Injectable liquid metal bone cement, preparation method of injectable liquid metal bone cement and special injection device for injectable liquid metal bone cement

A technology of liquid metal and bone cement, applied in X-ray contrast agent preparation, medical science, joint implants, etc., can solve the problems of endangering human health and complicated operation, and achieve short curing time, simple operation and fast curing speed Effect

Active Publication Date: 2013-12-11
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if barium sulfate enters the blood, it will seriously endanger human health.
Moreover, these two bone cement materials need to be solidified by mixing the solid phase and the liquid phase, and the operation is relatively complicated.

Method used

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  • Injectable liquid metal bone cement, preparation method of injectable liquid metal bone cement and special injection device for injectable liquid metal bone cement
  • Injectable liquid metal bone cement, preparation method of injectable liquid metal bone cement and special injection device for injectable liquid metal bone cement
  • Injectable liquid metal bone cement, preparation method of injectable liquid metal bone cement and special injection device for injectable liquid metal bone cement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] First, liquid metal bone cement material 1 is prepared, which uses a bismuth (Bi)-based alloy:

[0039] Metal bismuth (Bi), metal indium (In), metal tin (Sn) and metal zinc (Zn) were mixed in an empty beaker according to the mass fractions of 35%, 48.7%, 15.9% and 0.4%. Put the beaker into a vacuum oven and heat continuously for 20 hours at a temperature of 360°C. At this time, several metals are mixed together to form a molten metal state. In order to ensure the uniformity of the alloy composition, put it on a magnetic stirring heater, heat and melt it at 160°C, and fully stir it for 4 hours. The obtained low melting point alloy had a melting point of 59.1°C. The prepared low-melting-point alloy bone cement can be stored at room temperature for a long time after being sealed.

[0040] After the preparation of the liquid metal bone cement material 1 is completed, it can be filled into the target area and solidified to form a support body 3, which is used for artifici...

Embodiment 2

[0046] The difference from Example 1 is that the liquid metal bone cement material in this example is a gallium (Ga)-based alloy, and its composition is: the mass percentage of metal gallium (Ga) is 40%, metal indium (In) The mass percentage content of tin is 30%, and the mass percentage content of metal tin (Sn) is 30%. Other materials and steps are the same as in Example 1.

Embodiment 3

[0048] Different from Example 1, this example uses a special injection device for injection, such as figure 2 As shown, the special injection device adds an insulation layer or heating device 9 to the outside of the syringe 2, and uses external equipment to control the temperature of the insulation layer or heating device 9 through the connection line 10, so that the temperature is controllable and measurable.

[0049] Because the liquid metal bone cement material 1 has a low melting point and a fast solidification speed, the special injection device in this embodiment can keep it in a liquid state for a long time in the injection device, preventing it from solidifying in the syringe. Before the liquid metal bone cement material 1 is sucked into the syringe 2, an external control device is used to heat the insulation layer or the heating device 9 outside the syringe 2. Through the built-in temperature sensor of the insulation layer or the heating device 9, the temperature val...

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Abstract

The invention relates to injectable liquid metal bone cement which uses liquid metal as a main component. The liquid metal has the melting point of 45 to 100 DEG C and is bismuth-base alloy or gallium-base alloy. The invention further provides a preparation method of the injectable liquid metal bone cement and a special tool for implementing the preparation method. The bone cement disclosed by the invention is injectable, has a high curing speed and a low solidification temperature, adopts a simple preparation process, has a stable structure in the in-vitro and in-vivo environments, can be recycled and has an X-ray self-developing function.

Description

technical field [0001] The invention relates to the technical field of bone defect repair, in particular to an injectable liquid metal bone cement, a preparation method thereof and a special injection device. Background technique [0002] For a long time, osteoporosis, bone tumors, bone defects and other bone diseases and joint diseases have seriously endangered human health as major diseases. Especially in the elderly population, the prevalence of such diseases is increasing year by year. As a repair material widely used in clinical orthopedic diseases, bone cement can effectively improve the physical condition of patients with such diseases. Its main applications include artificial joint replacement, bone defect repair and replacement, etc. The bone cements commonly used clinically today mainly include polymethyl methacrylate and calcium phosphate bone cement. [0003] Among them, polymethyl methacrylate (PMMA) bone cement is often used for the fixation of orthopedic im...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/02A61L27/54A61L27/50A61L31/02A61L31/16A61L31/14A61K49/04A61B17/88A61F2/46
Inventor 衣丽婷金超刘静
Owner TSINGHUA UNIV
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