Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Halcinonide cream

A technology of halcinonide and cream, applied in the field of topical pharmaceutical composition of cinonide, which can solve problems such as hypocalcemia, convulsions, and death

Active Publication Date: 2014-04-09
TIANJIN JINYAO GRP
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, it should be pointed out that patients with lead poisoning who should be treated with edetate calcium and sodium, especially children, may cause serious decrease in blood calcium, convulsions and even death due to misuse of edetate disodium

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Halcinonide cream
  • Halcinonide cream

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1

[0031] Halcinonide 1g, dimethyl sulfoxide 30g, white petrolatum 100g, stearyl alcohol 90g, liquid paraffin 50g,

[0032] Sodium Lauryl Sulfate 50g, Glycerin 50g, Ethyl p-hydroxybenzoate 1g,

[0033] Add edetate disodium 0.1g to 1000g with water for injection,

[0034] Accurately weighed according to the above ratio, the cream preparation process is as follows:

[0035] 1) Mix sodium lauryl sulfate, edetate, ethyl p-hydroxybenzoate, glycerin and distilled water and heat to 70°C;

[0036] 2) The prescribed amount of halcinonide is dissolved in the prescribed amount of dimethyl sulfoxide;

[0037] 3) Heat stearyl alcohol, white petrolatum, and liquid paraffin in the prescribed amount to 80°C, slowly add the mixture obtained in step 1) and stir quickly, then add the halcinonide dimethyl sulfoxide solution in step 3), mix well, and condense into paste. Cream Halcinonide 0.1%

Embodiment 1-2

[0039] According to the recipe and process of Example 1-1, the amount of disodium edetate was changed to 0.25g.

Embodiment 1-3

[0041] According to the recipe and process of Example 1-1, the amount of edetate disodium was changed to 1 g.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Halcinonide cream is provided. The halcinonide cream comprises halcinonide adopted as the active component, solid in oil-phase components, a consistency modifier, a humectant, an emulsifier, an aseptic and water, and is characterized by also comprising edetate calcium disodium.

Description

technical field [0001] The invention relates to a pharmaceutical composition for external use of halcinonide. Background technique [0002] Halcinonide, (halcinonide, CAS: 3093-35-4) adrenal cortex hormone drugs, external use can shrink dermal capillaries, inhibit epidermal cell proliferation or regeneration, inhibit fibroblast regeneration in connective tissue, and stabilize intracellular lysozyme Body membrane, preventing tissue damage caused by the release of lysosomal enzymes, has strong anti-inflammatory and anti-allergic effects. For allergic dermatitis, atopic dermatitis, contact dermatitis, seborrheic dermatitis, eczema, pruritus, psoriasis, neurodermatitis, etc. However, long-term or large-scale application can cause skin atrophy and telangiectasia, acne-like dermatitis, folliculitis, perioral dermatitis, and increased susceptibility to infection. Even can cause allergic contact dermatitis. More importantly, long-term use can also cause pigmentation, that is, ski...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/58A61K47/18A61P17/00
Inventor 陈松赵琳孙亮
Owner TIANJIN JINYAO GRP
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com