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Cefoperazone sodium composition freeze-dried powder for injection

A technology of cefoperazone sodium and freeze-dried powder injection, which is applied in the field of pharmaceuticals and pharmaceutical manufacturing, can solve the problems of insensitivity to β-lactamase bacteria and poor curative effect, achieve the elimination of active effects, shorten the medication cycle, and reduce the occurrence of adverse reactions effect of possibility

Inactive Publication Date: 2014-01-29
HAINAN WEI KANG PHARMA QIANSHAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The object of the present invention is aimed at the cefoperazone sodium antibacterial drug containing a single component, which is insensitive to β-lactamase bacteria and has poor curative effect, and provides a cefoperazone sodium antibacterial drug composition with a wider antibacterial spectrum and stronger antibacterial effect and its antibacterial drug composition. pharmaceutical preparations

Method used

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  • Cefoperazone sodium composition freeze-dried powder for injection
  • Cefoperazone sodium composition freeze-dried powder for injection
  • Cefoperazone sodium composition freeze-dried powder for injection

Examples

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Effect test

Embodiment 1

[0028] Embodiment 1, preparation of cefoperazone sodium composition freeze-dried powder for injection, in 1000 pieces.

[0029] prescription:

[0030] Cefoperazone Sodium 40g

[0031] Chitosan Nanoparticles 24g

[0032] Water for injection 2000ml

[0033] 2. Preparation process:

[0034] The chitosan nanoparticle that takes by weighing 24g is slowly added in the water for injection of 2000ml, stirs while adding to dissolve.

[0035] Add 40 g of cefoperazone sodium and stir to dissolve until clear.

[0036] Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to cefoperazone sodium 40mg per bottle to calculate the filling volume.

[0037] Fill according to the test requirements, put it into a freeze dryer after half-tam...

Embodiment 2

[0038] Embodiment 2, preparation of cefoperazone sodium composition freeze-dried powder for injection, in 1000 pieces.

[0039] 1. Prescription:

[0040] Cefoperazone Sodium 40g

[0041] Chitosan Nanoparticles 30g

[0042] Water for injection 2000ml

[0043] 2. Preparation process:

[0044] The chitosan nanoparticle that takes by weighing 30g is slowly added in the water for injection of 2000ml, stirs while adding to dissolve.

[0045] Add 40 g of cefoperazone sodium and stir to dissolve until clear.

[0046] Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to cefoperazone sodium 40mg per bottle to calculate the filling volume.

[0047] Fill according to the test requirements, put it into a freeze dryer after half-...

Embodiment 3

[0048] Embodiment 3, preparation of lyophilized powder injection of cefoperazone sodium composition for injection, in 1000 pieces.

[0049] prescription:

[0050] Cefoperazone Sodium 40g

[0051] Chitosan Nanoparticles 18g

[0052] Water for injection 2000ml

[0053] 2. Preparation process:

[0054] The chitosan nanoparticle that takes by weighing 18g is slowly added in the water for injection of 2000ml, stirs while adding to dissolve.

[0055] Add 40 g of cefoperazone sodium and stir to dissolve until clear.

[0056] Adjust the pH to 5.1 with buffer salts of sodium dihydrogen phosphate and disodium hydrogen phosphate, add 0.1% activated carbon and stir for 30 minutes, filter out the activated carbon, and filter the liquid through 0.45 μm and 0.22 μm microporous membranes to detect the content of intermediates , according to cefoperazone sodium 40mg per bottle to calculate the filling volume.

[0057] Fill according to the test requirements, put it into a freeze dryer af...

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Abstract

The invention provides a cefoperazone sodium composition freeze-dried powder for injection, and belongs to the field of medicine and medicine preparation technology. The cefoperazone sodium composition freeze-dried powder comprises following raw material ingredients, by weight, 7.26 to 9.17 parts of cefoperazone sodium, 4.36 to 5.50 parts of chitosan nanoparticle, and 84.38 to 89.10 parts of injection water. Advantages of the cefoperazone sodium composition freeze-dried powder are that: 1) antibacterial activity of the cefoperazone sodium composition is increased significantly; 2) antibacterial spectrum is widened, and drug tolerance is reduced greatly; 3) improvement of activity is capable of shortening medication cycle of patients, and reducing occurrence likelihood of adverse reaction caused by accumulation of cefoperazone sodium; and 4) the chitosan nanoparticle can be used as a freeze-dried skeleton agent of the freeze-dried powder injection instead of mannitol, so that active effects of mannitol on human bodies are avoided.

Description

Technical field: [0001] The invention relates to the technical field of medicine and medicine manufacture, in particular to a cefoperazone sodium composition freeze-dried powder for injection. Background technique: [0002] Cefoperazone sodium is the third-generation broad-spectrum semi-synthetic cephalosporin, which can resist the degradation of various β-lactamases. It has a wide antibacterial spectrum and strong antibacterial effect. Unreasonable application causes bacteria to develop drug resistance, and drug-resistant strains gradually increase, which has become a major problem in clinical drug use. Its drug resistance is mainly due to the instability of cefoperazone sodium to hyperspectral lactamase produced by bacteria. [0003] Chitosan is an amino polysaccharide polymer obtained by deacetylating natural inactive chitin. The structure of chitosan is very similar to that of cellulose, except that the acetylamino group on the C2 sugar ring replaces the hydroxyl group...

Claims

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Application Information

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IPC IPC(8): A61K9/19A61K31/546A61K31/722A61K47/36A61P31/04
Inventor 汪六一汪金灿查龙飞
Owner HAINAN WEI KANG PHARMA QIANSHAN
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