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Cleansing solution for curing gynecological disease and preparation method thereof

A technology for lotion and women's use, applied in the field of lotion for treating gynecological diseases, can solve the problems of short retention time of active ingredients, insufficient killing of pathogenic bacteria, insufficient antibacterial effect, etc., and achieve the effect of good antibacterial synergy.

Inactive Publication Date: 2015-05-13
北京中润启源生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] As a topical antibacterial agent and wound care agent for vaginal use, although chitosan has a good effect on wound repair (for example, in wound repair and care), it is obviously insufficient in terms of antibacterial properties, especially in killing pathogenic bacteria , especially in the form of lotion, when washing the vagina, the active ingredients in the lotion have a short retention time in the vagina and a low effective concentration. Chitosan alone is a component that is suitable for the treatment of severe and intractable gynecological diseases. , there is insufficient antibacterial effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1. Chitosan chlorhexidine lotion for women and its preparation method

[0070] Formula: Chitosan 0.25g (viscosity average molecular weight is 60,000, deacetylation degree ≥90%)

[0071] Chlorhexidine acetate 0.2g

[0072] Glycerin 8g

[0073] 37% hydrochloric acid and glacial acetic acid mixture (V:V=5:1)

[0074] Purified water is added to 100g.

[0075] Preparation method: It includes mixing chitosan with purified water to form a suspension in an environment with a cleanliness of 100,000, adding a mixture of hydrochloric acid and glacial acetic acid to make the reactants form a washing liquid, and making the pH value of the washing liquid at 4~5, get the chitosan solution, dissolve chlorhexidine acetate in glycerin, add the chitosan lotion, stir evenly, degas, fill in a plastic bottle or vaginal douche bottle and seal, and further use 10~ 11KGy dose of cobalt-60 radiation sterilization treatment, to obtain the chitosan chlorhexidine sterile loti...

Embodiment 2

[0076] Example 2. Chitosan chlorhexidine lotion with the following formula

[0077] Formula: Chitosan 0.3%~0.7%,

[0078] Chlorhexidine 0.1%~0.5%,

[0079] Glycerin 5%~10%,

[0080] Acidulant appropriate amount,

[0081] Purified water is added to 100g;

[0082] Wherein, chlorhexidine includes chlorhexidine acetate, chlorhexidine gluconate, chlorhexidine hydrochloride or chlorhexidine citrate, the acidifying agent is lactic acid, acetic acid or a mixture of hydrochloric acid and acetic acid, and the lotion is The viscosity change rate after cobalt-60 irradiation treatment is less than + 10%, the pH of the lotion is 3.8~5.8. The preparation method of the above-mentioned chitosan chlorhexidine washing lotion is as follows:

[0083] It includes mixing chitosan with purified water in a clean environment of 100,000 grades to form a suspension, adding acidulant to adjust the pH to 3.8-5.8 to obtain a chitosan solution, and dissolving chlorhexidine in glycerin , Add to the c...

Embodiment 3

[0084] Example 3. Chitosan chlorhexidine lotion and preparation method thereof

[0085] Formula: Chitosan 0.4g (Viscosity average molecular weight is 50,000, deacetylation degree ≥95%)

[0086] Chlorhexidine acetate 0.3g

[0087] Menthol 0.01g

[0088] Glycerin 8g

[0089] 37% hydrochloric acid and glacial acetic acid mixture (V:V=5:1)

[0090] Purified water is added to 100g.

[0091] Preparation method: It includes mixing chitosan with purified water to form a suspension in an environment with a cleanliness of 100,000, adding a mixture of hydrochloric acid and glacial acetic acid to make the reactants form a washing liquid, and making the pH value of the washing liquid at 4~5, get the chitosan solution, dissolve chlorhexidine acetate and menthol in glycerin, add the chitosan lotion, stir evenly, degas, fill it in a high-density polyethylene vaginal washing bottle and seal it. Furthermore, it is sterilized by irradiation with cobalt-60 radiation at a dose ...

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Abstract

The invention relates to a sterile lotion for women, which is composed of chitosan with specific molecular weight and deacetylation degree, chlorhexidine, glycerin, acidulant and purified water. Chitosan is mixed with purified water to form a suspension, and an acidulant is added to adjust the pH to 3.8-5.8 to obtain a chitosan gel. Separately, chlorhexidine is dissolved in glycerin, added to the chitosan gel, stirred evenly, and removed. Gas, can be filled and sealed, and sterilized, wherein the acidifying agent is a mixture of lactic acid, acetic acid or hydrochloric acid-acetic acid, and the sterilization adopts cobalt-60 radiation treatment or high-temperature moist heat sterilization, and the present invention also relates to its preparation method , and the application in the preparation of medicines for treating women's candida vaginitis, bacterial vaginitis, trichomonal vaginitis or cervicitis, or for daily hygiene care of women's vagina.

Description

technical field [0001] The present invention relates to the field of pharmaceutical products. Specifically, the present invention relates to a lotion for treating gynecological diseases, which is used for the treatment of women's candida vaginitis, bacterial vaginitis, mixed vaginitis, and cervicitis. The curative effect, safety, natural, good biocompatibility and other advantages, the invention also relates to its preparation method and medical application. Background technique [0002] Ideal gynecological topical pharmaceutical products should have good antibacterial and anti-inflammatory properties, safety, biocompatibility, and ease of use. They should also be stable, easy to store, and easy to use. [0003] Chitosan (Chitosan), chemically named poly(1,4)-2-amino-2-deoxy-β-D-glucose, is a natural biopolymer obtained after partial or complete deacetylation of chitin. It is the only macromolecular alkaline polysaccharide existing in nature, also known as soluble chitin, c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/722A61P31/04A61P15/02A61P15/00A61P33/02A61K31/155
Inventor 张耿元白东跃庄灵习王保红
Owner 北京中润启源生物科技有限公司
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