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Bacteriostatic skin ointment and preparation method

An ointment and skin technology, applied in skin diseases, ointment delivery, antibacterial drugs, etc., can solve the problems of high cost, large side effects, complicated production, etc., and achieve the effect of low cost, small side effects, and simple preparation process

Active Publication Date: 2015-02-04
欧世文
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the antibacterial agents reported now are combined effects, that is, two or more main drugs are used in combination, which is relatively complicated to make, high in cost and has large side effects. Not many, even less reported for ointments

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation of Bornyl Fenyl Alcohol, a Saponification Product of Bornyl Oxalate

[0025] Take 362 g of bornyl oxalate and put it in a beaker, gradually add 400 mL of 20% NaOH solution under the condition of stirring. Then gradually add dilute hydrochloric acid (concentrated hydrochloric acid: water = 1:5) to neutralize excess alkali to neutrality, and then wash with water to remove impurities until the pH value is 6-7.

[0026] The preparation of skin ointment, component and mass ratio are:

[0027] Cetostearyl Alcohol 19.0

[0028] Vaseline 5.0

[0029] Liquid Paraffin 5.0

[0030] Borneofenitol 20.0

[0031] Glycerin 6.5

[0032] Sodium Lauryl Sulfate 1.8

[0033] Ethylparaben 0.1

[0034] Add distilled water to 100.0.

[0035] Take cetostearyl alcohol, petrolatum, liquid paraffin, borneol fennel alcohol of the oil phase, put them in a container, heat and melt in a water bath at 60-80 °C, and keep the temperature at a constant temperature for 10 m...

Embodiment 2

[0037] The preparation of bornyl fennel alcohol, a saponification product of bornyl oxalate, is the same as in Example 1.

[0038] The preparation of skin ointment, component and mass ratio are:

[0039] Cetostearyl Alcohol 24.0

[0040] Vaseline 7.0

[0041] Liquid Paraffin 7.0

[0042] Borneofenitol 23.0

[0043] Glycerin 8.5

[0044] Sodium Lauryl Sulfate 2.1

[0045] Ethylparaben 0.12

[0046] Add distilled water to 100.

[0047] Take cetostearyl alcohol, vaseline, liquid paraffin, borneol fennel alcohol in the oil phase, put them in a container, heat and melt in a water bath, keep at 80 °C, and keep the constant temperature for 5 min; take sodium lauryl sulfate, glycerin, Put the distilled water in another container and heat it to about 80 ℃, keep the constant temperature for 5 minutes, add ethylparaben, after dissolving, slowly add the water phase liquid into the oil phase liquid, and keep stirring until it is finalized.

Embodiment 3

[0049] The preparation of bornyl fennel alcohol, a saponification product of bornyl oxalate, is the same as in Example 1.

[0050] The preparation of skin ointment, component and mass ratio are:

[0051] Cetostearyl Alcohol 14.0

[0052] Vaseline 3.0

[0053] Liquid Paraffin 3.0

[0054] Borneofenitol 17.0

[0055] Glycerin 4.50

[0056] Sodium Lauryl Sulfate 1.5

[0057] Ethylparaben 0.08

[0058] Add distilled water to 100.

[0059] Take cetostearyl alcohol, petrolatum, liquid paraffin, and borneol fennel alcohol in the oil phase, put them in a container, heat and melt them in a water bath, and keep at 60 °C for 10 minutes at a constant temperature; take sodium lauryl sulfate, glycerin, and Put the distilled water in another container and heat it to about 60 ℃, keep the constant temperature for 10 minutes, add ethylparaben, after dissolving, slowly add the water phase liquid into the oil phase liquid, and keep stirring until the shape is finalized.

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PUM

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Abstract

The invention relates to a bacteriostatic skin ointment which comprises the following components in parts by mass: 14-24 parts of cetearyl alcohol, 3-7 parts of vaseline, 3-7 parts of liquid paraffin, 17-23 parts of borneol fenchol, 4.5-8.5 parts of glycerol, 1.5-2.1 parts of lauryl sodium sulfate, 0.08-0.12 parts of ethylparaben, and 100 parts of water. A preparation method comprises the steps of placing cetearyl alcohol, the vaseline, the liquid paraffin and borneol fenchol in a container, conducting a water bath at 74 DEG C, heating, melting, keeping the constant temperature for 0.5h, placing sodium lauryl sulfate, glycerol and the distilled water in another container, heating to 73 DEG C, mixing an oil phase, heating in the water bath to 60-80 DEG C, mixing, heating to 60-80 DEG C, adding ethylparaben, dissolving, adding an aqueous phase solution to an oil phase solution slowly, and continuously stirring till the skin ointment is formed. The skin ointment is hormone-free and good in itch relieving effect, and a preparation technology is simple, easy to popularize and low in cost.

Description

technical field [0001] The invention relates to a skin antibacterial agent-skin ointment, which uses bornyl fennel alcohol, a saponification product of bornyl oxalate, as the main agent. The invention also relates to a preparation method of the skin ointment. Background technique [0002] There have been a large number of literature and patent reports on bacteriostatic agents for skin, and existing drugs on the market, such as hydroxychloroquine, dapsone, and thalidomide, can be used as new options for skin bacteriostatic agents, and have also been recognized. The attention and research of many scientific researchers. The invention patent application with the application number CN200510106633.1 provides a medical stone cream for treating skin diseases and its preparation method; the invention patent with the application number CN200810072492. Comfrey, pearl powder, honeycomb, medicated oil and matrix are the main antibacterial agents. Examples of combined drug use skin an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/045A61K9/06A61P31/04A61P17/04
Inventor 欧世文
Owner 欧世文