A preparation method of bionic artificial bone with multi-level [micro/nano] pore structure

Abstract

The invention relates to a preparation method of a bionic artificial bone with a multistage [micrometer / nanometer] pore structure. The method is characterized by the following steps of: realizing 150-800 mum gradient through pores by selective laser sintering (the diameter of the light spot is micrometer scale); mixing and performing oxygenolysis on a small amount of high polymer microballoons in the sintering process to form 10-100 mum random spherical pores; finally obtaining the bionic artificial bone which has an three-dimensional hierarchical pore structure similar to that of a natural bone by a method of obtaining irregular pores in tens of nanometer surfaces by a corrosion process. In the invention, according to the requirement of an implanting position, the distribution, connectivity and the like of the gradient through pore can be accurately controlled by adjusting sintering process parameters; the shape, size and the like of the spherical pores can be controlled by precisely controlling the furnace temperature curve and high polymer particle properties; the size, quantity and the like of the nanometer pores can be controlled by controlling the corrosion liquid concentration and corrosion time. The preparation method disclosed by the invention has an important significance in creating a microenvironment beneficial to cell adhesion, proliferation and function exertion, improving forming of new bones, and increasing healing of bones.

Description

technical field [0001] The invention belongs to the field of bionic manufacturing of bone tissue engineering, and in particular provides a method of using selective laser sintering to realize gradient through holes of 150-800 μm and using a small amount of mixed polymer micro The spheres are oxidized and decomposed during the sintering process to form random spherical pores of 10-100 μm, and the surface irregular pores of tens of nanometers are obtained by corrosion process, and finally a bionic artificial bone with a three-dimensional hierarchical porous structure similar to autologous bone is obtained. technical background [0002] The loss or dysfunction of human tissue is a major problem that threatens human health, and it is also the most important cause of human illness and death. Especially in recent years, with the aging of the population and the development of industry, transportation, sports and other undertakings, people have increasingly urgent requirements for t...

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Problems solved by technology

[0007] Aiming at the lack of control of the pore structure and the problem of a single structure in the existing method, the present invention proposes a method of using selective laser sintering to realize gradient through holes of 150-800 μm, using a small amount of mixed polymer microspheres and oxidizing them during the sintering process. Decompose and form random spherical pores of 10-100μm, and use corrosion technology to obtain tens of nanometer surface irregular pores, and finally obtain a bionic artificial bone with a three-dimensional multi-level porous structure similar to natural bone, and the diameter of the laser spot is on the scale of microns

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