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SERS (Surface Enhanced Raman Scattering) substrate with self-assembled spherical array and preparation method thereof

A self-assembly and substrate technology, applied in the fields of biosensors and chemical analysis and detection, can solve the problems of cumbersome process and high cost, and achieve the effect of simplifying the process flow, saving costs, and having low equipment requirements.

Inactive Publication Date: 2014-07-23
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the problems of cumbersome process and high cost in the existing SERS substrate preparation process, and provide an effective and simple SERS substrate preparation method. The grain and gap structure formed during the plating process has a significant SERS enhancement effect

Method used

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  • SERS (Surface Enhanced Raman Scattering) substrate with self-assembled spherical array and preparation method thereof
  • SERS (Surface Enhanced Raman Scattering) substrate with self-assembled spherical array and preparation method thereof
  • SERS (Surface Enhanced Raman Scattering) substrate with self-assembled spherical array and preparation method thereof

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Effect test

Embodiment 1

[0036] Put the flat Si substrate into the prepared piranha lotion, take it out after ultrasonic treatment for 30 minutes, and rinse it with a large amount of deionized water. Afterwards, immerse the substrate in the mixed solution of ammonia water and hydrogen peroxide and continue ultrasonication for 40 minutes. After completion, take it out, wash it with a large amount of deionized water, and place it in the air to dry naturally. Microsphere solution, prepared as a solution with a concentration of w / v=0.5%, put it into an ultrasonic machine for 40 minutes and took it out; pipette 2ul polystyrene solution with a micropipette and drop it on the hydrophilic treated Si substrate On-chip, control the ambient temperature so that it can successfully complete independent self-assembly; the substrate after self-assembly is placed in an ion coating instrument, and the vacuum degree is controlled to 2×10 -2mbar, the ion current intensity is 10mA, and the evaporation time is selected as...

Embodiment 2

[0038] Put the flat Si substrate into the prepared piranha lotion, take it out after ultrasonic treatment for 30 minutes, and rinse it with a large amount of deionized water. Afterwards, immerse the substrate in the mixed solution of ammonia water and hydrogen peroxide and continue ultrasonication for 40 minutes. After completion, take it out, wash it with a large amount of deionized water, and place it in the air to dry naturally. Microsphere solution, prepared as a solution with a concentration of w / v=0.18%, placed in an ultrasonic machine for 50 minutes and then taken out; pipette 2ul polystyrene solution with a micropipette and drop it on the Si substrate treated with hydrophilic , control the temperature of the surrounding environment so that it can successfully complete independent self-assembly; the substrate after self-assembly is placed in an ion coating instrument, and the vacuum degree is controlled to be 2×10 -2 mbar, the ion current intensity is 10mA, and the evap...

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Abstract

The invention relates to an SERS (Surface Enhanced Raman Scattering) substrate with a self-assembled spherical array, wherein a compact nanoparticle array is arranged on a substrate which is subjected to cleaning and hydrophilic modification treatment to serve as a supporting layer of the SERS substrate, and then, an active noble metal thin film is evaporated on the supporting layer. The invention further provides a preparation method of the SERS substrate. The preparation method of the SERS substrate provided by the invention can fully use particles and interstitial structures formed on the flat and smooth substrate in the noble metal evaporating process, so that the preparation method is simple and feasible, has low equipment demand, saves cost, can provide very good Raman activity so as to provide a high probability of popularization and actual application of the SERS substrate.

Description

technical field [0001] The invention relates to a micro-nano processing method, more specifically, to a micro-nano processing method for preparing a SERS substrate by nanosphere self-assembly technology, and the method can be used in the fields of chemical analysis and detection, biosensors and the like. Background technique [0002] Surface-enhanced Raman scattering technology is a non-contact non-destructive detection technology that can provide single-molecule level information of the analyte, and has been rapidly developed and developed with the discovery and research of localized surface plasmon resonance (LSPR) phenomenon. . However, in recent decades, the application of SERS technology in real life has not been promoted as it should. The reason is that one of the big limiting factors is the cumbersome process and high cost of SERS active substrate preparation, and the high requirements for equipment during substrate preparation further hinder the application and prom...

Claims

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Application Information

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IPC IPC(8): C23C14/14C23C14/02G01N21/65B82Y40/00
Inventor 李康徐宗伟房丰洲林枫刘婷李云涛
Owner TIANJIN UNIV
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