Sodium alginate chiral cross-linked membrane and applications thereof

Abstract

The invention discloses a sodium alginate chiral cross-linked membrane and applications thereof. The preparation method of the sodium alginate chiral cross-linked membrane comprises the following steps: weighing a certain amount of sodium alginate, dissolving the sodium alginate into a water solution of acetic acid, carrying out a supersonic treatment to remove the aggregated particle molecules, allowing the system to stand still so as to remove the bubbles; pouring the membrane-forming solution on a clean and smooth glass board at a room temperature, scrapping off the membrane from the glass board with a membrane-scrapping knife, drying for 4 days; putting the dry membrane into an acetone cross-linking agent containing glutaraldehyde and hydrochloric acid to carry out cross-linking reactions; and washing the cross-linked membrane with a large amount of acetone and ultrapure water until the membrane turns neutral so as to obtain the needed chiral cross-linked membrane. The cross-linked membrane is loaded into a normal dialysis device, and then separates D,L-p-hydroxyphenylglycine raceme aqueous solution under the driving of concentration difference, and the enantiomer purity of p-hydroxyphenylglycine in the permeate reaches 60% or more. The raw materials of the membrane are cheap, the purity of the obtained mono-enantiomer is high, and the preparation method of the membrane has the advantages of large throughput, environment-friendliness, low cost, and easiness in continuous operation and massive industrial production.

Description

technical field [0001] The invention belongs to the technical field of separation of chiral polymer membranes, and in particular relates to a sodium alginate chiral crosslinked membrane. At the same time, the invention also relates to the application of the chiral cross-linked membrane in the resolution of D,L-p-hydroxyphenylglycine racemate. Background technique [0002] Chirality is a common phenomenon in nature, and there are a large number of chiral molecules in nature and living organisms. The problem of chirality of drugs arises from the chiral properties of nature to the chirality of compounds. A chiral drug refers to a drug composed of a chiral compound with pharmacological activity, and the molecular structure of the drug and its mirror image cannot be superimposed on each other, and they are drug structural enantiomers in a mirror image relationship. Because the in vivo pharmacokinetic process of the two enantiomers of chiral drugs is different, there are often s...

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Problems solved by technology

[0005] So far, there has been no public report on the chiral crosslinked membrane of sodium alginate and its application in the resolution of D,L-p-hydroxyphenylglycine racemate

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