Preparation method of carbon nanotube reinforced composite nerve guide

A carbon nanotube and composite material technology, applied in the medical field, can solve the problems of carbon nanotubes that have not been reported, and achieve the effects of easy storage and maintenance, reasonable structure design, and simple preparation method.

Active Publication Date: 2016-07-06
SHANDONG PROVINCIAL HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of carbon nanotubes in peripheral nerve repair has not been reported either in vivo or in vitro.

Method used

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  • Preparation method of carbon nanotube reinforced composite nerve guide
  • Preparation method of carbon nanotube reinforced composite nerve guide
  • Preparation method of carbon nanotube reinforced composite nerve guide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Step 1: Functional modification of carbon nanotubes

[0051] The following methods are used to modify different functional groups on the surface of carbon nanotubes so that the surface of carbon nanotubes carry different charges and functional group molecules to improve the dispersibility and biocompatibility of carbon nanotubes. The specific methods are as follows:

[0052] (1) Mix the carbon nanotubes with 2.0M sodium hydroxide ultrasonically and reflux for 12 hours, and then centrifuge, filter, clean and dry the carbon nanotubes to obtain high-purity carbon nanotubes with hydroxyl groups on the surface;

[0053] (2) The mixed acid adopts the ratio of sulfuric acid:nitric acid = 3:1, reflux the carbon nanotubes in the mixed acid at 80°C for 30 minutes, repeatedly wash with deionized water to avoid introducing other impurities, and then centrifuge, filter and clean the carbon nanotubes And drying to obtain high-purity carbon nanotubes with carboxyl groups on the surface;

[00...

Embodiment 2

[0066] Step 1: Functional modification of carbon nanotubes

[0067] The following methods are used to modify different functional groups on the surface of carbon nanotubes, so that the surface of carbon nanotubes carry different charges and functional group molecules to improve the dispersibility and biocompatibility of carbon nanotubes. The specific methods are as follows:

[0068] (1) Mix the carbon nanotubes with 2.0M sodium hydroxide ultrasonically and reflux for 12 hours, and then centrifuge, filter, clean and dry the carbon nanotubes to obtain high-purity carbon nanotubes with hydroxyl groups on the surface;

[0069] (2) The mixed acid adopts the ratio of sulfuric acid:nitric acid = 3:1, reflux the carbon nanotubes in the mixed acid at 80°C for 30 minutes, repeatedly wash with deionized water to avoid introducing other impurities, and then centrifuge, filter and clean the carbon nanotubes And drying to obtain high-purity carbon nanotubes with carboxyl groups on the surface;

[0...

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Abstract

The invention provides a making method of a carbon nanotube reinforced composite material nerve conduit, and belongs to the medical technology field. The making method concretely comprises the following steps: modifying the surface of a carbon nanotube with different functional groups to make the surface of the carbon nanotube carry different charges and functional group molecules in order to improve the dispersibility and biocompatibility of the carbon nanotube; and adopting an ultrasonic dispersion process to fully mix the functionally modified carbon nanotube with an acid-soluble chitosan solution in order to make the carbon nanotube uniformly dispersed in the chitosan solution, mixing with collagen after uniform dispersion, and continuously carrying out ultrasonic dispersion until uniform dispersion. The functionally modified carbon nanotube is adopted by the making method of the carbon nanotube reinforced composite material nerve conduit to improve the physical, chemical and biologic performances of the chitosan / collagen composite material nerve conduit as an enhance component, and the functionally modified carbon nanotube reinforced composite material nerve conduit is used for restoring peripheral nerve defects.

Description

Technical field [0001] The invention relates to the field of medical technology, in particular to a method for preparing a carbon nanotube reinforced composite material nerve catheter. Background technique [0002] Generally, the application of autologous or allogeneic nerve transplantation to repair peripheral nerve defects has difficult problems such as scarce supply and immune rejection. Therefore, the preparation of substitutes for peripheral nerves has become a research hotspot in the field of peripheral neurosurgery in recent years. [0003] In recent years, the application of nanotechnology in the field of tissue reconstruction has been very active. There are many related studies on the application of nanomaterials to bone repair, but there are few reports on the application of nanomaterials to the peripheral nervous system. It is reported that carbon nanotubes can not only reduce the production of scar tissue, but also stimulate the neurons of the central nervous system t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/44
Inventor 赵文蒋丽霞王英张志愿张东升张世周郑家伟
Owner SHANDONG PROVINCIAL HOSPITAL
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