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Medicinal composition for treating oral fungal infection, preparation method and application thereof

A fungal infection and composition technology, which is applied in the field of pharmaceutical compositions for the treatment of fungal infections, can solve the problems of high price and difficulty in widespread use, and achieve the effects of less side effects, good therapeutic effect, and less irritation

Inactive Publication Date: 2014-11-05
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The above-mentioned conventional antifungal drugs have achieved a certain therapeutic effect clinically, but there are also many side effects, which can cause gastrointestinal dysfunction, leukocytes, thrombocytopenia, and elevated transaminases. Itraconazole and fluconazole, a fluorinated triazole drug, have overcome the problem of side effects, but they are relatively expensive and difficult to be widely used on a large scale

Method used

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  • Medicinal composition for treating oral fungal infection, preparation method and application thereof
  • Medicinal composition for treating oral fungal infection, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Weigh 10g of raw materials Poria cocos, 5g of dandelion, 5g of atractylodes, 5g of atractylodes, 5g of Agastache 5g, 5g of Pinellia ternata, 3g of tangerine peel, 3g of Qianghuo, 3g of Ligusticum chuanxiong, 1g of ginger, 1g of ginseng, 1g of honeycomb, adding 50g of auxiliary starch for granulation, hard Magnesium fatty acid 5g, dextrin 25g, and microcrystalline cellulose 25g are uniformly prepared into granules and compressed to obtain tablets.

Embodiment 2

[0024] Weigh 15g of raw materials Poria cocos, 8g dandelion, 8g atractylodes, 8g of atractylodes, 8g of Agastache 8g, 8g of Pinellia ternata, 5g of tangerine peel, 5g of Qianghuo, 5g of Ligusticum chuanxiong, 2g of ginger, 2g of ginseng, 2g of honeycomb, adding 70g of auxiliary starch granules, hard Magnesium fatty acid 8g, dextrin 50g, and microcrystalline cellulose 50g are uniformly prepared into granules and compressed to obtain tablets.

Embodiment 3

[0026] Weigh 20g of raw materials Poria cocos, 10g dandelion, 10g atractylodes, 10g atractylodes, 10g Agastache 10g, Pinellia 10g, 8g tangerine peel, 8g Qianghuo, 8g Ligusticum chuanxiong, 3g ginger, 3g ginseng, 3g honeycomb, add 90g of auxiliary starch granules, hard 12 g of magnesium fatty acid, 60 g of dextrin, and 60 g of microcrystalline cellulose are uniformly prepared into granules and compressed to obtain tablets.

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a medicinal composition for treating oral fungal infection. The medicinal composition comprises the following raw materials in parts by weight: 10-45 parts of poria, 5-40 parts of dandelion, 5-40 parts of bighead atractylodes rhizome, 5-40 parts of rhizoma atractylodis, 5-40 parts of musk, 5-40 parts of processed pinellia tuber, 3-30 parts of dried tangerine peel, 3-30 parts of notopterygium root, 3-30 parts of ligusticum wallichii, 1-10 parts of raw ginger, 1-10 parts of ginseng and 1-20 parts of nidus vespae. The invention also provides a preparation method and particular application of the medicinal composition. Pharmacodynamic tests prove that the medicinal composition has strong antibacterial activity to candida albicans, candida albicans, aspergillus, mucor, cryptococcus and other fungi, and has a good treatment effect to patients infected with oral fungi. The medicinal composition has the advantages of good curative effect, small irritation, small side effect and low administration cost, is suitable for large-scale popularization and use, and has a good medical prospect.

Description

Technical field [0001] The invention relates to a pharmaceutical composition for treating fungal infections, in particular to a pharmaceutical composition for treating and relieving oral fungal infections, and a preparation method and application thereof, belonging to the technical field of traditional Chinese medicine. Background technique [0002] The most common pathogens of oral fungal infections are Candida spp. Among them, Candida albicans and Candida tropicalis are the most pathogenic, and they are also the most common pathogens of Candida spp. Oral fungal infections can occur in any part of the oral cavity, such as the lips, tongue, soft palate, hard palate, tonsils, palate, gums, and pharynx. It often manifests as local inflammation, swelling, pain, discomfort, ulcers and erythema, abnormal taste and oral mucosal hyperplasia. Fungal diseases are highly contagious and can be widely prevalent. In recent years, with the application of antibiotics and immunosuppressive drug...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P1/02A61P31/10A61K35/64
Inventor 金钊左渝陵周琳悦赵娟
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE