Method for synthesizing resinous vitamin D3 by using micro-flow photoreaction technology and micro-flow photochemical reactor

A technology of chemical reactor and photochemical reaction, which is applied in the field of organic photochemical synthesis, can solve the problems of cumbersome processing process and complex structure of reaction device, and achieve the effect of simple and easy operation of the preparation process and large-scale production
CN103553993AActive Publication Date: 2014-02-05TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Publication Date
2014-02-05

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Abstract

The invention belongs to the field of organic photochemistry synthesis, and in particular relates to a method for synthesizing a resinous vitamin D3 by using a micro-flow photoreaction technology, and a micro-flow photochemical reactor for synthesizing the resinous vitamin D3. The method for synthesizing the resinous vitamin D3 by using the micro-flow photoreaction technology comprises the steps of performing illumination reaction in the micro-flow photochemical reactor under the protection of nitrogen (preferably high-purity nitrogen); controlling the temperature of a photochemical reaction solution during reaction to be lower than 28 DEG C, and adjusting and controlling the flow rate of the photochemical reaction solution in a micro-flow pipe by using a peristaltic pump, wherein the conversion rate of 7-dehydrocholesterol after the illumination reaction reaches 90.5-95%, and the HPLC (high-performance liquid chromatography) yield of a pre-vitamin D3 is improved to 70-73.1%. The resinous vitamin D3 is prepared through thermal isomerization reaction, and the HPLC yield of the resinous vitamin D3 is 68-71.1%. The whole preparation process is simple and easy to operate, so that large-scale production can be realized easily.
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Description

technical field

[0001] The invention belongs to the field of organic photochemical synthesis, in particular to the synthesis of resinous vitamin D using microfluidic reaction technology 3 method, and for the synthesis of resinous vitamin D 3 microfluidic photochemical reactor. Background technique

[0002] Vitamin D 3 It is one of the important vitamins essential for the normal growth and reproduction of humans, livestock, and poultry, and appropriate amounts of vitamin D need to be added to food and feed 3 . With the development of society and the improvement of people's living standards, vitamin D 3 It has broad market prospects both domestically and internationally.

[0003] In 2002, the applicant in this case invented the photochemical synthesis of vitamin D 3 method (ZL02104444.9), and successfully realized industrial production through Zhejiang Garden Group. The technology fills our VD 3 The technical gap in production has made our country become the master of ...

Claims

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