Quality control method for Qiqing toxin-removing particles
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A technology of particle quality and control method, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of complex ingredients, difficult to control content, influence on the safety and effectiveness of traditional Chinese medicine, and achieve the effect of simple operation and improved quality level.
Active Publication Date: 2014-02-12
LUOYANG HUIZHONG ANIMAL MEDICINE
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"The Veterinary Pharmacopoeia of the People's Republic of China" (2010 Part II) discloses a method for quality control of Qiqingbaidu granules using thin-layer chromatography, but the quality standard of Qiqingbaidu granules is only for baicalin, Polygonum cuspidatum, There are no specific content determination items for the identification of emodin, indigo and indirubin. Theref
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[0024] Example 1 Simultaneous determination of the contents of baicalin and emodin in Qiqingbaidu granules by HPLC
[0025] The HPLC chromatographic conditions in the embodiment of the present invention are:
[0026] Column: Agilent-C18 (150mm X 4.6mm, 5um).
[0027] Mobile phase: acetonitrile-water-phosphoric acid (22:78:0.2)
[0029] Preparation of reference solution: Take appropriate amounts of baicalin reference substance and emodin reference substance that have been dried under reduced pressure at 60°C for 4 hours, accurately weighed, and place them in the same 25ml measuring flask. Add 70% ethanol to dissolve and dilute to the mark. Shake well , Make a reference solution containing 0.3mg of baicalin and 20ug of emodin per ml.
[0030] Preparation of test product solution: Take about 0.2g of the finely ground test product, accurately weigh it, place it in a 25ml measuring flask, add 20ml of 70% etha...
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Abstract
The invention provides a method for simultaneous determination on content of astragalin and emodin by HPLC chromatography, so that the quality control on Qiqing toxin-removing particles is realized. The method comprises the following steps: respectively preparing standard samples of astragalin and emodin and a to-be determined sample of Qiqing toxin-removing particles; and processing the above samples according to HPLC chromatography, comparing and calculating to obtain the content of astragalin and emodin in the to-be determined sample of Qiqing toxin-removing particles. The method provided by the invention is improvement on the Qiqing toxin-removing particles quality control method in Chinese Veterinary Pharmacopoeia, Part II , 2010 edition; and the quality control method is simple in operation, helps to satisfy quantification control requirements of active ingredients in traditional Chinese medicine products with complex active ingredient kind, helps to improve the quality level of the products, and can be taken as a new standard method for quality control on Qiqing toxin-removing particles.
Description
technical field [0001] The invention relates to a quality control method of Qiqingbaidu granules, in particular to a method for simultaneously measuring the contents of astragaloside and emodin in Qiqingbaidu granules. Background technique [0002] Qiqingbaidu Granule is a common veterinary prescription, which has the functions of clearing away heat and detoxifying, drying dampness and stopping diarrhea. The prescription contains Scutellaria baicalensis, Polygonum cuspidatum, Pulsatilla, Sophora flavescens, Banlangen, Mianmaguanzhong, Daqingye, etc. It is mainly used for damp-heat diarrhea, pullorum in chicks, and also used to prevent and treat porcine reproductive and respiratory syndrome, mild swine fever, Circovirus, PRRS virus, influenza virus and avian mild influenza, atypical Newcastle disease, chronic respiratory disease, infectious bronchitis, infectious laryngotracheitis, bursal disease, egg drop syndrome, avian enterotoxic syndrome It also has the effects of enhan...
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