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Chitosan mouthwash and preparation method thereof
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A technology of chitosan and mouthwash, applied in the field of chitosan mouthwash and its preparation, can solve the problems of narrow antibacterial spectrum, single antibacterial effect, and unacceptable by patients
Active Publication Date: 2016-06-08
浙江康德药业集团股份有限公司
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Problems solved by technology
[0003] Before the present invention was made, products such as water-soluble chitosan mouthwash and tea polyphenol mouthwash had been used clinically. Synergy can achieve antibacterial effect, resulting in narrow antibacterial spectrum, poor use effect, poor taste, unacceptable by patients, etc., which makes it difficult to popularize and apply
Method used
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[0051] Preparation of chitosan mouthwash: take purified water, add chitosan, polylysine, natamycin, and aspartame, and heat to dissolve. After natural cooling, add essence and peppermint oil, add purified water to the full amount, and adjust the pH value to 6.5.
[0061] Preparation of chitosan mouthwash: take purified water, add chitosan, polylysine, natamycin, and aspartame, and heat to dissolve. After natural cooling, add essence and peppermint oil, add purified water to the full amount, and adjust the pH value to 6.5.
[0062] Clinical trial: the results show that the product of the embodiment can significantly reduce the number of bacteria in the oral cavity during clinical use and inhibit the growth of bacteria. The bacterial culture counts in the oral gingival crevicular fluid of the test subject before and after the test are statistically analyzed P<0.0001, with significant The overall effective rate of halitosis treatment is 94.00%, and the halitosis score before and ...
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Abstract
A chitosan mouthwash and a preparation method thereof are provided. Effective ingredients of the chitosan mouthwash comprise chitosan, natamycin, polylysine and aspartame, and the chitosan mouthwash also comprises mint oil, a lemon essence and purified water. The preparation method comprises the steps: taking purified water, adding chitosan, natamycin, polylysine and aspartame according to the amount, and heating to dissolve; after being cooled, adding the essence and the mint oil, additionally adding purified water to full amount of the mouthwash, determining the pH value, and thus obtaining the product. Compared with the prior art, because two broad-spectrum antibacterial agents of polylysine and natamycin are added into chitosan, the prepared mouthwash fully plays the advantages of the three kinds of drugs respectively in a bacteriostatic aspect.
Description
【Technical field】 [0001] The invention belongs to a chitosan mouthwash and a preparation method thereof. 【Background technique】 [0002] Oral disease is a common disease, mainly manifested as gingivitis, dental plaque, oral ulcers, periodontitis, aphtha of the mouth, bad breath and other symptoms. After the harmful bacteria produced by oral diseases enter the blood, they will have varying degrees of impact on the health of the whole body, and even become an important cause of some systemic diseases. Modern medical research shows that oral diseases are closely related to the endocrine system, cardiovascular system and respiratory system. For example: simulation experiments prove that streptococcus and periodontal pathogens enter blood vessels through wounds, which will promote the production of a gelatinous protein that acts like platelets, which can promote blood coagulation. This colloidal protein is attached to the blood vessel wall, and over time it will form coronary a...
Claims
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Application Information
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