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Production method of starch empty capsule

A production method and technology of hollow capsules, applied in capsule delivery, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve the problems of unqualified products and achieve low cost, simple process and convenient operation

Active Publication Date: 2014-06-04
QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In addition, in the process of capsule molding, various process parameters and conditions are very important, especially the dipping temperature, rubber plate temperature and capsule drying temperature will have a great impact on the product quality of the capsule. If these parameters are slightly changed, qualified products may not be obtained

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 9～16

[0075] In following embodiment 9~16:

[0076] 1. The equipment used is a complete set of semi-automatic production line equipment of Zhejiang Tianlong Capsule Co., Ltd.

[0077] 2. Capsule product detection method

[0078] According to the "Pharmacopoeia of the People's Republic of China" 2010 Edition Part II about the capsule disintegration time limit, water content and other indicators and the detection method stipulated in the "Empty Capsule Industry Standard".

[0079] 3. The "qualified" products mentioned below are those whose quality fully meets the requirements of the Pharmacopoeia (that is, the thickness of the capsule shell is 9-11 silk, the thickness of the capsule cap is 8-10 silk, the disintegration time in the body is within 10 minutes, and the hollow The loss on drying of the capsules is in the range of 5-12%) capsules.

Embodiment 1

[0080] The preparation of embodiment 1 starch glue (one)

[0081] In a 180L reactor, add 100L distilled water, 1.2 parts of sorbitol, and 0.8 parts of carrageenan, heat it to 40°C and stir for 30 minutes to completely dissolve it, then raise the temperature to 70°C (at this temperature, the carrageenan dissolves quickly and fully) Stir mechanically at this temperature for 30 minutes to fully dissolve, add 8 parts of cornstarch, stir at a speed of 400r / min, slowly raise the temperature to 90°C until stirring for 80 minutes, lower the temperature to 65°C, and weigh 0.06 parts of α-amylase Add it into the glue, keep the temperature and continue to stir at 400r / min for 45 minutes, quickly add 460mL1mol / L sodium hydroxide, and increase the temperature to 85°C (experiments found that the air bubbles are more clean at high temperatures), Stir for 10 minutes to inactivate the enzyme, then quickly add 460uL of 1mol / L dilute hydrochloric acid to neutralize NaOH, add 0.2 parts of hydroxy...

Embodiment 2

[0083] The preparation of embodiment 2 starch glue (two)

[0084] In a 180L reaction kettle, add 100L distilled water, 1.2 parts of sorbitol, 0.6 gellan gum + 0.2 parts of carrageenan, heat to 50°C, heat and stir for 30 minutes to dissolve completely, raise the temperature to 70°C, and mechanically Stir for 30 minutes to fully dissolve, add 10 parts of amylose, stir at a speed of 400r / min, slowly raise the temperature to 100°C until stirring for 80 minutes, then lower the temperature to 65°C, weigh 0.06 parts of α-amylase and add it to the glue During the process, keep the temperature and continue to stir at 400r / min for 45min, quickly add 460mL of 1mol / L sodium hydroxide, and increase the temperature to 85°C (experiments have found that the air bubbles are discharged more cleanly at high temperatures), and stir for 10min to make the enzyme Inactivate, then quickly add 460mL of 1mol / L dilute hydrochloric acid to neutralize NaOH, add 0.2 parts of hydroxypropyl cellulose, stir u...

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Abstract

The invention relates to a production method of a starch empty capsule. The raw material used is a low viscosity starch gel liquid. A preparation method of the low viscosity starch gel liquid comprises the following steps: mixing gel, a plasticizer and water; stirring and dissolving; then, adding starch or modified starch; and heating to gelatinize the starch. The preparation method is characterized by further comprising the step of adding amylase for enzyme reaction to obtain the gel liquid with the viscosity of 1000-7000cps. Production conditions such as dipping temperature, temperature of a gel disc and temperature of a drying tunnel which are strictly controlled are obtained when the hollow capsule is prepared by using the low viscosity starch gel liquid by means of repeatedly researching and testing the technological parameters of each step in production of the hollow capsule. By taking the starch as the raw material, a hollow plant capsule product which satisfies the requirements of pharmacopeia can be produced. The production method disclosed by the invention is simple in process and convenient to operate. Existing capsule production equipment can be directly utilized, so that the production method is suitable for industrialized production.

Description

technical field [0001] The invention relates to a preparation process of non-gelatin capsules, in particular to a production method of starch hollow capsules. Background technique [0002] Starch capsule product is a new type of non-gelatin capsule, which has the advantages of being safe, non-toxic, cheap and easy to obtain, and biodegradable. [0003] The production method of the traditional gelatin hard capsule is to add glue with a certain viscosity and temperature into the machine dipping plate, after dipping the oiled mold, transfer it to the air duct for drying, demoulding, cutting, fitting and other processes. . However, the prior art method utilizes a variety of starch raw materials to trial-produce capsules with poor uniformity, and always has the disadvantages of high brittleness and low strength. [0004] Those skilled in the art know that if the existing gelatin process is used to produce capsules, it is difficult to obtain qualified starch capsules by directly...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K9/48
Inventor 牟新东姜义军孙载明
Owner QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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