Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Quality control method for Qiqing toxin-removing particles

A technology of particle quality and control method, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of complex ingredients, difficult to control content, influence on the safety and effectiveness of traditional Chinese medicine, and achieve the effect of simple operation and improved quality level.

Active Publication Date: 2014-02-12
LUOYANG HUIZHONG ANIMAL MEDICINE
View PDF2 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"The Veterinary Pharmacopoeia of the People's Republic of China" (2010 Part II) discloses a method for quality control of Qiqingbaidu granules using thin-layer chromatography, but the quality standard of Qiqingbaidu granules is only for baicalin, Polygonum cuspidatum, There are no specific content determination items for the identification of emodin, indigo and indirubin. Therefore, it is difficult to achieve quantitative standards for quality control of Qiqingbaidu granules
[0003] Since Qiqingbaidu Granule is a veterinary compound Chinese medicine containing multiple components and complex ingredients, the content is difficult to control due to the complexity of the ingredients, which affects the safety and effectiveness of traditional Chinese medicine.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Quality control method for Qiqing toxin-removing particles
  • Quality control method for Qiqing toxin-removing particles
  • Quality control method for Qiqing toxin-removing particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1HPLC method simultaneously measures the content of baicalin and emodin in Qiqingbaidu granule

[0025] In the embodiment of the present invention, HPLC chromatographic condition is:

[0026] Chromatographic column: Agilent-C18 (150mm X 4.6mm, 5um).

[0027] Mobile phase: acetonitrile-water-phosphoric acid (22:78:0.2)

[0028] Flow rate: 1ml / min; detection wavelength: 270nm; column temperature: 35°C.

[0029] Preparation of reference substance solution: Take the appropriate amount of baicalin reference substance and emodin reference substance that were dried under reduced pressure at 60°C for 4 hours, weigh them accurately, put them in the same 25ml measuring bottle, add 70% ethanol to dissolve and dilute to the mark, shake well , make every milliliter contain the reference substance solution of baicalin 0.3mg, emodin 20ug.

[0030] Preparation of the test solution: Take about 0.2 g of the finely ground test sample, weigh it accurately, put it in a 25ml me...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a method for simultaneous determination on content of astragalin and emodin by HPLC chromatography, so that the quality control on Qiqing toxin-removing particles is realized. The method comprises the following steps: respectively preparing standard samples of astragalin and emodin and a to-be determined sample of Qiqing toxin-removing particles; and processing the above samples according to HPLC chromatography, comparing and calculating to obtain the content of astragalin and emodin in the to-be determined sample of Qiqing toxin-removing particles. The method provided by the invention is improvement on the Qiqing toxin-removing particles quality control method in Chinese Veterinary Pharmacopoeia, Part II , 2010 edition; and the quality control method is simple in operation, helps to satisfy quantification control requirements of active ingredients in traditional Chinese medicine products with complex active ingredient kind, helps to improve the quality level of the products, and can be taken as a new standard method for quality control on Qiqing toxin-removing particles.

Description

technical field [0001] The invention relates to a quality control method of Qiqingbaidu granules, in particular to a method for simultaneously measuring the contents of astragaloside and emodin in Qiqingbaidu granules. Background technique [0002] Qiqingbaidu Granule is a common veterinary prescription, which has the functions of clearing away heat and detoxifying, drying dampness and stopping diarrhea. The prescription contains Scutellaria baicalensis, Polygonum cuspidatum, Pulsatilla, Sophora flavescens, Banlangen, Mianmaguanzhong, Daqingye, etc. It is mainly used for damp-heat diarrhea, pullorum in chicks, and also used to prevent and treat porcine reproductive and respiratory syndrome, mild swine fever, Circovirus, PRRS virus, influenza virus and avian mild influenza, atypical Newcastle disease, chronic respiratory disease, infectious bronchitis, infectious laryngotracheitis, bursal disease, egg drop syndrome, avian enterotoxic syndrome It also has the effects of enhan...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): G01N30/88
Inventor 张许科刘兴金张晓会
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
Features
  • Generate Ideas
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com