Emamectin benzoate microsphere and preparation method thereof

A technology of emamectin and benzoate, which is applied in the field of emamectin benzoate microspheres and its preparation, and can solve the problems of unstable efficacy, short validity period, and waste of resources in the field

Inactive Publication Date: 2014-05-21
INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing preparation has following shortcoming: emulsifiable concentrate preparation contains a large amount of volatile organic solvents, discharges in the environment, not only pollutes ecological environment, and causes resource waste; It is easy to photolysis and lose efficacy, and the persistence period is short; conventional pesticide preparations are quick-acting, and the validity period is short during the growth period of crops, requiring multiple application, which reduces the utilization rate of pesticides and increases the amount of pesticide application and labor costs.
[0006] Emamectin benzoate is unstable to light, severely degraded by ultraviolet light, and the field efficacy is unstable

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 : 13.7% emamectin benzoate microspheres (D 50 9.2μm) preparation

[0021] Prepared by emulsification-solvent evaporation method. Weigh 1.2g of polylactic acid in 20mL of dichloromethane and place on a magnetic stirrer to stir. After the polylactic acid is completely dissolved, add 0.3g of emamectin benzoate and continue to stir to make it completely dissolve. oily phase. Take 160mL of distilled water, add 0.8g of gelatin and dissolve at 40°C as the water phase. Adjust the temperature of the magnetic stirrer to 30°C and the speed to about 1000r / min, add 1d of silicone defoamer, slowly add the oil phase to the water phase, and emulsify at 1000r / min for 3 hours to form a homogeneous emulsion ( O / W). Then the temperature of the magnetic stirrer was raised to 40° C., the rotation speed was adjusted to 500 r / min, and the stirring was continued for 2 h to allow the dichloromethane to fully volatilize. Suction filtration under reduced pressure, washing with dist...

Embodiment 2

[0023] Example 2 : 13% emamectin benzoate microspheres (D 50 23.4μm) preparation

[0024] The weighed polylactic acid was 1.8g, the gelatin consumption was 2.4g, and other preparation methods were the same as in Example 1. The prepared microspheres had a drug loading capacity of 13%, an encapsulation efficiency of 88.3%, a volume median diameter of 23.4 μm, and a span of 0.75. It can be seen that changing the amount of polylactic acid and gelatin can prepare microspheres with different particle sizes to meet the needs of different durations of soil treatment.

Embodiment 3

[0025] Example 3 : Preparation of 20.6% emamectin benzoate microspheres

[0026] The polylactic acid that takes by weighing is 1.6g, emamectin benzoate is 0.8g, and gelatin is 2.4g, and other preparation methods are with embodiment 1. The prepared microspheres had a drug loading of 20.6%, an encapsulation efficiency of 79.4%, a volume median diameter of 80.4 μm, and a span of 1.00.

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PUM

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Abstract

The invention discloses an emamectin benzoate microsphere and a preparation method thereof. The emamectin benzoate microsphere is prepared by utilizing an emulsification-volatilization method. According to the emulsification-volatilization method, solid spherical microspheres are prepared by taking polylactic acid as a carrier and taking gelatin as a dispersant, wherein the microspheres are monodispersed fine powder, and the particle size distribution of the microspheres is uniform. According to the emamectin benzoate microsphere, active ingredients are slowly released, the stability of emamectin benzoate is improved, a persistent effect is long, the work efficiency is high, and a lasting period can reach 3-6 months after the microsphere is applied once. The emamectin benzoate microsphere disclosed by the invention is suitable for being mixed with soil to be applied and can be widely used for treating soil insects and root-knot nematode of various crops.

Description

technical field [0001] The invention relates to emamectin benzoate microspheres and a preparation method thereof, belonging to the field of pesticide preparations. Background technique [0002] Emamectin benzoate is a high-efficiency, broad-spectrum, and pollution-free biological source insecticide, developed by Merck in the United States. It is the product of structural modification of abamectin, and its efficacy against most Lepidoptera larvae is higher than that of abamectin, especially against the vegetable beet armyworm, which is 2 orders of magnitude higher than that of abamectin. Sexual diamondback moth and cotton bollworm special effects, but the toxicity is much lower than abamectin. [0003] The existing preparations of emamectin benzoate mainly include conventional dosage forms such as emulsifiable concentrate, microemulsion, water-dispersible granule, and effervescent tablet. Existing preparation has following shortcoming: emulsifiable concentrate preparation c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N25/10A01N43/90A01P7/04
Inventor 陈福良朱新妍尹明明
Owner INST OF PLANT PROTECTION CHINESE ACAD OF AGRI SCI
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