L-tryptophan double-effect continuous evaporation deamination process

A tryptophan deamination liquid and tryptophan technology are applied in the L-tryptophan double-effect continuous evaporation deamination process and the evaporation concentration deamination process of L-tryptophan fermentation filtrate, which can solve the problem of increasing Production costs, large steam consumption and other issues, to achieve energy saving, good deamination effect, high concentration effect

Active Publication Date: 2016-04-13
无锡荣丰生物工程有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This kind of process consumes a lot of steam, which increases the production cost. At the same time, it runs counter to the current energy saving, emission reduction, and environmental protection. There must be a new process to replace the original single deamination process.

Method used

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  • L-tryptophan double-effect continuous evaporation deamination process

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Effect test

Embodiment 1

[0020] Embodiment 1: a kind of L-tryptophan double-effect continuous evaporation deamination process, comprising the following process steps:

[0021] (1) After the L-tryptophan fermentation broth is sterilized, it enters the metal microfiltration membrane or ceramic membrane for microfiltration, ion exchange and other processes to remove impurities such as bacteria, protein and macromolecular pigments, and obtain clear L-tryptophan Amino acid filtrate, the mass percent concentration of L-tryptophan in the L-tryptophan filtrate is 2%, the temperature is 45°C, the free ammonia content is 1.0-1.2%, and the pH value is 9.5; the L - The tryptophan filtrate is sent into the feed buffer tank;

[0022] (2) Send the L-tryptophan filtrate in the feed buffer tank to the deamination tower to obtain the L-tryptophan deamination solution, the quality of L-tryptophan in the L-tryptophan deamination solution The percentage concentration is 2%, the temperature is 50°C, the free ammonia conte...

Embodiment 2

[0027] Embodiment two: a kind of L-tryptophan double-effect continuous evaporation deamination process, comprising the following process steps:

[0028] (1) After the L-tryptophan fermentation broth is sterilized, it enters the metal microfiltration membrane or ceramic membrane for microfiltration, ion exchange and other processes to remove impurities such as bacteria, protein and macromolecular pigments, and obtain clear L-tryptophan Amino acid filtrate, the mass percent concentration of L-tryptophan in the L-tryptophan filtrate is 2%, the temperature is 45°C, the free ammonia content is 1.0-1.2%, and the pH value is 9.5; the L - The tryptophan filtrate is sent into the feed buffer tank;

[0029] (2) Send the L-tryptophan filtrate in the feed buffer tank to the deamination tower to obtain the L-tryptophan deamination solution, the quality of L-tryptophan in the L-tryptophan deamination solution The percentage concentration is 1.9%, the temperature is 56°C, the free ammonia c...

Embodiment 3

[0034] Embodiment three: a kind of L-tryptophan double-effect continuous evaporation deamination process, comprising the following process steps:

[0035] (1) After the L-tryptophan fermentation broth is sterilized, it enters the metal microfiltration membrane or ceramic membrane for microfiltration, ion exchange and other processes to remove impurities such as bacteria, protein and macromolecular pigments, and obtain clear L-tryptophan Amino acid filtrate, the mass percent concentration of L-tryptophan in the L-tryptophan filtrate is 2%, the temperature is 45°C, the free ammonia content is 1.0-1.2%, and the pH value is 9.5; the L - The tryptophan filtrate is sent into the feed buffer tank;

[0036](2) Send the L-tryptophan filtrate in the feed buffer tank to the deamination tower to obtain the L-tryptophan deamination solution, the quality of L-tryptophan in the L-tryptophan deamination solution The percentage concentration is 1.8%, the temperature is 58°C, the free ammonia ...

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Abstract

The invention relates to a double-effect continuous evaporating deaminizing process of L-tryptophan. The process is characterized by comprising the following steps of: (1) conveying L-tryptophan filtration liquid into a feeding buffering tank, wherein the L-tryptophan filtration liquid is prepared by separating L-tryptophan fermentation liquid with a membrane; (2) feeding the L-tryptophan filtration liquid from the feeding buffering tank to a deaminizing tower for deaminzing; (3) evaporating and concentrating the L-tryptophan deaminizing liquid (treated by the deaminizing tower) in a double-effect evaporator; (4) evaporating and concentrating the L-tryptophan primary concentrate (treated by the double-effect evaporator) in an one-effect evaporator; and (5) feeding the L-tryptophan secondary concentrate treated by the one-effect evaporator into a discharging buffering tank; and heating with steam in the process of evaporating and deaminizing L-tryptophan filtration liquid, wherein the steam flows through the primary evaporator, the secondary evaporator, the deaminizing tower and a condenser in sequence. According to the process, the secondary steam is used as a heat source for deaminizing, thus the energy consumption is saved, good deaminizing effect is brought, and the ammonia water recovery concentration is high and reaches 5 to 8%.

Description

technical field [0001] The invention relates to an L-tryptophan double-effect continuous evaporation deamination process, in particular to an evaporation concentration deamination process of L-tryptophan fermentation filtrate, which belongs to the technical field of biological fermentation. Background technique [0002] The chemical name of L-tryptophan is L-aminoindolepropionic acid, and the molecular formula is C 11 h 12 N 2 o 3 , the molecular weight is 204.23. L-tryptophan is an essential amino acid for humans and animals. It participates in the body's protein synthesis and metabolic network regulation. It exists widely in nature, but it is rarely synthesized in the body and needs to be taken from the outside. [0003] The preparation methods of L-tryptophan mainly include microbial method, chemical synthesis method and protein hydrolysis method. Microbiological methods are now dominant. This method can be roughly divided into direct fermentation method, microbial ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D209/20
CPCC07D209/20
Inventor 杨士鑫
Owner 无锡荣丰生物工程有限公司
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