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Fuyankang granule and its production method

A production method and technology of Fuyankang are applied in the field of Fuyankang granules and their production to achieve the effects of improving extraction rate, high speed and improving product qualification rate

Active Publication Date: 2016-05-04
兰州和盛堂制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the problems existing in the prior art in the preparation process of the above-mentioned Fuyankang granules, the inventor finally invented a production method of Fuyankang granules through a large amount of scientific practice, which can effectively overcome the problems in the prior art. Defects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Preparation of Fuyankang extract: Red peony root, Smilax glabra, Sanleng (in vinegar), Chuan neem (fried), Corydalis (Vinegar), Gorgon (stir-fried), Angelica, Sophora flavescens, Cyperus rotundus (Vinegar broiled), Phellodendron amurense and Salvia miltiorrhiza, after the standard ingredients of Fuyankang tablets in the Pharmacopoeia of the People’s Republic of China, put the medicinal materials in the extraction tank, and add 5 times the total mass of the medicinal materials in the enzymatic hydrolysis solution. Enzymatic hydrolysis at 37°C for 1.5 hours.

[0025] Before putting the medicinal materials into the extraction tank, the medicinal materials are crushed. The enzymolysis solution is prepared by dissolving 3 grams of a composite enzyme preparation with an enzyme activity of 24000 units in 500 ml of a buffer with a pH of 6. The composite enzyme preparation is composed of 75% cellulase mass fraction, and the rest is pectinase.

[0026] After enzymolysis, heat and...

Embodiment 2

[0032] (1) Preparation of Fuyankang extract: Red peony root, Smilax glabra, Sanleng (in vinegar), Chuan neem (fried), Corydalis (Vinegar), Gorgon (stir-fried), Angelica, Sophora flavescens, Cyperus rotundus (Vinegar broiled), Phellodendron amurense and Salvia miltiorrhiza, according to the standard ingredients of Fuyankang tablets in the Pharmacopoeia of the People’s Republic of China, put the medicinal materials in the extraction tank, and add the enzymatic hydrolysate of 9 times the total mass of the medicinal materials in Enzymatic hydrolysis at 47°C for 3 hours.

[0033] The preparation method of the enzymolysis solution is as follows: dissolve 2.1 g of a composite enzyme preparation with an enzyme activity of 49,000 units in 500 ml of a buffer solution with a pH of 4.2. The composite enzyme preparation is composed of 52% cellulase mass fraction, and the rest is pectinase.

[0034] After enzymolysis, heat and reflux for extraction for 5.1 hours. In the reflux extraction proces...

Embodiment 3

[0040] (1) Preparation of Fuyankang extract: Red peony root, Smilax glabra, Sanleng (in vinegar), Chuan neem (fried), Corydalis (Vinegar), Gorgon (stir-fried), Angelica, Sophora flavescens, Cyperus rotundus (Vinegar broiled), Phellodendron amurense and Salvia miltiorrhiza, according to the standard ingredients of Fuyankang tablets in the Pharmacopoeia of the People’s Republic of China, put the medicinal materials in the extraction tank, and add the enzymatic hydrolysate of 3 times the total mass of the medicinal materials in the Enzymatic hydrolysis at 54°C for 4.5 hours.

[0041] The preparation method of the enzymolysis solution is as follows: 9.3 grams of a composite enzyme preparation with an enzyme activity of 12000 units is dissolved in 500 ml of a buffer solution with a pH value of 6.7. The composition of the composite enzyme preparation is 61% by mass fraction of cellulase, and the rest is pectinase.

[0042] After enzymolysis, heat and reflux for extraction for 2.3 hours,...

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Abstract

The invention discloses a Fuyankang particle and a production method thereof. The production method comprises the following steps: (1) preparing 11 traditional Chinese medicines required by production of a Fuyankang tablet according to Pharmacopoeia, enzymatically hydrolyzing the traditional Chinese medicines through a complex enzyme preparation, and implementing ultrasonic-assisted reflux extraction; (2) preparing yam and curcuma zedoary (stir-baked with vinegar) powder: drying yam and curcuma zedoary, and grinding the yam and the curcuma zedoary through a supersonic airflow pulverizing system and a cold pulp pulverizing system; (3) preparing a soft material: preparing the soft material through the yam powder and the curcuma zedoary (stir-baked with vinegar) powder and a Fuyankang extract; (4) preparing the particle: pelleting and drying the soft material. The production method disclosed by the invention, through enzymolysis by the complex enzyme preparation and the ultrasonic-assisted reflux extraction, can effectively shorten extraction time, improve an extraction rate of effective ingredients, in particular matrine, of the traditional Chinese medicines, and increase product quality and a percent of pass; by grinding the yam and the curcuma zedoary through the supersonic airflow pulverizing system and the cold pulp pulverizing system, the production method is good in a pulverizing effect, and can omit a sterilizing step.

Description

Technical field [0001] The invention relates to Fuyankang granules in the production process of traditional Chinese medicine Fuyankang tablets and a production method thereof. Background technique [0002] Extracting Chinese medicinal materials, concentrating the extracts to prepare extracts, preparing the extracts to make soft materials, and then making granules from soft materials is a necessary process for most Chinese medicine tablets, and Fuyankang tablets are not exception. [0003] Fuyankang tablets are made of red peony root, Smilax glabra, Sanleng (in vinegar), Chuan neem (stir-fried), Corydalis (stir-fried), Gorgon (stir-fried), Angelica, Sophora flavescens, Xiangfu (in vinegar), Cork The 11 kinds of Chinese herbal medicine pieces and Salvia miltiorrhiza were extracted with water in a certain proportion to prepare an extract, and then a certain proportion of Chinese herbal medicine pieces, yam and zedoary turmeric (vinegar broiled) were crushed into powder, and then the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K9/16A61K47/42A61P15/00
Inventor 周强胡江宇谢新平
Owner 兰州和盛堂制药股份有限公司
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