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Monodisperse polarity isomerism Janus microsphere with controllable grain diameter and morphology, preparation method of microsphere and microfluid control device used in method

A polar heterogeneous, monodisperse technology, applied in the direction of microsphere preparation, chemical instruments and methods, microcapsule preparation, etc., can solve the problems of complex process, high cost, low yield, etc., and achieve good surface morphology and uniform particle size , The effect of simple control of microsphere shape and particle size

Inactive Publication Date: 2014-06-11
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These synthesis methods have their own advantages and disadvantages: the microfluidic synthesis method is the only method that can prepare Janus particles by one-time molding, the process is simple, and the yield is high; the topological surface selective modification method has various methods, the preparation process is simple, but the yield is high. Low; template-directed self-assembly process is complicated and the cost is too high
The existing methods are still unable to achieve the control of the monodispersity of Janus particles and the precise regulation of size and shape.

Method used

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  • Monodisperse polarity isomerism Janus microsphere with controllable grain diameter and morphology, preparation method of microsphere and microfluid control device used in method
  • Monodisperse polarity isomerism Janus microsphere with controllable grain diameter and morphology, preparation method of microsphere and microfluid control device used in method
  • Monodisperse polarity isomerism Janus microsphere with controllable grain diameter and morphology, preparation method of microsphere and microfluid control device used in method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Mix 19.2g TPGDA and 0.8g HCPK, dissolve with magnetic stirring, and make a non-polar dispersed phase solution.

[0056] Take six groups of 1g acrylamide, 0.15g bisacrylamide, and 0.05g ammonium persulfate and mix them, then add 0.006g, 0.01g, 0.015g, 0.02g, 0.06g, 0.1g of dodecane to the six groups of mixtures Sodium phenyl sulfonate (SDBS), then add water to 20g, and magnetically stir to dissolve, and make six sets of polar dispersed phase solutions, numbered a, b, c, d, e respectively.

[0057] Put the polar dispersed phase solution and nonpolar dispersed phase solution of group a above into 1mL polar dispersed phase syringe and nonpolar dispersed phase syringe respectively, and then take simethicone as continuous phase solution and fill it into 20mL continuous Phase syringes, install the three syringes on the corresponding syringe pumps, control the flow rate of the polar dispersion solution and the non-polar dispersion phase solution to 2 μL min -1 , the flow rate ...

Embodiment 2

[0061] Mix 19.2g TPGDA and 0.8g HCPK, dissolve with magnetic stirring, and make a non-polar dispersed phase solution.

[0062] Take 1g of acrylamide, 0.15g of bisacrylamide, 0.05g of ammonium persulfate, and 0.01g of sodium dodecylbenzenesulfonate (SDBS), add water to 20g, magnetically stir to dissolve, and make a polar dispersed phase solution.

[0063] Put the above polar dispersed phase solution and non-polar dispersed phase solution into 1mL polar dispersed phase syringe and nonpolar dispersed phase syringe respectively, then take simethicone as continuous phase solution and load it into 20mL continuous phase syringe , install the three syringes on the corresponding syringe pumps respectively, and connect the microfluidic controller. Set the flow rate of the polar dispersed phase solution to 1 μL min -1 , the flow rate of the non-polar dispersed phase solution is 3 μL min -1 , the flow rate of the continuous phase solution is 100 μL min -1 , The size of polar dispersed ...

Embodiment 3

[0068] Mix 19.2g TPGDA and 0.8g HCPK, dissolve with magnetic stirring, and make a non-polar dispersed phase solution.

[0069] Take 1g of acrylamide, 0.15g of bisacrylamide, 0.05g of ammonium persulfate, and 0.06g of sodium dodecylbenzenesulfonate (SDBS), add water to 20g, magnetically stir to dissolve, and make a polar dispersed phase solution.

[0070] Put the above-mentioned polar dispersed phase solution and non-polar dispersed phase solution into 1mL polar dispersed phase syringe 2-2 and non-polar dispersed phase syringe 2-3 respectively, and then take simethicone as continuous phase solution Inject the 20mL continuous phase syringe 2-1, and install the three syringes on the corresponding syringe pumps respectively. Set the flow rate of the polar dispersed phase solution to 2 μL min -1 , the flow rate of the non-polar dispersed phase solution is 2 μL min -1 , the flow rate of the continuous phase solution is 50 μL min -1 , The size of the polar dispersed phase capillar...

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Abstract

The invention discloses a monodisperse polarity isomerism Janus microsphere with the controllable grain diameter and morphology, a preparation method of the microsphere, and a microfluid control device used in the method. The preparation method is characterized by comprising the following steps: preparing a polar dispersion phase solution, a non-polar dispersion phase solutions and a continuous phase solution; under the shearing action of the continuous phase solution, contacting the two dispersion phase solutions to form Janus liquid drops with different hemispherical polarities; adjusting and controlling the morphologies and the sizes of the Janus liquid drops by adjusting and controlling the concentration of a surface active agent in the polar dispersion phase solution, the flow ratio of the polar dispersion phase solution and the non-polar dispersion phase solution, and the flow rates of the polar dispersion phase solution, the non-polar dispersion phase solution and the continuous phase solution; curing the liquid drops so as to obtain the monodisperse polarity isomerism Janus microspheres, wherein the size range is 200-500 microns, and the coefficient of dispersion CV is smaller than 5%. The microfluid control device is simple in structure and easy and convenient to assemble and disassemble, so that the polarity isomerism Janus microspheres with the different sizes and morphologies can be conveniently obtained.

Description

technical field [0001] The invention relates to the field of preparation of polar anisotropic Janus microspheres, in particular to a monodisperse polar anisotropic Janus microspheres with controllable particle size and shape, a preparation method and a device thereof. Background technique [0002] Janus particles refer to asymmetric particles that contain two different chemical compositions or have different properties on the surface, which are manifested in the differences in mechanical properties, magnetic properties, optical properties, electrical properties, and surface hydrophilic and hydrophobic properties (polarity) on both sides of the microspheres. . Due to the asymmetric nature of the two sides of the Janus particle, it has an additional directional force. With the help of this directional force, the spatial assembly of the particles can be realized. For example, Janus microparticles with opposite polarities have hydrophilic parts and hydrophobic parts on both sid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/02B01L3/00
Inventor 常振旗吴林军
Owner UNIV OF SCI & TECH OF CHINA
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