Preparation method and separation method of surfactant containing amino terminal and diamine group

Abstract

The invention relates to a method for preparing and separating surfactants which have high biological safety and contain amino terminal and diamino. The method comprises the following steps: adding fatty acid solids, 1-(3-dimethylaminopropyl)-3-vinyl carbodiimide solid and 1-hydroxybenzotriazole solids into dichloromethane, and dissolving to obtain a mixed solution; dropwise adding the mixed solution into 1,2-(2-aminoethoxy) ethane, reacting in an ice-salt bath, pouring the obtained reaction solution into saturated salt water, and performing suction filtration on the separated jelly-shaped small molecule gel, thus obtaining a mixture of the surfactants containing amino terminal and diamino; and adding the obtained mixture into a chromatographic column filled with silica gel, eluting by using gradient mixed eluant of dichloromethane and methanol, and separating the mixture of the surfactants containing the amino terminal and diamino, thus respectively obtaining a surfactant containing the amino terminal and a surfactant containing the diamino.

Description

technical field [0001] The invention relates to the preparation and separation of surfactants, in particular to the preparation and separation methods of surfactants containing amino terminal and diamine groups with biological safety. Background technique [0002] Surfactants have the functions and functions of emulsification, dispersion, solubilization, flocculation, and decontamination. These functions have been applied and played an important role in many industrial fields such as detergent, textile, papermaking, leather processing, pigment paint, printing, medicine, food fermentation and petrochemical industry. Therefore, the research and development of the preparation, separation and purification of novel surfactants has important theoretical significance and application value. Among them, surfactants containing amino terminal and diamine groups have received extensive attention from researchers at home and abroad (Aleksandar Todorovic, Jerry Ryan Holder, Rayna M. Bauz...

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Problems solved by technology

With the development of medical science and technology and the enhancement of human awareness of environmental protection, this type of surfactant has a broad application prospect. However, due to the cumbersome and long-term preparation process of this type of surfactant, the separation process is difficult, and the equipment and equipment required for separation It is more expensive, the separation operation is complicated, and the exchange resin used in the conventional separation inevitably occurs between the exchange resin and the product, resulting in product loss and low separation efficiency. (Fu Haiyan, Zeng Guangming, Yuan Xingzhong, Huang Guo, Shi Jingang, Zhong Hua. Journal of Biology, 2003, Volume 20, Issue 6, Pages 1-4.) and the literature "Application and Development Trend of Biosurfactants" ( Yang Shidi. "Application and Development Trend of Biosurfactants", Today's Science and Technology, 2002, Volume 9, 40-41.) and other articles have summarized these difficulties as the main problems hindering the wide application of this type of surfactants. It can be seen that , Reducing the difficulty of preparation, separation and purification is the core content of this type of surfactant research field. The present invention is just to solve the above problems, thereby providing a simple, economical and efficient preparation, separation and purification with biological safety The method of the surfactant containing amino terminal and diamine group

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