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Superparamagnetic ferroferric oxide nano particle drug carrier, preparation method and application thereof

A technology of ferric tetroxide and nanoparticles, which can be used in pharmaceutical formulations, drug combinations, drug delivery, etc., can solve problems such as affecting drug efficacy, low bioavailability, and low solubility, so as to improve anticancer efficacy and overcome water solubility. poor sex effect

Inactive Publication Date: 2014-08-06
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, since artemisinin is insoluble in water, its solubility in common pharmaceutical solvents such as polyoxyethylene castor oil is not large, resulting in low bioavailability, which seriously affects its efficacy.

Method used

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  • Superparamagnetic ferroferric oxide nano particle drug carrier, preparation method and application thereof
  • Superparamagnetic ferroferric oxide nano particle drug carrier, preparation method and application thereof
  • Superparamagnetic ferroferric oxide nano particle drug carrier, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034]To prepare uniform carbon-coated iron ferric oxide nanoparticles, take 0.3g of ferrocene, dissolve it in 30.0mL of acetone, ultrasonically disperse it, then add 1.5ml of 30% hydrogen peroxide dropwise, and stir for 30 minutes. Transfer the solution to an autoclave with a capacity of 50ml, seal and heat to 210°C, keep it warm for 48h, then cool to room temperature to obtain a black powdery solid; then wash the sample 3 times with ethanol and distilled water to remove the residual Organic matter; then the sample is dried to obtain the product.

Embodiment 2

[0036] Preparation of carbon-coated iron ferric oxide nanoparticles with silver particles deposited on the surface, the carbon-coated iron ferric oxide nanoparticles prepared in Example 1 were dispersed in NN dimethylformamide solution, at 70 ° C Stir under conditions, then add 10ml of glucose in NN dimethylformamide solution (concentration is 0.05g / ml), continue stirring for 1h, add silver nitrate in the above solution in NN dimethylformamide solution (concentration is 0.01M ), the addition method is to add 2ml dropwise every 30min, and continue to react for 3h after the addition is complete; then wash the sample 3 times with ethanol and distilled water respectively, to remove residual organic matter in the solid powder; then dry the sample to obtain the product.

Embodiment 3

[0038] Preparation of silicon dioxide-coated surface deposited with porous carbon-coated iron ferric oxide nanoparticles of silver particles, the surface prepared by Example 2 is deposited with carbon-coated ferric oxide nanoparticles of silver particles Stir in an aqueous solution of cetyltrimethylammonium bromide (0,01M) at 50°C for 3 hours, then wash the sample once with distilled water and ethanol; disperse the washed sample in 40ml of ethanol solution, Add 2ml of ammonia water under the condition of ℃, stir for 30min, then add the ethanol solution of tetraethyl orthosilicate dropwise, and continue stirring at 50℃ for 12h; then wash the sample 3 times with ethanol and distilled water respectively.

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Abstract

The invention discloses a superparamagnetic ferroferric oxide nano particle drug carrier. The rug carrier comprises superparamagnetic ferroferric oxide nano particles which are formed by polymerizing ferroferric oxide nanocrystal with the size being smaller than 10nm and can release ferrous ion under an acidic condition, an amorphous carbon layer which is coated on the surface of the superparamagnetic ferroferric oxide nano particles and can be resolved in an alkaline condition, silver nano particles coated on the surface of the carbon layer, and a silicon dioxide layer, with a porous structure, coated on the surface of the silver nano particle. The drug carrier can load natural drug artemisinin, overcome the disadvantage of poor water solubility of artemisinin, and convey more artemisinin to a tumor focus part through intravenous injection, after the artemisinin reaches the tumor part, as tumor cell is in acid microenvironment, the drug carrier releases ferrous ion in the cell, the ferrous ion cracks peroxide bridges in the tumor, free radical is produced, protein, DNA (deoxyribonucleic acid) and cell membrane of the tumor cell are destroyed, finally the tumor cell is killed, and the anti-tumor efficacy of artemisinin is improved.

Description

technical field [0001] The invention belongs to the field of drug carriers, in particular to a porous nanoparticle synthesized by a chemical method, which has the functions of fluorescence imaging and magnetic resonance imaging, and has pH responsiveness, and can simultaneously load artemisinin anticancer drugs and provide Ferrous ions are used in tumor therapy. Background technique [0002] Cancer is one of the greatest disease threats facing human beings. Chemotherapy is still one of the main means of tumor treatment. Therefore, the research on new anti-tumor drugs has always been the focus of domestic and foreign pharmaceutical industry research and development. At present, the anticancer drugs widely used clinically are still artificially synthesized, and these drugs have great side effects while treating cancer. Although natural anticancer drugs have a long history of use, many natural products have been eliminated after entering clinical trials due to lack of efficacy...

Claims

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Application Information

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IPC IPC(8): A61K47/04A61K9/14A61K49/18A61K49/08A61K49/00A61K31/366A61P35/00
Inventor 陈乾旺陈健
Owner UNIV OF SCI & TECH OF CHINA
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