Applications of arctigenin on preparing drugs for curing atherosclerosis or myocardial infarction

A technology of atherosclerosis and arctigenin, which is applied in the field of medicine to achieve good therapeutic effects, overcome the first-pass effect, and have obvious effects

Active Publication Date: 2014-01-01
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Arctigenin has significant antibacterial, antiviral, antitumor, and anti-PAF receptor ef

Method used

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  • Applications of arctigenin on preparing drugs for curing atherosclerosis or myocardial infarction
  • Applications of arctigenin on preparing drugs for curing atherosclerosis or myocardial infarction
  • Applications of arctigenin on preparing drugs for curing atherosclerosis or myocardial infarction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The preparation of embodiment 1 tablet

[0035]

[0036] Preparation process: mix arctigenin, auxiliary materials microcrystalline cellulose and sodium carboxymethyl starch evenly, add appropriate amount of starch slurry to make soft material, and pass through a 16-mesh sieve to granulate. The wet granules are dried at 60°C, the dry granules are passed through a 20-mesh sieve for granulation, the fine powder in the dry granules is screened out, mixed with magnesium stearate, and then mixed with the dry granules, pressed into tablets, each tablet is about 200mg, that is, .

Embodiment 2

[0037] The preparation of embodiment 2 injection

[0038] Arctigenin 10g

[0039] Tween 80 1g

[0040] Paraffin water for injection 1000mL

[0041] Preparation process: Mix 10g arctigenin and 1g Tween evenly, add water for injection to 1000mL, and divide into packages.

Embodiment 3

[0042] The preparation of embodiment 3 capsules

[0043] Arctigenin 100g

[0044] Lactose 120g

[0045] Cornstarch 130g

[0046] Magnesium Stearate 5g

[0047] Preparation process: 100g of arctigenin, 120g of lactose and 130g of corn starch are mixed in a mixer for 10-15 minutes, 5g of magnesium stearate is added and mixed for 1-3 minutes, and then filled into 1000 capsule shells.

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Abstract

The invention discloses applications of arctigenin on preparing drugs for curing atherosclerosis or myocardial infarction, and belongs to the field of medicine. In the novel medical application disclosed by the invention of arctigenin, the dosage amount of arctigenin is 0.001 to 200 mg/kg for each day, arctigenin can be made into oral preparations, injection preparations, or external preparations, wherein the oral micro-emulsion preparation of arctigenin has the best effect. The arctigenin has the advantages of little by-effect, prominent curing advantage, and high drug compliance of patients, and has a very vast medical application prospect.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a medicine for treating atherosclerosis or myocardial infarction. Background technique [0002] Atherosclerosis (Arteriosclerosis, AS) is a systemic disease related to lipid metabolism disorders, characterized by lipid deposition in the intima of large and medium arteries, atherosclerotic plaque formation, fibrous tissue hyperplasia, and arterial wall sclerosis. The harm of atherosclerosis can lead to vascular stasis and narrowing and insufficient blood supply on the one hand, and on the other hand, the greater harm lies in the rupture of plaques and the formation of thrombus, resulting in tissue ischemia and hypoxia, and in severe cases, death of patients. Patients with atherosclerosis are more common in the elderly. The detection rates of AS in 40-49 years old are 58.36% and 88.31% respectively, and increase with age. It is a common disease that seriously endangers human health. Among t...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P9/10
Inventor 赵志全姚景春王恩力孙敬侠刘奋董艳红
Owner LUNAN PHARMA GROUP CORPORATION
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