A kind of preparation method of endotracheal tube with antibacterial adhesion

An anti-bacterial adhesion and endotracheal tube technology, applied in the direction of catheters, coatings, etc., can solve the problems of BCI difficult to treat, etc., and achieve the effect of long-lasting antibacterial effect, good anti-bacterial adhesion performance, and high chemical stability

Inactive Publication Date: 2015-08-12
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These factors make BF on the surface of PVC tracheal tube an important and continuous source of BCI pathogenic bacteria, making BCI difficult to treat effectively with drugs in clinical practice

Method used

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  • A kind of preparation method of endotracheal tube with antibacterial adhesion
  • A kind of preparation method of endotracheal tube with antibacterial adhesion
  • A kind of preparation method of endotracheal tube with antibacterial adhesion

Examples

Experimental program
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Effect test

preparation example Construction

[0030] 2. Preparation of iodine-containing photocatalytic antibacterial sol

[0031] Firstly, Ti(OH) was prepared by the traditional sol-gel method. 4 , Zn(OH)2 , Al(OH) 3 Sol, and then these sols and iodine compound solutions are mixed evenly, and then these mixed solutions are placed in a stainless steel high-pressure reaction kettle with a polytetrafluoroethylene lining and carried out airtight heat treatment at a certain temperature, and the treatment time is 12- 48h. The semiconductor composite oxide antibacterial sol containing different forms of iodine was prepared.

Embodiment 1

[0032] Example 1 Iodine-containing Ti(OH) 4 Sol preparation

[0033] Using tetrabutyl titanate as raw material, add the ethanol solution of tetrabutyl titanate dropwise to the aqueous solution under acidic conditions, and stir vigorously at room temperature for 24-36 h to obtain light blue Ti(OH) 4 Sol, the particle size distribution of the sol is 20-40 nm. Then, measure 1ml of an aqueous solution with a concentration of 1M potassium periodate and slowly add it dropwise to the Ti(OH) 4 sol, and then heat-treated in an autoclave at a temperature of 120-180°C for 12-30 h to obtain iodine-containing Ti(OH) 4 Sol antibacterial sol, denoted as I / Ti(OH) 4 .

Embodiment 2

[0034] Example 2 Iodine-containing Ti(OH) 4 -Al(OH) 3 Sol preparation

[0035] First, weigh 0.05mol of Al(NO) 3 Dissolve it in 100 ml deionized water, slowly add ammonia water dropwise under strong stirring at 40 °C to pH=8~9, and then stir at constant temperature for 3 h to obtain Al(OH) 3 Sol. Then, take 10ml Al(OH) 3 The sol was slowly added dropwise to 100ml Ti(OH) with vigorous stirring 4 Sol, after stirring evenly, according to Example 1, the iodine solution is mixed with the composite sol to obtain iodine-containing Ti(OH) 4 -Al(OH) 3 Mixed sol, denoted as I / Ti(OH) 4 -Al(OH) 3 .

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Abstract

The invention provides an endotracheal tube with long-acting bacterial adhesion prevention and a preparation method of the endotracheal tube. A surface chemical self-assembling method is adopted to carry out surface modification on a medical PVC endotracheal tube; by virtue of steps such as surface modification of the PVC endotracheal tube, synthesis of antibacterial sol, chemical reaction of a substrate surface and surface of antibacterial liquor, so that photocatalysis antibacterial components are uniformly and firmly loaded on the surface of the endotracheal tube to form a film, so that the surface-modified endotracheal tube has good bacterial adhesion prevention and visible-light induced sterilization performance, is lasting in antibacterial effect and high in chemical stability.

Description

Technical field [0001] The present invention is a medical polymer material field, which involves a tracheal duct and its preparation methods with long -acting antibacterial adhesion. Background technique [0002] Biomedical materials are important branches of material science. It has been widely used in many aspects such as artificial organs, surgical repair, physiotherapy rehabilitation, diagnosis, and treatment of diseases.The medical application of these materials has greatly promoted the rapid improvement of medical treatment, but also provides opportunities for bacterial invasive hosts.According to reports, the cases of biometric centers have increased year by year in recent years in recent years. The essence of study of biomass surface bacteria in recent years, and the development of new antibacterial biological materials has increasingly attracted people's attention. [0003] Among the many biomass, PVC plastic gas ducts are often used as respiratory channels for rescue of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/16C08J7/12C08J7/04
Inventor 林华香邓韦华王绪绪龙金林张子重林群
Owner FUZHOU UNIV
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