Vinyl cyclohexyl methyl ether liquid crystal compounds and preparation method thereof
A technology of liquid crystal compound and hexyl methyl ether, which is applied in the field of fine chemical industry and material chemistry, can solve the problems of unrelated compounds and insufficient range of liquid crystal, and achieve the effect of large dielectric anisotropy, lower threshold voltage and lower driving voltage
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[0082] 2, Preparation of methyl 4-formylcyclohexylcarboxylate
[0083]
[0084] Experimental device: 1 liter three-neck flask, equipped with a thermometer, stirring, N 2 Protection, ice water bath.
[0085] Operation process: Add 56.8g of the above product and 200mL of THF into a three-necked bottle, add 500mL of 5% hydrochloric acid dropwise, and control the temperature below 10°C. After the dropwise addition is completed, heat to 30° C. and keep the temperature for 4 hours. Add 200mL water, with 200mL CH 2 Cl 2 Extract, wash with water until neutral, add anhydrous Na 2 SO 4 Dry and remove the solvent with a rotary evaporator to obtain 48.5 g of light yellow liquid, yield: 96.0%, GC purity: 90.2%.
[0086] 3, Preparation of methyl 4-vinylcyclohexylcarboxylate
[0087]
[0088] Experimental device: 2-liter three-neck flask, equipped with a thermometer, stirring, liquid seal, N 2 Protect, dry tube.
[0089] Operation process: add CH to the three-necked bottle 3 ...
Embodiment 1
[0102] Embodiment 1: Preparation of VC10PUF
[0103] 1. Preparation of OHPUF
[0104]
[0105] Method a: Experimental equipment: 500mL three-neck flask, liquid seal, mechanical stirring, thermometer at 0-100°C, reflux condenser, drying tube.
[0106] Operation process: Add 27.6g of potassium carbonate and 55g of water into the three-necked flask under nitrogen protection, stir and put in 17.6g of 3,4,5-trifluorophenylboronic acid, 17.3g of p-iodophenol, 0.224g of tetrakistriphenylphosphine Palladium and 80g of toluene were incubated at 70-90°C for 3 hours. After the reaction, 200mL of water was added to the system and transferred to a separatory funnel. The organic phase was washed with water until neutral, and the solvent was removed by a rotary evaporator to obtain 26g of a crude product. Toluene and n-hexane were recrystallized once to obtain 19.6 g of the product, with a yield of 87.0% and a GC purity of 98.2%.
[0107] Method b: Experimental device: 500mL three-neck...
Embodiment 2
[0119] Embodiment 2: Preparation of VC10UUF
[0120] 1. Preparation of VC10U
[0121]
[0122] Method a: Experimental equipment: 500mL three-neck flask, liquid seal, mechanical stirring, 0-300°C thermometer, reflux condenser, drying tube.
[0123] Operation process: Add 50g VCMI, 27.3g 3,5-difluorophenol, 22.4g potassium hydroxide and 200g toluene to the three-necked flask under the protection of nitrogen, raise the temperature to reflux, keep the temperature for 10h, after the reaction, cool down to room temperature, and pour into the system Add 200mL of water, transfer to a separatory funnel, wash the organic phase with water until neutral, and remove the solvent by a rotary evaporator to obtain 48g of the product, recrystallize twice with toluene and absolute ethanol to obtain 43.7g of the product, with a yield of 87.0%, GC purity 96.4%.
[0124] Method b: Experimental device: 500mL three-neck flask, liquid seal, mechanical stirring, thermometer at 0-300°C, reflux con...
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