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Pharmaceutical composition consisting of ceftriaxone sodium for injection and 1% lidocaine hydrochloride injection

Inactive Publication Date: 2013-12-18
HAINAN YONGTIAN PHARMA INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the prior art, there is no combined package of ceftriaxone sodium for injection and 1% lidocaine hydrochloride injection on the market and in medical institutions; in clinical use, it is necessary to purchase the joint application separately

Method used

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  • Pharmaceutical composition consisting of ceftriaxone sodium for injection and 1% lidocaine hydrochloride injection
  • Pharmaceutical composition consisting of ceftriaxone sodium for injection and 1% lidocaine hydrochloride injection
  • Pharmaceutical composition consisting of ceftriaxone sodium for injection and 1% lidocaine hydrochloride injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The preparation of embodiment 1 ceftriaxone sodium for injection

[0031] prescription:

[0032]

[0033] making process:

[0034] (1) 250g of ceftriaxone sodium sterile powder (in C 18 h 18 N 8 o 7 S 3 meter) into the subpackaging room (the ambient temperature of the subpackaging post is 18°C-26°C, and the relative humidity is below 65%), debug the subpackaging machine, adjust the number of steps to adjust the loading volume, so that the loading volume reaches the specified range, and then distribute Put it in a low borosilicate glass control injection bottle, press the stopper completely, and crimp the cap.

[0035] (2) 500g of ceftriaxone sodium sterile powder (in C 18 h 18 N 8 o 7 S 3 meter) into the subpackaging room (the ambient temperature of the subpackaging post is 18°C-26°C, and the relative humidity is below 65%), debug the subpackaging machine, adjust the number of steps to adjust the loading volume, so that the loading volume reaches the speci...

Embodiment 2

[0038] Example 2 Preparation of Lidocaine Hydrochloride Injection

[0039] prescription:

[0040]

[0041] making process:

[0042] (1) Add a total of 1600ml of water for injection into the liquid mixing tank;

[0043] (2) Add 20g of lidocaine hydrochloride (in C 14 h 22 N 20 HCl meter), stir to dissolve completely;

[0044] (3) Weigh 1.0g of activated carbon for injection in the carbon mixing cabinet, add 50ml of water for injection to wet the activated carbon for injection, and set aside;

[0045] (4) Add the wetted activated carbon for injection and stir for 30 minutes;

[0046] (5) The solution is decarburized by coarse filtration and filtered through a 0.45 μm cartridge filter;

[0047] (6) Add water for injection to 2000ml;

[0048] (7) Adjust the pH value of the liquid to 3.5-5.5.

[0049] (8) Use a 0.22 μm microporous membrane to sterilize and filter until the visible foreign matter is qualified, fill it with 2ml / bottle or 5ml / bottle, seal it, and steriliz...

Embodiment 3

[0050] The preparation of embodiment 3 combination packaging medicines

[0051] Combination 1: Ceftriaxone Sodium for Injection 0.25g and Lidocaine Hydrochloride Injection 2ml.

[0052] Combination 2: 0.5 g of ceftriaxone sodium for injection and 2 ml of lidocaine hydrochloride injection.

[0053] Combination 3: 1.0 g of ceftriaxone sodium for injection and 2 ml of lidocaine hydrochloride injection.

[0054] Combination 4: 2.0 g of ceftriaxone sodium for injection and 2 ml of lidocaine hydrochloride injection.

[0055] Combination 5: 0.25 g of ceftriaxone sodium for injection and 5 ml of lidocaine hydrochloride injection.

[0056] Combination 6: 0.5 g of ceftriaxone sodium for injection and 5 ml of lidocaine hydrochloride injection.

[0057] Combination 7: 1.0 g of ceftriaxone sodium for injection and 5 ml of lidocaine hydrochloride injection.

[0058] Combination 8: 2.0 g of ceftriaxone sodium for injection and 5 ml of lidocaine hydrochloride injection.

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PUM

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Abstract

The invention relates to a pharmaceutical composition consisting of ceftriaxone sodium for injection and 1% lidocaine hydrochloride injection, in particular to a combined application package consisting of ceftriaxone sodium for injection and 1% lidocaine hydrochloride injection. When the pharmaceutical composition is in use, the 1% lidocaine hydrochloride injection is added into the ceftriaxone sodium for injection to prepare a solution, wherein every 1ml of the solution contains 250mg of ceftriaxone sodium. Moreover, the pharmaceutical composition is used injected intramuscularly. The pharmaceutical composition not only has a broad-spectrum antibacterial effect but also can obviously reduce local pain caused by injection of the ceftriaxone sodium.

Description

technical field [0001] The invention relates to a pharmaceutical composition of ceftriaxone sodium for injection and lidocaine hydrochloride injection, in particular to a combined application package of a sterilized injection prepared from ceftriaxone sodium for injection and lidocaine hydrochloride , belonging to the field of medical technology. Background technique [0002] Ceftriaxone sodium is a third-generation cephalosporin antibiotic. Strong activity against Enterobacteriaceae bacteria. The MIC90 for Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Citrobacter freundii, indole-positive Proteus, Pruvidenella and Serratia is between 0.12 and 0.25mg / Between L. Enterobacter cloacae, Acinetobacter and Pseudomonas aeruginosa have poor sensitivity to this product. It has strong antibacterial effect on Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis, and also has good effect on hemolytic streptococcus and pneumococcus. The MIC fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K9/08A61K31/546A61K31/167A61P29/02A61P31/04A61P23/02
Inventor 王明
Owner HAINAN YONGTIAN PHARMA INST