Lithium yttrium fluoride nanocomposite material, its preparation method, and its application in photodynamic therapy

A nanocomposite material and composite material technology are applied in the field of photosensitizer-coupled rare earth-doped yttrium-lithium fluoride nanocomposite materials and their preparation, and can solve the problems of low efficiency of nanoparticle sensitizer photosensitizer, complicated method, low yield and the like

Active Publication Date: 2014-08-13
FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the method of combining photosensitizers with nanomaterials is mainly to encapsulate photosensitizers with polymers or absorb photosensitizers with silica. Although the above methods can well couple photosensitizers

Method used

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  • Lithium yttrium fluoride nanocomposite material, its preparation method, and its application in photodynamic therapy
  • Lithium yttrium fluoride nanocomposite material, its preparation method, and its application in photodynamic therapy
  • Lithium yttrium fluoride nanocomposite material, its preparation method, and its application in photodynamic therapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Example 1: ZnPc-COOH coupling 8-nm LiYF 4 : Preparation of 0.20Yb / 0.02Er Nanocrystals

[0088] First weigh 0.1430g CF 3 COOLi, 0.3860g Y(CF 3 COO) 3 ,0.1132gYb(CF 3 COO) 3 and 0.0112g Er(CF 3 COO) 3 To a three-hole flask, then add 8mL oleic acid and 6mL oleylamine solvent. Then pass in N 2 Under certain conditions, the temperature was raised to 100°C and kept for 10 minutes to dissolve the solid reactants until transparent, and then heated to 320°C for 1 hour. After cooling down to room temperature, add 20mL ethanol for precipitation, centrifuge and wash to obtain 8nm oil-soluble LiYF 4 : 0.20Yb / 0.02Er nanocrystal. Disperse the nanocrystals in 15mL hydrochloric acid aqueous solution (0.1M) and sonicate for 15min, centrifuge to redisperse the obtained precipitate in dimethylformamide, add 3mg ZnPc-COOH and stir for 1h, centrifuge to obtain the precipitate, and disperse in water. After adding 20mg of PVP and stirring overnight, the precipitate obtained by centrif...

Embodiment 2

[0089] Example 2: ZnPc-COOH coupling 25-nm LiYF 4 : Preparation of 0.20Yb / 0.02Er Nanocrystals

[0090] First weigh 0.1430g CF 3 COOLi, 0.3860g Y(CF 3 COO) 3 ,0.1132gYb(CF 3 COO) 3 and 0.0112g Er(CF 3 COO) 3 To a three-hole flask, and then add 8mL oleic acid, 4mL oleylamine solvent. Then pass in N 2 Under certain conditions, the temperature was raised to 100°C and kept for 10 minutes to dissolve the solid reactants until transparent, and then heated to 320°C for 1 hour. After cooling down to room temperature, add 20mL ethanol to precipitate, centrifuge, and wash to obtain 20nm oil-soluble LiYF 4 : 0.20Yb / 0.02Er nanocrystal. Disperse the nanocrystals in 15mL hydrochloric acid aqueous solution (0.1M) and sonicate for 15min, then centrifuge to redisperse the obtained precipitate in dimethylformamide, add 3mg ZnPc-COOH and stir for 1h, then centrifuge the obtained precipitate to disperse in water, add After stirring 20mg of PVP overnight, the precipitate obtained by cent...

Embodiment 3

[0091] Example 3: ZnPc-COOH coupling 50-nm LiYF 4 : Preparation of 0.20Yb / 0.02Er Nanocrystals

[0092] First weigh 0.1430g CF 3 COOLi, 0.3860g Y(CF 3 COO) 3 ,0.1132gYb(CF 3 COO) 3 and 0.0112g Er(CF 3 COO) 3 To a three-hole flask, then add 8mL oleic acid and 2mL oleylamine solvent. Then pass in N 2 Under certain conditions, the temperature was raised to 100°C and kept for 10 minutes to dissolve the solid reactants until transparent, and then heated to 320°C for 1 hour. After cooling down to room temperature, add 20mL ethanol to precipitate, centrifuge, and wash to obtain 50nm oil-soluble LiYF 4 : 0.20Yb / 0.02Er nanocrystal. Disperse the nanocrystals in 15mL hydrochloric acid aqueous solution (0.1M) and sonicate for 15min, centrifuge the precipitate and redisperse it in dimethylformamide, add 3mg ZnPc-COOH and stir for 1h, centrifuge to disperse the precipitate in water, add 20mg After PVP was stirred overnight, the precipitate obtained by centrifugation was washed sev...

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PUM

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Abstract

The invention provides a photosensitizer coupled rare earth-doped LiAF4 nanocomposite material, its preparation method, and its application in the photodynamic therapy. The above photosensitizer coupled nanomaterial emits strong visible light under the irradiation of 980nm laser, and can sensitize the photosensitizer to generate singlet oxygen, so the nanomaterial can be used in the up-conversion photodynamic therapy. The method has the advantages of simplicity and high yield, the prepared nanomaterial has the advantages of good water solubility, excellent luminescence performance and high singlet oxygen yield, and the singlet oxygen can well kill cancer cells, so the nanomaterial can be applied in the diagnosis and treatment field of tumor diseases.

Description

technical field [0001] The invention relates to the field of rare earth doped nanocomposite materials, in particular to a photosensitizer coupled rare earth doped yttrium lithium fluoride nanocomposite material, a preparation method thereof and an application in the field of photodynamic therapy. Background technique [0002] In recent years, rare earth-doped upconversion nanomaterials have made great progress in controllable preparation, optical properties, and biological applications, but their combination with traditional photosensitizers as a new generation of photodynamic therapy materials has not attracted people's attention until recent years. focus on. Compared with the traditional photosensitizer materials excited by ultraviolet-visible light, due to the influence of the penetration depth of the excitation light source, they are greatly limited in the photodynamic therapy of some related tumors. The near-infrared-excited upconversion luminescent material combined w...

Claims

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Application Information

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IPC IPC(8): C09K11/85A61K41/00A61P35/00
Inventor 陈学元周山勇郑伟马恩黄明东陈卓涂大涛
Owner FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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