Constraint bed adsorption separation technology and method

Abstract

The invention discloses a constraint bed adsorption separation technology. The constraint bed adsorption separation technology is mainly characterized in that an adsorbent is constrained on a fixed framework by utilizing an external force, gaps among a column body, the fixed framework, the adsorbent or a 'constraint assembly' constrained by an 'aggregate' allow solid particles to pass through, and as long as the flow velocity of fluid does not exceed a 'constraint force', the adsorbent can keep an 'initial constraint state' and is regularly arranged in a column of a constraint bed respectively according to three modes, namely hard constraint, soft constraint and aggregate constraint. The constraint bed adsorption separation technology can be used for directly extracting target ingredients from particle materials just like expanded bed adsorption to obtain a separation effect similar to that of a fixed bed, and also avoids the special conditions such as the adsorbent with certain density and particle size distribution, a fluid distributor system and specific flow velocity of the fluid necessary for an expanded bed; an expansion process is very convenient, low in cost and convenient to operate, and the constraint bed adsorption separation technology can be used for a material separation process, and especially can be used for a reaction process.

Description

Technical field [0001] The present invention involves a new type of separation technology, and specifically involves a constraint bed adsorption separation technology and method. Background technique [0002] Expanded Bed Adsorption (EBA) technology is a new type of separation and purification technology developed in the 1990s. It can capture target products directly from fermentation liquid or cells.Among one operation unit, the number of operating units was reduced, the operation time was shortened, and the production cost was saved. It was called the first new unit operation that appeared in recent decades.The expansion bed is also called stabilized Fluidized BED. The fillers in the bed are in a critical and doubling state.The number of stable grading behaviors is much higher than the ordinary fluidized bed, which is close to the fixed bed. [0003] However, to achieve a stable expansion bed state, three special conditions must be met at the same time.First, the solid fillers ...

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Problems solved by technology

One is that the solid filler in the expanded bed should have a relatively large density and a certain particle size distribution, so that when the bed expands, the large and heavy particles are at the bottom of the bed, and the small and light particles are at the top of the bed, forming a stable The classification behavior of this kind of expanded bed adsorbent is mostly monopolized by large foreign companies, and the price is expensive; second, the expanded bed device must be conducive to the formation of plug flow, especially at the fluid inlet and outlet of the device. There is an obvious jet area, such as the fluid distributor system launched by Denmark’s UpFront company named FastLine; third, a special operation method must be adopted, and the fluid flow rate should be controlled between the minimum fluidization velocity and the terminal velocity, especially for adsorbent adsorption. The properties of the corresponding substances will change, and it is necessary to adjust the flow rate, otherwise the state of the expanded bed cannot be maintained, and even the collapse of the expanded bed may occur

[0004] Among them, the design of fluid distributor and adsorbent is the most critical. In recent years, scholars from various countries have conducted a lot of research on this. Although some scholars have reported the application examples of pilot scale and production scale, most of the development of EBA process still only stays in the laboratory scale

The main reason is the above requirements on the expanded bed device, adsorbent and operation mode, especially the bridging effect caused by cell debris, nucleic acid anion substances, etc. Adjusting the flow rate and other operating conditions will also cause the collapse of the expanded bed, and the state of the expanded bed cannot be maintained. The industrialization of EBA technology has encountered a "bottleneck", which greatly limits the wide application of EBA technology in the field of bioengineering

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