Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Gadolinium-containing silicon dioxide nanosphere magnetic resonance contrast agent and preparation method thereof

A magnetic resonance contrast agent, silicon dioxide technology, applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agent, emulsion delivery, drug delivery, etc., can solve poor particle size distribution control, limit the application of contrast agents, and irregular morphology problems such as high particle size uniformity, regular shape, and reduced gadolinium content

Inactive Publication Date: 2012-01-25
SHANGHAI NAT ENG RES CENT FORNANOTECH
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In terms of preparing gadolinium-containing silica composite materials, the patent publication number CN1692947 discloses a nanocomposite preparation method of gadolinium-doped silica, using method, silica nanoparticles are formed in an alkaline solution mixed with GdCl3, and a rod-shaped particle with a particle size of 20-150 nm is prepared, but its shape is irregular, the dispersion is poor, and the particle size distribution is less controlled. Poor, and low encapsulation efficiency, which limits its application as a developer

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Gadolinium-containing silicon dioxide nanosphere magnetic resonance contrast agent and preparation method thereof
  • Gadolinium-containing silicon dioxide nanosphere magnetic resonance contrast agent and preparation method thereof
  • Gadolinium-containing silicon dioxide nanosphere magnetic resonance contrast agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Mix 7.5ml of oil phase cyclohexane and 1.8ml of surfactant polyethylene glycol octyl phenyl ether (Triton X-100) and stir vigorously until uniform, then add 150 μl of gadopentetate dimegure After the amine solution (469.01 mg / ml) and 240 μl of ammonia water (25 wt%) were mixed evenly, they were slowly dropped into the oil phase under the condition of ultrasonic and stirring at a speed of 400 rpm, and the ultrasonic stirring was continued for 30 minutes until the microemulsion was formed. Under stirring at a speed of 400 rpm, 100 μl of tetraethyl orthosilicate (TEOS) was slowly added, and stirring was continued for 3 h. The microemulsion system was placed in a dark place and aged at room temperature for 24 hours. After the reaction is completed, add acetone to break the emulsion, centrifuge at high speed and discard the supernatant, then wash with absolute ethanol at least 5 times, ultrasonically disperse in deionized water, freeze-dry to obtain the water-solu...

Embodiment 2

[0034] Embodiment 2: Mix 10ml oil phase liquid paraffin, 100μl surfactant sorbitol stearate (Span80), and stir vigorously until uniform, then mix 10μl gadoteric acid meglumine solution (50mg / ml) and 50μl hydrogen After the sodium oxide solution (5wt%) was mixed evenly, it was slowly dropped into the oil phase under ultrasonic and stirring at a speed of 100 rpm, and continued ultrasonic stirring for 30 minutes until the microemulsion was formed. Under stirring at a speed of 100 rpm, 50 μl of tetraethyl orthosilicate (TEOS) was slowly added, and stirring was continued for 3 h. The microemulsion system was placed in a dark place and aged at room temperature for 24 hours. After the reaction is complete, add acetone to break the emulsion, centrifuge at high speed and discard the supernatant, then wash with absolute ethanol at least 5 times, and then ultrasonically disperse in deionized water to obtain water-soluble silica doped with gadolinium-containing preparations nanosphere su...

Embodiment 3

[0035] Embodiment three: 10ml oil phase sherwood oil, 4ml surfactant sorbitol stearate (Span80) are mixed, and vigorously stirred to uniform, then 800 μ l Gd-DTPA chelate solution (1000mg / ml) and 1ml hydrogen After the sodium oxide solution (30wt%) was mixed evenly, it was slowly dropped into the oil phase under the condition of ultrasonic and stirring at a speed of 500 rpm, and the ultrasonic stirring was continued for 30 minutes until the microemulsion was formed. Under stirring at a speed of 500 rpm, 1 ml of tetraethyl orthosilicate (TEOS) was slowly added, and stirring was continued for 3 h. The microemulsion system was placed in a dark place and aged at room temperature for 48 hours. After the reaction is complete, add acetone to break the emulsion, centrifuge at high speed and discard the supernatant, then wash with absolute ethanol at least 5 times, ultrasonically disperse in deionized water, freeze-dry to obtain the water-soluble Silica nano microsphere powder.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a gadolinium-containing silicon dioxide nanosphere magnetic resonance contrast agent for lymphatic system specific imaging and a preparation method thereof. The contrast agent is nanosphere suspend liquid or powder formed by using water-soluble silicon dioxide to cover preparation containing gadolinium, wherein the particle size ranges from 50nm to 200nm; the weight ratioof the preparation containing gadolinium to the water-soluble silicon dioxide is between 1.86X10<-4> and 0.592. The nanosphere prepared by the invention has relatively high entrapment efficiency, canselectively enter Lymphatic capillaries but not capillary vessel, thereby being used for the lymphatic system specific imaging, reducing the interference of the capillary vessel, improving the sensitivity and specificity of the lymphatic qualitative diagnosis, as well as reducing the harm thereof to human body, therefore, the nanosphere magnetic resonance contrast agent is a new gadolinium-containing magnetic resonance contrast agent with high target.

Description

Technical field: [0001] The invention relates to a novel gadolinium-containing magnetic resonance contrast agent and a preparation method thereof, in particular to a water-soluble silica nano-microsphere contrast agent doped with a gadolinium-containing preparation for specific imaging of the lymphatic system and a preparation method thereof. Background technique: [0002] With the development of micro-lymphatic surgery technology, higher requirements are put forward for the classification and localization diagnosis of lymphatic reflux disorders; at the same time, it is more accurate and sensitive to display the structure of lymphatic vessels and lymph nodes, and judge their functional status Accurate staging of tumor patients is the basis for formulating treatment plans, judging prognosis, and effectively preventing postoperative lymphedema, and is the key to diagnosis and treatment of lymphatic system diseases. Lymphography has always been considered the "gold standard" fo...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06A61K49/08A61K49/18
Inventor 胡劲刘晓晟沈新程许建荣金彩虹何丹农
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com