Hemofiltration solution and preparation method thereof

A technology of hemofiltration and replacement fluid, applied in the fields of blood diseases, pharmaceutical formulations, extracellular fluid diseases, etc., can solve the problems of cumbersome operation without calcium replacement fluid, lack of restrictions on the widespread development of citrate anticoagulation, etc., to reduce death. rate, avoid hypophosphatemia and the loss of a large number of micronutrients, the effect of broad application prospects

Active Publication Date: 2014-05-28
CHENGDU QINGSHAN LIKANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the cumbersome operation and the lack of calcium-free replacement fluid limit the widespread use of citrate anticoagulation in clinical practice.

Method used

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  • Hemofiltration solution and preparation method thereof
  • Hemofiltration solution and preparation method thereof
  • Hemofiltration solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Embodiment 1 Preparation of blood replacement fluid of the present invention

[0041] Take anhydrous glucose 2.880kg, sodium chloride 11.040kg, magnesium chloride hexahydrate 0.305kg, calcium chloride hexahydrate 0.613kg, sodium dihydrogen phosphate dihydrate 0.312kg, sodium citrate dihydrate 7.056kg, vitamin C 35.200g, Folic acid 0.035g, vitamin B6 0.034g, sodium selenite 0.346g, dissolve in appropriate amount of water for injection, add appropriate amount of activated carbon and stir, filter through a 0.45μm titanium rod, add water for injection to a total volume of 2000 liters, filter through a 0.22μm terminal filter , filled in the infusion bag of non-PVC composite film soft bag, sealed, and sterilized at 115 degrees Celsius for 30 minutes.

[0042] Corresponding ion concentration:

[0043] Sodium ion (mmol / L) 130 Magnesium ion (mmol / L) 0.75 Potassium ion (mmol / L) 0 Calcium ion (mmol / L) 1.4 Chloride ion (mmol / L) 100 Dihydrogen...

Embodiment 2

[0044] Embodiment 2 Preparation of blood replacement fluid of the present invention

[0045] Take anhydrous glucose 1.800kg, sodium chloride 10.432kg, magnesium chloride hexahydrate 0.203kg, calcium chloride hexahydrate 0.438kg, potassium chloride 0.298kg, sodium dihydrogen phosphate dihydrate 0.208kg, sodium citrate dihydrate 9.408kg , sodium selenite 0.346g, dissolved in an appropriate amount of water for injection, added an appropriate amount of activated carbon and stirred, filtered through a 0.45μm titanium rod, added water for injection to a total volume of 2000 liters, filtered through a 0.22μm terminal filter, and filled in a non-PVC composite membrane Put it in the infusion bag of the soft bag, seal it, and sterilize it at 115 degrees Celsius for 30 minutes.

[0046] Corresponding ion concentration:

[0047] Sodium ion (mmol / L) 125 Magnesium ion (mmol / L) 0.75 Calcium ion (mmol / L) 1.0 Potassium ion (mmol / L) 2 Chloride ion (mmol / L) 92....

Embodiment 3

[0048] Embodiment 3 Preparation of hemofiltration replacement fluid of the present invention

[0049] Anhydrous glucose 4.320kg, sodium chloride 12.740kg, magnesium chloride hexahydrate 0.203kg, calcium chloride hexahydrate 0.745kg, potassium chloride 0.373kg, sodium dihydrogen phosphate dihydrate 0.468kg, sodium citrate dihydrate 4.704kg, Dissolve 52.800g of vitamin C, 0.070g of folic acid, and 0.027g of vitamin B in an appropriate amount of water for injection, add an appropriate amount of activated carbon and stir, filter through a 0.45μm titanium rod, add water for injection to a total volume of 2000 liters, filter through a 0.22μm terminal filter, and fill Put it in the infusion bag of non-PVC composite film soft bag, seal it, and sterilize it at 115 degrees Celsius for 30 minutes.

[0050] Corresponding ion concentration:

[0051] Sodium ion (mmol / L) 145 Magnesium ion (mmol / L) 0.5 Potassium ion (mmol / L) 2.5 Calcium ion (mmol / L) 1.7 Chlor...

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Abstract

The invention discloses a hemofiltration solution and a preparation method thereof. The hemofiltration solution contains phosphorus, a variety of trace elements and citrate radical ions besides water, sodium, potassium, magnesium, chlorine and glucose, can prevent hypophosphatemia and loss of considerable micronutrient elements, has anticoagulation action, is capable of effectively reducing mortality of patients and simple to operate, hardly poses pollution, provides a better option for clinical practice and has wide application prospects.

Description

technical field [0001] The invention relates to a hemofiltration replacement fluid and a preparation method thereof. Background technique [0002] Continuous renal replacement therapy (CRRT) is a new type of blood purification technology, which has many advantages such as stable hemodynamics, slow and continuous removal of solutes and water, removal of inflammatory mediators, and regulation of immunity. AKI) is the most important treatment modality. In addition, CRRT is also widely used in the treatment of acute severe pancreatitis, crush syndrome, acute poisoning and other critical illnesses. [0003] Replacement fluid is an important part of CRRT treatment. Each adult patient needs to use a large amount of replacement fluid during CRRT treatment, about 30-60L / day. The treatment of CRRT is mainly based on hemofiltration, and the replacement fluid is directly injected into the blood into the body. Therefore, strict requirements are imposed on the endotoxin and bacterial le...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/42A61P7/08A61K31/194A61K31/7004A61K33/00A61K33/06A61K33/14A61K31/519A61K31/4415A61K31/375
Inventor 张凌付平陈志文岳荣铮陶冶
Owner CHENGDU QINGSHAN LIKANG PHARMA CO LTD
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