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Process method for preparing high-purity levodopa

A technology of levodopa and process method, which is applied in the field of medicine to achieve the effect of shortening the production cycle, reducing energy consumption and cost, and the method is environmentally friendly

Inactive Publication Date: 2014-03-26
李叶华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problems existing in the existing technological process, the purpose of the present invention is to provide a process for the preparation of high-purity levodopa that improves the transfer rate, reduces energy consumption and is environmentally friendly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Weigh 1Kg of cat beans, break it into coarse particles, add formic acid to adjust it into acidic water with a pH of 4, immerse and extract at room temperature twice, 10 times each time, after filtering the extract, add sodium polyacrylate to make the content 1% , stirred, placed, filtered, and the filtrate was adjusted to a pH value of 3 with hydrochloric acid, and electrodialysis was performed until the liquid outlet no longer reacted with levodopa, and the pH value of the feed liquid was adjusted to 3.5, and placed at a low temperature of 0-4°C Filtrate, put the precipitate in pure water that has been adjusted to a pH value of 1-3 with hydrochloric acid, add 1% vitamin C, heat to dissolve, add 5% activated carbon, stir for 5 minutes, filter while hot, collect the filtrate, 0-4°C Place at low temperature to precipitate crystals, filter, wash the crystals with a small amount of absolute ethanol, and dry below 50°C to obtain the finished product.

Embodiment 2

[0019] Weigh 1Kg of cat beans, break it into coarse particles, add sulfuric acid to adjust it into acidic water with a pH of 3, decoct and extract twice, 8 times each time, after filtering the extract, add chitosan to make the content 0.5% , stir, place, filter, adjust the pH value of the filtrate to 3 with a mixture of boric acid and formic acid, and perform electrodialysis until the liquid outlet no longer reacts with levodopa, adjust the pH value of the feed liquid to 3.5, 0-4 ° C Place at low temperature, filter, place the precipitate in pure water adjusted to a pH of 1-3 with hydrochloric acid, add 1% vitamin C, heat to dissolve, add 5% activated carbon, stir for 5 minutes, filter while hot, and collect the filtrate, 0 Place at -4°C to precipitate crystals, filter, wash the crystals with a small amount of absolute ethanol, and dry below 50°C to obtain the finished product.

Embodiment 3

[0021] Weigh 1Kg of cat beans, crush them into coarse particles, add mixed acid made of hydrochloric acid and sulfuric acid to adjust to acidic water with a pH of 2, extract by percolation, collect 10 times the amount of percolation liquid, add cross-linked sodium polyacrylate to make The content is 1%, stirred, placed, filtered, the filtrate is adjusted to a pH value of 3 with a mixture of boric acid and hydrochloric acid, and electrodialysis is performed until the liquid outlet no longer reacts with levodopa, and the pH value of the feed liquid is adjusted to 3.5 , place at low temperature at 0-4°C, filter, place the precipitate in pure water that has been adjusted to a pH value of 1-3 with hydrochloric acid, add 1% vitamin C, heat to dissolve, add 5% activated carbon, stir for 5 minutes, and filter while hot , collect the filtrate, place it at a low temperature of 0-4°C, precipitate crystals, filter, wash the crystals with a small amount of absolute ethanol, and dry below 50...

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Abstract

The invention discloses a process method for preparing high-purity levodopa. By utilizing chemical characteristics of levodopa, acid water is applied to extract, an impurity removing agent is used for preliminary purifying, and enriching and separating are carried out by virtue of electroosmosis; then, separation is carried out by adopting an isoelectric-point crystallization technology, and a crude crystal is dried to obtain a finished product after being re-crystallized. Process steps are as follows: crushing a mucuna material, adding acid water to extract, adding the impurity removing agent into extracting liquor to remove impurities, filtering, regulating pH value of the liquor to 1-4, entering an electroosmosis device for enriching and separating, regulating the pH value to 3.5, placing at a low temperature of 0 DEG C-4 DEG C, separating out levodopa, regulating acidity of precipitates, adding an antioxidant, placing at the low temperature, separating out crystal, and drying to obtain the finished product. The process method disclosed by the invention adopts the electroosmosis method for enriching and separating the levodopa, so that problems that the levodopa is damaged in an alkaline environment and the like are effectively avoided, and therefore, production period is shortened, energy consumption and cost are lowered; moreover, the method is environmental friendly.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a process for preparing high-purity levodopa. Background technique [0002] Levodopa is a non-protein amino acid with the chemical formula C 9 h 11 NO 4 , the molecular weight is 197.19, the isoelectric point is 3.5, and the melting point is 295°C. It is an important anti-parkinsonian drug, which has a significant effect in the treatment of Parkinson's disease. [0003] There are three sources of levodopa, which are chemical synthesis, microbial fermentation, and plant extraction. According to relevant reports, Ajinomoto Corporation of Japan has the technology to produce levodopa by microbial fermentation. Europe and the United States mainly produce levodopa through chemical synthesis, and my country mainly produces levodopa through plant extraction. [0004] The main problems of the plant extraction method are that the production cycle is long, the process is e...

Claims

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Application Information

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IPC IPC(8): C07C229/36C07C227/40
Inventor 王红莲乐雅武其他发明人请求不公开姓名
Owner 李叶华
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