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Preparation method of injectable self-curing hypoglycemic hydrogel

A hydrogel and hypoglycemic technology, applied in the field of biomedical engineering, to achieve the effects of cost reduction, stable degradation rate and stable drug release

Inactive Publication Date: 2014-02-05
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] To sum up, in the reports of the existing literature, there is no information about the chemical modification of dextran and PEG as the main raw materials in the present invention to obtain their derivatives, and the controllable gelation time obtained through the Diels-Alder reaction. The self-curing hydrogel material, and the hypoglycemic drug is loaded on the hydrogel material, and the biodegradable hydrogel injection with long-term slow-release hypoglycemic drug under the stimulation of the in vivo physiological environment is obtained. related research reports

Method used

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  • Preparation method of injectable self-curing hypoglycemic hydrogel
  • Preparation method of injectable self-curing hypoglycemic hydrogel
  • Preparation method of injectable self-curing hypoglycemic hydrogel

Examples

Experimental program
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Effect test

Embodiment 1

[0024]Add 5.0 g of dextran, 2.0 g of lithium chloride, and 100 mL of anhydrous DMF into the reaction vessel, raise the temperature to 90°C, stir until completely dissolved, stop heating and drop to room temperature, then add 0.9 g of pyridine, and place in an ice bath Add 2.2 g of PNC in batches, react at room temperature for 24 h (the reaction process is carried out under the protection of nitrogen), under the condition of ice bath, drop the reaction solution into 200 mL of ethanol, filter the solid, wash with ethanol several times, and use Wash with ether and dry under vacuum at room temperature to obtain a dextran intermediate (DP6) with a substitution degree of 6%. Weigh 2 g of DP6 and add 80 μL of furfurylamine to 40 mL of anhydrous DMF, and react at room temperature for 48 h . Under the condition of ice bath, the reaction solution was dropped into 50 mL of ethanol, the solid was collected by suction filtration, washed with ethanol several times and then washed with ether...

Embodiment 2

[0026] Add 5.0 g of dextran, 2.0 g of lithium chloride, and 100 mL of anhydrous DMF to the reaction vessel, raise the temperature to 90°C, stir until completely dissolved, stop heating and cool down to room temperature, then add 1.8 g of pyridine, and place in an ice bath Add 4.4 g of PNC in batches, react at room temperature for 24 h (the reaction process is carried out under nitrogen protection), under ice bath conditions, the reaction solution is dripped into 200 mL of ethanol, and the solid is collected by suction filtration, washed with ethanol for several times Wash with ether and dry under vacuum at room temperature to obtain a dextran intermediate (DP15) with a substitution degree of 15%. Weigh 2 g of DP15, add 20 mL of anhydrous DMF, and add 180 μL of furfurylamine after complete dissolution, and react at room temperature for 48 h . Under the condition of ice bath, the reaction solution was dropped into 50 mL of ethanol, the solid was collected by suction filtration, ...

Embodiment 3

[0028] Add 5.0 g of dextran, 2.0 g of lithium chloride, and 100 mL of anhydrous DMF into the reaction vessel, raise the temperature to 90°C, stir until completely dissolved, stop heating and cool down to room temperature, then add 3.6 g of pyridine, and place in an ice bath Add 8.8 g of PNC in batches, react at room temperature for 24 h (the reaction process is all carried out under the protection of nitrogen), under the condition of ice bath, drop the reaction solution into 200 mL of ethanol, filter the solid, wash with ethanol several times and use Wash with ether and dry under vacuum at room temperature to obtain a dextran intermediate (DP60) with a substitution degree of 60%. Weigh 2 g of DP60, add 20 mL of anhydrous DMF, and add 230 μL of furfurylamine after complete dissolution, and react at room temperature for 48 h . Under the condition of ice bath, the reaction solution was dropped into 50 mL of ethanol, the solid was collected by suction filtration, washed with ethan...

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Abstract

The invention belongs to the field of biomedical science, and particularly relates to a preparation method of injectable self-curing hypoglycemic hydrogel. The preparation method is characterized in that dextran (Dex) and polyethylene glycol (PEG) are used as main raw materials and are subjected to chemical modification so as to obtain derivatives of the dextran and the polyethylene glycol, namely the furyl dextran derivative (DF) and the maleimide polyethylene glycol (Mal-PEG-Mal) derivative, the self-curing hydrogel material controlled in gelling time can be obtained through Diels-Alder reaction, and a hypoglycemic medicament comprising one or more of sulfonylureas, biguanides, insulin and the like is loaded on the hydrogel material. The purpose of stably controlling blood sugar for a long time is achieved by slowly releasing the hypoglycemic medicament, the morbidity of diabetic complications is reduced, and even the life span of patients is prolonged.

Description

technical field [0001] The invention belongs to the field of biomedical engineering, and in particular relates to a preparation method of an injectable self-curing hypoglycemic hydrogel. Background technique [0002] Diabetes mellitus is an absolute or relative deficiency of insulin in the blood, leading to hyperglycemia, diabetes, and a common endocrine and metabolic disease that causes fat and protein metabolism disorders. Due to the reform and opening up, the national lifestyle and dietary structure have changed. Since 2000, the incidence of diabetes in China has entered a period of rapid growth. Every day, tens of thousands of people become diabetics, and about 4,000 people die of various diseases caused by diabetes. a complication. Diabetes has become an important killer of Chinese people's health, and its onset tends to be younger, which is a huge burden on individuals, families and the country. The treatment of diabetes is usually to control blood sugar with a singl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K45/00A61K47/36A61K47/34A61P3/10C08G81/00C08B37/00
Inventor 赵鹏邓翠君林超文学军吕立夏
Owner TONGJI UNIV
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