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Meclofenoxate hydrochloride dry suspension and preparation method thereof

A technology of meclofen axetil hydrochloride and dry suspension is applied in the directions of antidote, pharmaceutical formulations, and medical preparations containing active ingredients, which can solve the problems of lack of meclofen axetil hydrochloride preparations for elderly and children, and achieve The preparation process is simple and easy to operate, the use is convenient, and the manufacturing cost is low.

Inactive Publication Date: 2014-01-01
天津市聚星康华医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] One of the purposes of the present invention is to provide a dry suspension of meclofenoxate hydrochloride with good taste and simple preparation process, so as to solve the problem of lack of meclofenoxate hydrochloride preparations suitable for elderly and children patients.

Method used

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  • Meclofenoxate hydrochloride dry suspension and preparation method thereof
  • Meclofenoxate hydrochloride dry suspension and preparation method thereof
  • Meclofenoxate hydrochloride dry suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Each bag contains meclofenoxate hydrochloride 100mg, and its prescription is:

[0021]

[0022] The preparation process is as follows: weigh meclofenoxate hydrochloride, xanthan gum, mannitol, sucralose, and pregelatinized starch, respectively pass through a 100-mesh sieve, and mix uniformly to obtain a dry suspension.

[0023] Evaluation: Weigh 1g of meclofenoxate hydrochloride dry suspension, add 20ml of hot water to stir and disperse, observe its suspension state, after 2 hours, part of it sinks, the sedimentation ratio is unqualified, and the taste is bitter.

Embodiment 2

[0025] Each bag contains meclofenoxate hydrochloride 100mg, and its prescription is:

[0026]

[0027] The preparation process is as follows: weigh meclofenoxate hydrochloride, xanthan gum, mannitol, sucralose, pregelatinized starch, and sodium hydroxypropylmethylcellulose E-15, pass through a 100-mesh sieve, and mix well to obtain dry suspension.

[0028] Evaluation: Weigh 1g of meclofenoxate hydrochloride dry suspension, add 20ml of hot water to stir and disperse, observe its suspension state, after 2 hours the suspension state is better, the sedimentation ratio is qualified, but the taste is bitter.

Embodiment 3

[0030] Each bag contains meclofenoxate hydrochloride 100mg, and its prescription is:

[0031]

[0032] The preparation process is as follows: weigh meclofenoxate hydrochloride, xanthan gum, mannitol, sucralose, pregelatinized starch, and sodium hydroxypropylmethylcellulose E-15, pass through a 100-mesh sieve, and mix well to obtain dry suspension.

[0033] Evaluation: Weigh 1g of meclofenoxate hydrochloride dry suspension, add 20ml of hot water to stir and disperse, and observe its suspension state. After 2 hours, the suspension state is better, the sedimentation ratio is qualified, and the taste is still a bit bitter.

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PUM

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Abstract

The invention belongs to the technical field of medicines, and relates to a meclofenoxate hydrochloride dry suspension and a preparation method thereof. The meclofenoxate hydrochloride dry suspension is used for treating traumatic coma, alcoholism, neonatal anoxia and child enuresis. The meclofenoxate hydrochloride dry suspension has a relatively-good taste, is simple and feasible in preparation process, and is more suitable for old patients and child patients when compared with the preparation products on sale at present.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a meclofenoxate hydrochloride dry suspension and a preparation method thereof, which are used for treating traumatic coma, alcoholism, neonatal hypoxia, and children's enuresis. Background technique [0002] Diabetes mellitus is a chronic disease of carbohydrate, fat and protein metabolism disorder caused by relative or absolute deficiency of insulin or decreased sensitivity of target cells to insulin, or structural defects of insulin itself. Its main features are hyperglycemia and diabetes, clinically manifested as polydipsia, polyphagia, polyuria, and weight loss (ie "three more and one less"), which can cause morphological changes and dysfunction of some tissues or organs, and ketones Acidosis, limb gangrene, polyneuritis, blindness and renal failure. Metformin hydrochloride is a biguanide oral hypoglycemic drug, which can reduce glycated hemoglobin and hyperinsulinem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/221A61P25/00A61P39/00A61P13/00
Inventor 赵伟王红霞王伟平李化淋
Owner 天津市聚星康华医药科技有限公司
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