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A kind of florfenicol dry suspension and its preparation method and application

A florfenicol and suspension technology, which is used in pharmaceutical formulations, medical preparations containing active ingredients, antibacterial drugs, etc., can solve the problems of animal stress response, increased administration cost, insufficient preparation stability, etc. , to achieve the effect of improving dispersibility, improving animal compliance, and facilitating storage and transportation

Active Publication Date: 2016-02-03
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most dosage forms require multiple administrations to maintain a long enough effective drug concentration, and repeated administrations will increase the cost of administration and cause stress in animals
Although the suspension can achieve good drug utilization, yet, due to the existence of water in the liquid preparation, the stability of its preparation is always insufficient.

Method used

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  • A kind of florfenicol dry suspension and its preparation method and application
  • A kind of florfenicol dry suspension and its preparation method and application
  • A kind of florfenicol dry suspension and its preparation method and application

Examples

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Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 dry suspension of the present invention

[0022] prescription composition

[0023] Florfenicol 10g, sodium citrate 8g, sodium carboxymethylcellulose 6g, mannitol 20g, milk essence 0.5g, sucrose powder 55.5g.

[0024] Preparation Process

[0025] (1) Take the prescribed amount of florfenicol, sodium citrate, sucrose powder, sodium carboxymethylcellulose (CMC-NA), and mannitol, dry them separately, mix them evenly, pass through a 200-mesh sieve, and set aside.

[0026] (2) Take the mixed powder prepared in (1), make a soft material with 60% ethanol and granulate it with an 18-mesh sieve, dry it in an oven at 60°C, add the prescribed amount of milk essence, and pack 100g after whole grain , that is.

Embodiment 2

[0027] The preparation of embodiment 2 dry suspensions of the present invention

[0028] prescription composition

[0029] Florfenicol 8g, sodium citrate 9g, sodium carboxymethylcellulose 8g, mannitol 25g, milk essence 1g, sucrose powder 48g.

[0030] Preparation Process

[0031] (1) Take the prescribed amount of florfenicol, sodium citrate, sucrose powder, sodium carboxymethylcellulose (CMC-NA), and mannitol, dry them separately, mix them evenly, pass through a 200-mesh sieve, and set aside.

[0032] (2) Take the mixed powder prepared in (1), make a soft material with 60% ethanol and granulate it with an 18-mesh sieve, dry it in an oven at 60°C, add the prescribed amount of milk essence, and pack 100g after whole grain , that is. The preparation of embodiment 3 dry suspensions of the present invention

Embodiment 3

[0032] (2) Take the mixed powder prepared in (1), make a soft material with 60% ethanol and granulate it with an 18-mesh sieve, dry it in an oven at 60°C, add the prescribed amount of milk essence, and pack 100g after whole grain , that is. The preparation of embodiment 3 dry suspensions of the present invention

[0033] prescription composition

[0034] Florfenicol 12g, sodium citrate 7g, sodium carboxymethylcellulose 8g, mannitol 25g, milk essence 1g, sucrose powder 48g.

[0035] Preparation Process

[0036] (1) Take the prescribed amount of florfenicol, sodium citrate, sucrose powder, sodium carboxymethylcellulose (CMC-NA), and mannitol, dry them separately, mix them evenly, pass through a 200-mesh sieve, and set aside.

[0037] (2) Take the mixed powder prepared in (1), make a soft material with 60% ethanol and granulate it with an 18-mesh sieve, dry it in an oven at 60°C, add the prescribed amount of milk essence, and pack 100g after whole grain , that is. The formul...

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Abstract

The invention provides a florfenicol dry suspension, which is composed of the following raw materials by weight: 8-12 parts of florfenicol, 7-9 parts of sodium citrate, 20-25 parts of mannitol, 0.5-1 part of milk essence, 48-55.5 parts of a sucrose powder and 6-8 parts of carboxymethyl cellulose or hydroxypropyl methyl cellulose. The florfenicol dry suspension prepared by the invention significantly improves the dispersion of florfenicol in water, increases the utilization rate of the drug, ensures good taste and improves animal compliance; at the same time, the dry suspension provided by the invention has good stability, is easy for product storage and transportation, and provides a new choice for veterinary medicine.

Description

technical field [0001] The invention relates to a florfenicol dry suspension, a preparation method and application thereof. Background technique [0002] Florfenicol (Florfenicol) Chinese name: Fluorfen; Florfenicol; Fluorfenicol. Florfenicol is a new veterinary-specific broad-spectrum antibacterial drug of chloramphenicol successfully developed in the late 1980s, and it is the third-generation product of chloramphenicol. Its mechanism of action and antibacterial spectrum are similar to those of chloramphenicol and thiamphenicol. It can combine with 50S subunit to inhibit phthaloyltransferase, thereby inhibiting the extension of phthalein chain and interfering with protein synthesis. It is used for the prevention and treatment of asthma, contagious pleuropneumonia, atrophic rhinitis, porcine pneumonia, streptococcal disease, etc. caused by pigs, such as dyspnea, elevated body temperature, cough, choking, decreased feed intake, and emaciation. Curative effect, it has signif...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K31/165A61P31/04
Inventor 徐莎杨海涵房春林丁晓刚李超吴学渊
Owner CHENGDU QIANKUN VETERINARY PHARMA