Method of extracting and preparing lysine sulphate from fermenting liquid containing lysin

A lysine sulfate, lysine technology, applied in the preparation of organic compounds, chemical instruments and methods, cyanide reaction preparation and other directions, can solve the problem that the lysine sulfate aqueous solution is not easy to crystallize, the environmental pollution is large, and the process is cumbersome and other problems, to achieve the effect of low cost, low environmental pollution and simple process

Active Publication Date: 2014-02-05
安徽丰原集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to solve the technical difficulty that lysine sulfate is not easy to crystallize in the lysine sulfate aqueous solution and provide A simple, high-yield, low-cost method for preparing high-purity lysine sulfate

Method used

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  • Method of extracting and preparing lysine sulphate from fermenting liquid containing lysin
  • Method of extracting and preparing lysine sulphate from fermenting liquid containing lysin

Examples

Experimental program
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Effect test

Embodiment 1

[0031] like figure 1 Shown, the specific steps of the method of the present invention are as follows:

[0032] 1) Take 100L of heated fermentation broth, with a solid content of 25%, a lysine content of 18.5g / 100mL, and a pH value of 6.96.

[0033] 2) The fermentation broth is filtered with a 50nm ceramic membrane to remove bacteria. The inlet pressure of the membrane is 0.2Mpa, the outlet pressure is 0.15Mpa, the flux is 54.4LMH, the concentration is 5.9 times, and the amount of dialysis water is 30L. The dense phase I has a volume of 17L, a lysine content of 4.47g / 100mL, and a solid content of 13.3%.

[0034] 3) Ceramic membrane microfiltrate, solid content 20%, lysine content 15.1g / 100mL. The microfiltrate uses a 500D nanofiltration membrane for decolorization and impurity removal. The inlet pressure of the membrane is 2Mpa, the outlet pressure is 1.8Mpa, the flux is 17.6LMH, and the concentration is 8.8 times. The dense phase II has a volume of 12.5L, a solid content of...

Embodiment 2

[0039] like figure 1 Shown, the specific steps of the method of the present invention are as follows:

[0040] 1) Take 300L of heated fermentation broth, with a solid content of 22.3% (m / m), a lysine content of 16.5g / 100mL, and a pH value of 6.93.

[0041] 2) The fermentation broth is filtered with a 50nm ceramic membrane to remove bacteria. The inlet pressure of the membrane is 0.2Mpa, the outlet pressure is 0.15Mpa, the flux is 46LMH, concentrated to 6 times, and the amount of dialysis water is 100L. Dense phase I has a volume of 50L, a lysine content of 4.9g / 100mL, and a solid content of 15% (m / m).

[0042]3) 150L of ceramic membrane microfiltrate was applied mechanically to 5L of the previous batch of crystallization mother liquor, with a solid content of 16.9% (m / m) and a lysine content of 14.2g / 100mL. The microfiltrate uses a 500D nanofiltration membrane for decolorization and impurity removal. The inlet pressure of the membrane is 2Mpa, the outlet pressure is 1.8Mpa, ...

Embodiment 3

[0049] like figure 1 Shown, the specific steps of the method of the present invention are as follows:

[0050] 1) Take 500L of heated fermentation broth, with a solid content of 23.5% (m / m), a lysine content of 18.5g / 100mL, and a pH value of 6.97.

[0051] 2) The fermentation broth is filtered with a 50nm ceramic membrane to remove bacteria. The inlet pressure of the membrane is 0.2Mpa, the outlet pressure is 0.15Mpa, the flux is 65LMH, the concentration is 6 times, and the amount of dialysis water is 175L. The dense phase I has a volume of 83L, a lysine content of 4.1g / 100mL, and a solid content of 14.6% (m / m).

[0052] 3) 300L of ceramic membrane microfiltrate was applied to 10L of crystallization mother liquor from the previous batch, with a solid content of 17.5% (m / m) and a lysine content of 14.8g / 100mL. The microfiltrate uses a 500D nanofiltration membrane for decolorization and impurity removal. The inlet pressure of the membrane is 2Mpa, the outlet pressure is 1.8Mpa...

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Abstract

The invention discloses a method of extracting and preparing lysine sulphate from a fermenting liquid containing lysine. The method comprises micro-filtering the fermenting liquid containing lysine to remove thallus, decoloring and removing impurities by using a nanofiltration membrane, performing ion exchange by using a destaining solution to remove ions and ash content, concentrating, acidifying, cooling, crystallizing and drying an ion exchange liquid to obtain high-purity lysine sulphate with purity of being more than 98.5%. 65% of lysine sulphate is prepared by concentrating, spraying and drying after membrane dense phase and crystallization mother liquor are mixed. The lysine sulphate prepared by the method has the advantages of high yield, high product purity, simple process, simple operation and less environmental pollution.

Description

technical field [0001] The invention relates to the technical field of feed, in particular to a method for extracting and preparing high-purity lysine sulfate from a lysine-containing fermentation liquid. Background technique [0002] Lysine is the most important amino acid among the eight amino acids necessary for protein composition. Its chemical name is L-2,6-diaminocaproic acid, and its chemical structure is: [0003] [0004] Lysine cannot be synthesized by humans and animals, and it is also the most deficient amino acid in grains. It must be supplied from outside the body. substitute role. At the same time, it is also the second largest amino acid species after glutamic acid, which is what we often call monosodium glutamate. At present, the annual output of lysine hydrochloride products in the world has reached 1 million tons, of which about 90% are used as feed additives, and 10% are used as food and pharmaceutical intermediates. Therefore, it is very important ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/26C07C227/40
Inventor 李荣杰尚海涛纪传侠潘声龙张毅李银行王超
Owner 安徽丰原集团有限公司
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