Unlock instant, AI-driven research and patent intelligence for your innovation.

Application of cydiodine to treatment of otitis media

A technology of cydidinium iodine and inflammatory diseases, applied in the field of medicine, can solve the problems of limited therapeutic effect, insufficient blood supply to the inner ear, and easy to cause chronic otitis media.

Inactive Publication Date: 2014-09-24
BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD
View PDF5 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Smoking can cause systemic arteriosclerosis, especially when nicotine in cigarettes enters the blood, causing spasm of small blood vessels, increasing blood viscosity, and hardening of the arterioles that supply blood to the inner ear, resulting in insufficient blood supply to the inner ear and seriously affecting hearing
(6) Listening to rock music with large decibels with headphones for a long time can easily cause chronic otitis media if the time is long
[0018] However, the existing methods of using antibiotics still have many limitations, such as limited therapeutic effect

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of cydiodine to treatment of otitis media

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0075] Preparation example 1: the preparation of cediodine tablet

[0076] Formula (measured by the amount per tablet)

[0077] Cediodine: Contains 5 mg of available iodine (I),

[0078] Lactose: 50mg.

[0079] Preparation method: fully mix cediodine and lactose; put the mixed powder material on a stainless steel plate with a thickness of no more than one centimeter, and then place it in a sealed box with 75% ethanol saturated air for 18 hours ( Disposal at room temperature; when not specified in the present invention, it is the same); then the powder material is extruded into large pieces of flakes on an extruder (using a suitable large tablet press, the obtained thickness can be 0.5 ~2cm, large pieces with a diameter of 2~5cm, which is a conventional dry granulation method), and then the obtained flakes are broken into small particles (through a 18-mesh sieve), dried at 40-50°C, and pressed into tablets (the tablet is detected by gas chromatography, and no residual etha...

preparation example 2

[0084] Preparation example 2: the preparation of cediodine tablet

[0085] Formula (measured by the amount per tablet)

[0086] Cediodine: Contains 5 mg of available iodine (I),

[0087] Mannitol: 50mg.

[0088] Preparation method: fully mix cediiodine and mannitol; put the mixed powder material on a stainless steel plate with a thickness of no more than one centimeter, and place it in a sealed box saturated with 80% ethanol for 15 hours. (disposal at room temperature; when not specified in the present invention, it is all like this); then the powder material is extruded into a large tablet on an extruder (using a suitable large tablet press, the thickness can be obtained at 0.5-2cm, large pieces with a diameter of 2-5cm, which is a conventional dry granulation method), and then the resulting flakes are broken into small particles (through a 18-mesh sieve), dried at 40-50°C, and pressed into Tablet (this tablet detects according to gas chromatography, does not detect that...

preparation example 3

[0099] Preparation example 3: the preparation of cediodine tablet

[0100] Formula (measured by the amount per tablet)

[0101] Cediodine: Contains 5 mg of available iodine (I),

[0102] Lactose: 30mg.

[0103] Preparation method: fully mix cediodine and lactose; put the mixed powder material on a stainless steel plate with a thickness of no more than one centimeter, and place it in a sealed box saturated with 90% ethanol for 12 hours; Then prepare tablet according to the method of Preparation Example 1, this sample is denoted as Ex3. The surface tension of this tablet solution was 61.3 dyn / cm.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to an application of cydiodine to treatment of otitis media and particularly provides a solid pharmaceutical composition used to be dropped into ears. The solid pharmaceutical composition comprises cydiodine and a diluent, wherein the diluent is selected from glucose, mannitol, sorbitol, lactose, fructose, sodium chloride, saccharose and the like and a combination thereof. The invention also provides an application of the solid pharmaceutical composition to prevention and treatment of inflammatory diseases of ears, and a medicine box product comprising a packaging box, the solid pharmaceutical composition packaged in the packaging box and a solvent for dissolving the solid pharmaceutical composition. The solid pharmaceutical composition provided by the invention has an excellent effect for treating otitis media.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to the application of cediodine in treating otitis media. The present invention also provides a pharmaceutical composition for treating otitis media, which contains cediiodine. Using the composition of the invention to treat otitis media has excellent effect. Background technique [0002] It is known that iodine molecules can directly halogenate bacterial proteins, and non-selectively kill various microorganisms, including bacterial propagules, fungi, and spores. [0003] Many iodine preparations have been used clinically, such as povidone iodine and its preparations recorded in the Chinese Pharmacopoeia 2010 edition. The main dosage forms of antiseptics include creams, suppositories, solutions, and gels. [0004] Another example is the cediodine buccal tablets recorded in the 2010 edition of the Chinese Pharmacopoeia, which is used as a disinfectant and antiseptic drug. The active...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/18A61K47/48A61P27/16A61P31/04
CPCY02A50/30
Inventor 高永良陈登建闫汝锋汲守信王学智
Owner BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD