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Medicament for treatment of lung diseases and application thereof

A technology for pulmonary diseases and medicines, applied in the field of compositions containing guarene and/or aristolochne

Active Publication Date: 2014-09-17
ZHEJIANG MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the bronchodilation effect induced by bitter taste has been confirmed, but whether the mechanism of this effect is only through the opening of BK channels is still controversial

Method used

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  • Medicament for treatment of lung diseases and application thereof
  • Medicament for treatment of lung diseases and application thereof
  • Medicament for treatment of lung diseases and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: the preparation of guurrene, aristolochne

[0016] 1) After crushing 5kg of Guangfangji or Xugufeng dried whole herb, add water 4 times the mass of the medicinal material, heat in a steam distillation device at 100°C, and distill for 2 hours. It can be separated from the fractionation tube of the distillation device to obtain about Medicinal quality 0.9% essential oils of volatile oils. The obtained essential oil was dried and filtered with anhydrous sodium sulfate.

[0017] 2) Pack the column with 100-140 mesh silica gel by wet method, add dehydrated volatile oil with 25% weight of silica gel, elute with petroleum ether below 50°C, collect the eluent in turn, and check with thin layer chromatography to find out the olefin part in the volatile oil After removing to a trace amount, use ethyl acetate-petroleum ether (25:100→100:0) gradient elution instead, detect the chromatographic fractions by silica gel thin layer, collect every 20mL fractions, and use p...

Embodiment 2

[0018] Embodiment 2: anti-acute pneumonia drug efficacy test

[0019] 1 Materials and methods

[0020] 1.1 Animals and grouping

[0021] Clean-grade ICR mice, 18-22 g, were provided by the Experimental Animal Center of Zhejiang Province, animal production license number: SCXK (Zhejiang) 2014-0001. They were randomly divided into 6 groups according to their body weight: normal control group, model control group, dexamethasone group, guaranene group, aristolochne group and guaranene + aristolochne combined administration group, 10 rats in each group, Half and half male and half male, wherein guabrene and aristolochne were prepared by the method in Example 1.

[0022] 1.2 Model establishment and administration

[0023] Except for the normal control group which was given intravenous injection of the same dose of normal saline, the mice in the other groups were given tail vein injection of 5 mg / kg lipopolysaccharide (LPS). Oral administration was started 5 days before modeling....

Embodiment 3

[0042] Embodiment 3: anti-asthma efficacy test

[0043] 1 Experimental materials

[0044] Clean-grade Babl / c mice, half male and half female, 18-22 g, provided by Shanghai BK Company, animal license number: SCXK (Shanghai) 2013-0016.

[0045] Ovalbumin (batch number JS10710), Shanghai Jinsui Biotechnology Co., Ltd.; prednisone acetate (batch number: 120807), Zhejiang Xianju Pharmaceutical Co., Ltd.

[0046] 2 Experimental methods

[0047] 2.1 Model establishment and grouping

[0048] Babl / c mice were adaptively fed for 1 week and fed standard pelleted diet. Then they were divided into random groups, with 8 rats in each group, half male and half male. They were respectively set as normal control group, asthma model group, prednisone administration group, guacrene group, aristolochne group and guarrene + aristolochne combined administration group. Modeling method: Each mouse in the model group was sensitized by intraperitoneal injection of 0.2 mL PBS solution containing 20 ...

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Abstract

The invention discloses a medicament for the treatment of lung diseases and applications thereof and belong to the technical field of medicaments. The medicament contains more than one of gurjunene and aristolene extracted from fangchi roots or berba aristolochiae mollissimae. The invention provides a medicament for the treatment of lung diseases, the medicament has the pharmacological effects of treating lipopolysaccharide / chemicals-induced pulmonary edema and pneumonia, expanding bronchus, and reducing bronchial mucus secretion, and the like; in addition, the invention determines an application of the medicament for the treatment of lung diseases; particularly, the medicament can be used for treating acute pneumonia, asthma, pulmonary edema, or bronchitis.

Description

technical field [0001] The present invention relates to the use of the composition containing guarene and / or aristolochne, in particular to the application of the composition containing guarene and / or aristolochne in the preparation of medicines for treating lung diseases. Background technique [0002] Asthma is one of the most common diseases in the world today, and is listed as one of the four chronic diseases by the World Health Organization (WHO). Its main features are airway hyperresponsiveness and airway inflammation, which seriously threaten human health. In recent years, with the global air pollution and environmental deterioration, the morbidity and mortality of asthma have been increasing year by year. According to WHO estimates, there are as many as 300 million people with asthma in the world; in my country, the incidence of asthma has continued to increase in recent years, especially the prevalence of asthma in urban children has shown an obvious upward trend. ...

Claims

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Application Information

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IPC IPC(8): A61K31/015A61P11/00A61P31/00A61P29/00A61P11/06A61P11/08
Inventor 吴晓宁包启年余陈欢姚莹邓茂芳
Owner ZHEJIANG MEDICAL COLLEGE
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