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Preparation method and application of magnesium phosphate cement

A technology of magnesium phosphate bone cement and dihydrogen phosphate, which is applied in the field of medical biomaterial preparation, can solve the problems of high cost, long time consumption, high calcination temperature, etc., achieve good biocompatibility, facilitate growth, and simplify the batching process Effect

Inactive Publication Date: 2014-07-30
QINGHAI INST OF SALT LAKES OF CHINESE ACAD OF SCI +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the disadvantages of high calcination temperature, long time consumption and high cost in the preparation of magnesium phosphate bone cement in the prior art, and provide a simple and rapid method for preparing magnesium phosphate bone cement with low calcination temperature

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  • Preparation method and application of magnesium phosphate cement
  • Preparation method and application of magnesium phosphate cement
  • Preparation method and application of magnesium phosphate cement

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Embodiment 1

[0050] Firstly, the boron-containing magnesium oxide, a by-product of lithium extraction from salt lake, was calcined at 800°C for 3 hours, and then sintered MgO was produced after cooling, and then the sintered MgO was mixed with NaH 2 PO 4 According to the mass ratio of 1:1, the materials were mixed in a ball mill and ball milled for 60 minutes to make magnesium phosphate bone cement with a particle size ranging from 5 to 100 μm. When in use, add twice-distilled water as a solidification solution to the magnesium phosphate bone cement, the liquid-solid ratio is 0.5mL / g, and stir to obtain a uniform bone cement slurry, which can be used in bone repair operations.

Embodiment 2

[0052] Firstly, the boron-containing magnesium oxide, a by-product of lithium extraction from salt lake, was calcined at 900°C for 3 hours, and then sintered MgO was produced after cooling, and then the sintered MgO was mixed with NaH 2 PO 4 +NH 4 h 2 PO 4 According to the mass ratio of 2:1, the materials were mixed in a ball mill and ball milled for 50 minutes to make magnesium phosphate bone cement with a particle size ranging from 5 to 100 μm. When in use, add solidified liquid physiological saline to the magnesium phosphate bone cement, the liquid-solid ratio is 0.4mL / g, and stir to obtain a uniform bone cement slurry, which can be used in bone repair operations.

Embodiment 3

[0054] Firstly, the boron-containing magnesium oxide, a by-product of lithium extraction from salt lake, was calcined at 1000°C for 3 hours, and then sintered MgO was produced after cooling, and then the sintered MgO was mixed with KH 2 PO 4 According to the mass ratio of 3:1, the materials were mixed in a ball mill and ball milled for 40 minutes to make magnesium phosphate bone cement with a particle size ranging from 5 to 100 μm. When in use, add a glucose solution with a mass concentration of 0.9% solidified liquid into the magnesium phosphate bone cement, and the liquid-solid ratio is 0.1mL / g, and stir to obtain a uniform bone cement slurry, which can be used for bone repair operations.

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Abstract

The invention provides a preparation method of magnesium phosphate cement. The method comprises the following steps: using boron-containing magnesium oxide as an initial raw material, performing calcination on boron-containing magnesium oxide, cooling to obtain sintered MgO, mixing sintered MgO with dihydric phosphate, and performing ball-milling to obtain the magnesium phosphate cement. According to the method for preparing the magnesium phosphate cement, boron-containing magnesium oxide is used as the initial raw material, calcination and cooling are performed on the initial raw material to obtain sintered MgO, then mixing and ball-milling are performed on the sintered MgO and dihydric phosphate to obtain the magnesium phosphate cement. By regulating the calcination temperature of the initial raw material, the setting time and hydration exothermic temperature of MPC slurry can be regulated and controlled without adding extra setting retarders such as boric acid and borax, so that the blending process is simplified, the cost is reduced, and the interferences of other ions in the setting retarders to the inner environment of a human body are avoided.

Description

【Technical field】 [0001] The invention relates to the technical field of preparation of medical biological materials, in particular to a method for preparing magnesium phosphate bone cement and its application. 【Background technique】 [0002] Magnesium Phosphate Bone Cement (MPC) is mainly prepared by sintered magnesia, phosphate and retarder in a certain proportion. It has the characteristics of fast setting and high early strength. As early as 1945, Brookhaven Laboratory MPC is used as a quick repair material for buildings. As a type of inorganic adhesive, MPC is similar to calcium phosphate bone cement (CPC), which can solidify itself under the physiological environment of the human body. The hydration product is a phosphate biomineral, which has good biocompatibility. Years of research have shown that MPC has good biocompatibility and biodegradability, and is an ideal material for bone defect repair. [0003] The sintered MgO used by MPC in patents CN1307908A, CN144659...

Claims

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Application Information

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IPC IPC(8): C04B12/02A61L27/12
Inventor 董金美余红发谭永山
Owner QINGHAI INST OF SALT LAKES OF CHINESE ACAD OF SCI
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