Oil injection containing nonsteroidal anti-inflammatory drugs/polyethylene glycol drug-loading particles
A non-steroidal anti-inflammatory, solid polyethylene glycol technology, applied in anti-inflammatory agents, drug combinations, non-central analgesics, etc.
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Embodiment 1
[0022] Embodiment 1, preparation 10% ketoprofen injection
[0023] Preparation composition: Ketoprofen 100g, PEG-10000 50g, H-HPC 25g, IPM added to 1 liter.
[0024] Preparation method: (1) Melt PEG at 60-70°C, add H-HPC and mix well, then add methanol equivalent to 2 times the amount of ketoprofen, after H-HPC dissolves, add ketoprofen, mix well, After being dissolved, methanol is removed under reduced pressure, cooled, solidified, pulverized, and passed through a 40-mesh sieve to obtain drug-loaded particles containing ketoprofen. (2) Disperse the drug-loaded particles in part of the IPM, grind them through a colloid mill until the particle size is less than 50 μm, and further grind them with a sand mill until the particle size is less than 8 μm, add the remaining medium, and use a high-shear homogenizer at about Under the condition of 5000rpm, after repeated homogenization, the ketoprofen injection with the particle size of drug-loaded particles less than 8 μm was prepared...
Embodiment 2
[0025] Embodiment 2, preparation 10% ibuprofen injection
[0026] Preparation composition: ibuprofen 100g, PEG-6000 60g, soybean oil for injection to 1 liter.
[0027] Preparation method: (1) Melt PEG at 60-70°C, add ibuprofen and ethanol equivalent to 3 times the amount of ibuprofen, mix thoroughly to dissolve, cool, dry naturally after solidification, pulverize, pass through 40 mesh sieve to obtain drug-loaded microparticles containing ibuprofen. (2) Disperse the drug-loaded particles in part of soybean oil, grind them through a colloid mill until the particle size is less than 100 μm, and further grind them with a sand mill until the particle size is less than 5 μm, add the remaining medium, and use a high-shear homogenizer to Under the condition of about 5000rpm, after several times of homogenization, the ibuprofen injection with a particle size of less than 5 μm was prepared.
Embodiment 3
[0028] Embodiment 3, preparation 12% indomethacin injection
[0029] Preparation composition: indomethacin 120g, PEG-4000 80g, tea seed oil for injection to 1 liter.
[0030] Preparation method: (1) Melt PEG at 60-70°C, add indomethacin and acetone equivalent to 3 times the amount of indomethacin, reflux to dissolve, remove acetone by distillation under reduced pressure, cool and solidify, crush, pass through 40 mesh Sieve to obtain drug-loaded microparticles containing indomethacin. (2) Disperse the drug-loaded particles in part of the tea seed oil, grind them through a colloid mill until the particle size is less than 100 μm, and further grind them with a sand mill until the particle size is less than 8 μm, add the remaining medium, and use a high-shear homogenizer Under the condition of about 5000rpm, after several times of homogenization, the indomethacin injection with a particle size of less than 8 μm was prepared.
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