Bioactive small peptide, synthesis method and use thereof as animal feed additive

Abstract

The invention relates to a bioactive small peptide, a synthesis method and use thereof as an animal feed additive. The bioactive small peptide is linear pentapeptide Tyr-Gly-Gly-Trp-Leu, and is synthetized by adopting a method of gradually combining a joint chain with a segment joint chain, and the obtained peptide is high in purity, can play a role when the adding concentration is very low and has the functions of adjusting animal gastrointestinal flora, promoting the animal digestive function, preventing digestive tract diseases, stimulating the immunologic function of an animal, enhancing the disease resistance of the animal on a plurality of epidemic diseases, greatly reducing the morbidity and the death and culling rate, reducing the production cost, facilitating growth and increasing the weight and is low in production cost.

Description

field of invention [0001] The invention relates to a bioactive small peptide feed additive, in particular to a bioactive small peptide feed additive and a preparation method thereof. Background technique [0002] In recent years, in order to one-sidedly pursue profits, some farms (households) have abused feed additives for the purpose of promoting growth, controlling diseases, and increasing lean meat, which not only affects the curative effect but also brings some adverse reactions: such as injection of thymosin preparations, Transfer factor preparations can cause fever and allergic reactions; large doses of lipopolysaccharide can cause immune tolerance; levamisole can cause loss of appetite, nausea, vomiting, abnormal sense of smell, lethargy, fever, allergic reactions, neutropenia, liver function exception etc. The "green technical barriers" of developed countries have seriously restricted my country's animal products from entering the international market. The proportio...

AI Technical Summary

Problems solved by technology

[0003] The bioactive small peptides currently available on the market as feed additives are peptide proteins processed from the small intestine and intestinal mucosa of animals or peptide protein feeds containing a certain amount of small peptides, rather than small bioactive peptides in the true sense. Although pure peptide products can also improve animal production performance and reduce diarrhea rate, most of them have the following defects: (1) The added amount of the product is 0.1-1.5%; (2) It is a mixture of various materials, and the product function is not good. Clear, but not obvious efficacy; (3) The molecular weight of the peptide is relatively large, generally around 6000, and it is still antigenic, which is not good for animals and can easily cause allergic reactions to antigens; (4) The preparation cost is high or the product cost is high, so it is not suitable for animal breeding use

[0004] The traditional preparation methods of bioactive small peptide feed additives are mainly enzymatic methods, such as the use of plant proteases such as papain and bromelain, or the use of animal proteases such as trypsin and pepsin, but it is easy to produce unacceptable fishy or bitter taste , and the production cost is high; the second is the direct extraction method from raw materials, which has low yield and high cost; the third is the DNA recombinant technology method, because many consumers oppose the use of food products produced by genetically modified organisms, and Restricted by concerns about biosecurity and biocontamination

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