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patch

A technology of patch and methyl, which is applied in the field of patch, and can solve the problems such as the storage stability of rivastigmine that has not been disclosed

Active Publication Date: 2017-06-20
TOYO INK SC HOLD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although Patent Document 4 discusses improving the adhesiveness of the patch, it does not disclose the storage stability of rivastigmine

Method used

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Embodiment

[0085] Hereinafter, although an Example demonstrates this invention concretely, this invention is not limited to these Examples.

[0086] (Preparation of Acrylic Adhesive A)

[0087] Acrylic Adhesive A was prepared as follows. The reaction liquid is supplied to a polymerization reactor of 40 liters, and the reaction liquid is composed of 50 parts by weight of ethyl acetate and 13 parts by weight of lauryl methacrylate, 78 parts by weight of 2-ethylhexyl methacrylate and 2 parts by weight of acrylic acid. - A monomer composition of 9 parts by weight of ethylhexyl ester. Then, the inside of the polymerization reactor was adjusted to a nitrogen atmosphere of 80°C. Then, a polymerization initiator solution obtained by dissolving 0.5 parts by weight of benzoyl peroxide in 50 parts by weight of cyclohexane was added to the above-mentioned reaction solution over 24 hours, and at the same time, the above-mentioned monomers were subjected to a copolymerization reaction. After the po...

Embodiment (1～12

[0093] Mix rivastigmine, acrylic binder solution A, acrylic binder solution B, stearyl alcohol (manufactured by Advanced Alcohol Industry Co., Ltd.), and light silica (manufactured by Japan Aerosil Co., Ltd., A200) as a solvent Ethyl acetate was added so that the concentration of the solid content became 25% by weight, and then mixed until uniform to prepare an adhesive layer solution.

[0094] Then, a release sheet was prepared which had been subjected to a release treatment by coating polysiloxane on one side of a release base material having a thickness of 38 μm and formed of a polyethylene terephthalate film. The adhesive layer solution was applied on the release-treated surface of the release sheet, and dried at 80° C. for 30 minutes, thereby producing a film having the thickness shown in Table 1 on the release-treated surface of the release sheet. A laminate of adhesive layers. It should be noted that the content of each component in the adhesive layer is as shown in Ta...

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Abstract

The present invention relates to a patch with excellent storage stability of rivastigmine, which can increase the skin permeability of rivastigmine to obtain the transdermal absorption required for the treatment of Alzheimer's disease. degree of quantity. The present invention provides a patch, which includes a support and an adhesive layer. The adhesive layer is laminated and integrated on one side of the support, and contains an alkyl (meth)acrylate copolymer and Rivas. It should be noted that the (meth)acrylic acid alkyl ester copolymer does not contain an acrylic monomer component having a carboxyl group.

Description

technical field [0001] The present invention relates to a patch having excellent storage stability of rivastigmine, wherein the skin permeability of rivastigmine of the patch can be improved so that transdermal absorption required for the treatment of Alzheimer's disease can be obtained the degree of quantity. Background technique [0002] In recent years, along with the increase of elderly people, the number of patients with dementia due to Alzheimer's disease is also increasing. As drugs for improving dementia in Alzheimer's disease, anticholinesterase agents such as donepezil hydrochloride and Levans' minartrate have been developed. These preparations are clinically made into oral preparations such as tablets and liquids to be administered to dementia patients. [0003] However, for dementia patients, along with the development of dementia, poor compliance with medication and decreased swallowing function may occur. Therefore, in many cases, it is difficult for patients...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/325A61K47/32A61P25/28
CPCA61K9/7061A61K31/27A61P25/28
Inventor 荐田俊一
Owner TOYO INK SC HOLD CO LTD
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