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A technology of granules and banqing, which is applied in the field of quality control of banqing granules, can solve the problems that the quality control of banqing granules is difficult to meet quantitative standards, the impact of safety and effectiveness of traditional Chinese medicine, and the difficulty of ensuring the quality of medicines, etc., to achieve quality The effect of level improvement, good linear relationship and good reproducibility
Active Publication Date: 2016-01-13
LUOYANG HUIZHONG ANIMAL MEDICINE
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Therefore, the quality control of Banqing granules is difficult to achieve quantitative standards
[0004] Banqing granule is a veterinary compound traditional Chinese medicine containing multiple components and complex components. Due to the complexity of the components, the content is difficult to control, which affects the safety and effectiveness of traditional Chinese medicine. If the quality control of the active ingredients cannot be carried out, it is difficult to guarantee the quality of the veterinary compound traditional Chinese medicine.
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Embodiment 1
[0028] Example 1 Simultaneous determination of the content of arginine and indirubin in Banqing granules by HPLC method 1 instrument, reagents, and samples
[0029] Instrument: Waterse2695 high performance liquid chromatograph; UV2489 ultraviolet detector.
[0030] Reagents: acetonitrile is chromatographically pure; phosphoric acid, potassium dihydrogen phosphate, and ethanol are analytically pure; water is double distilled water.
[0031] Reference substance: arginine (140685-200802), indirubin (110717-200204) purchased from China Veterinary Drug Administration
[0032] Sample: Banqing granules, produced by Luoyang Huizhong Veterinary Medicine Co., Ltd. {[Prescription] 600g Radix isatidis 600g Daqing Ye 900g [Preparation method] 2 flavors above, add water to decoc 2 times, 1 hour each time, combine the decoction, filter, concentrate the filtrate to a thick paste, add sucrose, dextrin, Mix well, make granules, dry, make 1500g, and get it.
[0033] 2 Chromatographic conditions:
[0034]...
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Abstract
The invention provides a kind of quality control method of Banqing granule, for using HPLC chromatographic method to measure arginine and indirubin content simultaneously, comprise the following steps: prepare respectively the standard sample of arginine and indirubin and the standard sample of Banqing granule Test sample; through HPLC chromatographic processing, comparative calculation obtains the content of arginine and indirubin in the test sample of Banqing granules. The method for controlling the content of Banqing granules of the present invention is simple to operate, realizes the quantitative control requirements for active ingredients in traditional Chinese medicine products with complex types of active ingredients, and improves the quality level of the products. The limit of arginine content per gram of granules is not less than 12.5mg / g, and indirubin is 0.12mg / g, which can be used as the standard for quality control of Banqing granules.
Description
Technical field [0001] The invention relates to a quality control method for Banqing granules, in particular to a method for realizing the quality control of Banqing granules by measuring the content of arginine and indirubin in Banqing granules. Background technique [0002] Banqing granules is a common veterinary prescription. The prescription contains Radix isatidis, Daqingye and other ingredients, which has the functions of clearing away heat and detoxifying, reducing swelling, strengthening the heart, diuresis and choleretic, anti-bacterial, anti-inflammatory, anti-virus, and enhancing immunity. Mainly used to prevent and treat swine influenza, high fever, reproductive and respiratory syndrome, parvovirus disease, hemorrhagic sepsis, erysipelas, streptococcus, paratyphoid, viral enteritis, eperythrocytosis, pseudorabies, and piglet weaning System failure syndrome and other immunosuppressive diseases. In addition, it is also effective in treating duck viral hepatitis, duck pl...
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