Fukang expandable vaginal suppository, and preparation method and detection method thereof

A vaginal expansion suppository and detection method technology, applied in the field of vaginal suppositories, can solve the problems of outflow of active ingredients, unfavorable molding, and reduction of suppository bioavailability, and achieve the effect of avoiding secondary infection and preventing outflow

Active Publication Date: 2014-01-22
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The curative effect of Fukang Suppository has been clinically confirmed for many years, but the walnut distilled oil in traditional Fukang Suppository is volatile and has low solubility, which leads to low content of active ingredients in the suppository and affects the bioavailability of the suppository; and the walnut distilled oil The suppository made of oil and glycerin gelatin is irritating to mucous membrane; To improve the odor and solubility of walnut distilled oil, the adopted technical solutions include: CN103238680 discloses that walnut distilled oil is made into microcapsules, CN1362107 discloses that walnut oil is nanometerized, and CN102178240 discloses that walnut distilled oil is made into microemulsions After walnut distillate oil is carried out mic

Method used

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  • Fukang expandable vaginal suppository, and preparation method and detection method thereof
  • Fukang expandable vaginal suppository, and preparation method and detection method thereof
  • Fukang expandable vaginal suppository, and preparation method and detection method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088]

[0089] Preparation:

[0090] 1) Preparation of drug-containing matrix:

[0091] a. heating and melting the glycerin gelatin in a water bath to obtain a melt;

[0092]b. adding walnut distillate oil to the melt in step a under stirring, and mixing evenly to obtain a drug-containing matrix;

[0093] 2) Preparation of expansive suppositories: Pour the drug-containing matrix into a suppository mold, insert a tampon, cool and shape, and make 100 duckbill-shaped suppositories, each weighing about 4.5g.

Embodiment 2

[0095]

[0096] Preparation method: make 100 cylindrical suppositories according to the method described in Example 1, each weighing about 3.3 g .

Embodiment 3

[0098]

[0099] Preparation:

[0100] 1) Preparation of drug-containing matrix:

[0101] a. Place tallow tallow and hydrogenated peanut oil in a water bath to heat and melt, and mix uniformly to obtain a melt;

[0102] b. Preparation of traditional Chinese medicine extract: Weigh the motherwort and Polygonatum odoratum of the prescribed amount, add 75% ethanol to reflux and extract twice, the amount of ethanol added for the first time is 10 times the total weight of Motherwort and Polygonatum odoratum, reflux for 2 hours, and the second time The amount of ethanol added is 5 times of the total weight of Leonurus and Polygonatum odoratum, refluxed for 1 hour, combined the reflux liquid, filtered, the filtrate was concentrated to a clear paste, added water, stood still for 24 hours, recovered the precipitate, sprayed and dried into fine powder, and obtained the Chinese medicine extract;

[0103] c. adding the Chinese medicine extract and walnut distillate oil to the melt in s...

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Abstract

The invention relates to a Fukang expandable vaginal suppository, and a preparation method and a detection method thereof. The expandable suppository comprises active ingredients, a matrix and an expansion carrier. The active ingredients and the matrix form a drug-containing matrix, which is coated on the surface of the carrier. The active ingredients include walnut oil and further include motherwort and radix polygonati officinalis. The additional motherwort and radix polygonati officinalis can improve the curative effect of the Fukang expandable vaginal suppository on symptoms of leukorrhea with reddish discharge and bearing-down pain in lower abdomen; the starch sodium glycolate and walnut oil are prepared into a solid dispersion to improve the solubility of walnut oil and reduce volatilization of walnut oil; the stearic acid palmitic acid glycol ester improve the stability of the suppository; and the dextrin increases cohesiveness of the expandable suppository and is beneficial to forming the expandable suppository. The Fukang expandable vaginal suppository employs six unique technologies, and has beneficial effects of prevention of outflow liquid, high stability, lasting curative effect and prevention of secondary infection.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a Fukang vaginal expansion suppository and a preparation method and detection method thereof. Background technique [0002] Fukang suppository is a classic Chinese patent medicine, which is recorded in the seventeenth volume of "Ministry of Health's Drug Standards for Traditional Chinese Medicine Prescriptions". , has the effects of clearing heat and detoxifying, astringent and astringent, and is clinically used for red and white vaginal discharge, lower abdominal pain, and cervical erosion. [0003] The curative effect of Fukang Suppository has been clinically confirmed for many years, but the walnut distilled oil in traditional Fukang Suppository is volatile and has low solubility, which leads to low content of active ingredients in the suppository and affects the bioavailability of the suppository; and the walnut distilled oil The suppository made of oil and glycerin gela...

Claims

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Application Information

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IPC IPC(8): A61K36/52A61K36/8969A61K9/02A61K47/44A61K47/42A61K47/36A61K47/34A61K47/14G01G17/00G01N30/02G01N33/15A61P15/00
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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