present invention:

[0073] The following are the tes...

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Abstract

The invention aims to provide a pure natural oceanic biological pharmaceutical composition which adopts brand-new oceanic biological active matters, is made by scientific components, and is high in antibacterial efficiency. The pharmaceutical composition mainly comprises medical chitosan, Eucheuma gelatinae, clam, and caloglossa. The invention further provides a preparation method of the pharmaceutical composition, the medical production formulation of the pharmaceutical composition, and application of the pharmaceutical composition in gynecologic drugs. The pharmaceutical composition extracted from natural oceanic animals and plants is nontoxic, stimulation-free, immune-antigenicity-free and good in histocompatibility, and is natural high-molecular compound which can be degraded and absorbed in bodies. The external preparation made by the pharmaceutical composition is convenient to use, high in antibacterial efficiency, capable of promoting epithelial cell growing and gynecologic physiological acid-base balance, and applicable to various gynecologic disease treating processes such as wound repair, bleeding stopping, bacteria inhibition and inflammation diminishing, packing after operation, and interventional therapy.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a pharmaceutical composition of marine biological materials for treating gynecological diseases and a preparation method thereof. Background technique [0002] With the development of social economy and culture and the enhancement of women's self-care awareness, in recent years, the market demand for gynecological inflammation medicines has been huge, and the sales amount of gynecological inflammation medicines has increased rapidly. The market is showing a prosperous scene with frequent hot spots. According to the latest statistics from the Research Center of an authoritative market organization, the market size of gynecological inflammation drugs in 2010 was about 10.28 billion yuan, an increase of 16.84% over the previous year; from the perspective of the growth trend of the entire market, the growth of the gynecological inflammation drug market is stable. Authoritative mar...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P15/00A61P31/04A61P31/10A61K35/56A61K35/618
Inventor 阎玲
Owner GUANGZHOU TENGJIAN MARINE LIFE SCI TECH