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Preparation method of emulsion for magnetic resonance imaging of lung

A technology of magnetic resonance imaging and emulsion, which is applied in preparations for in vivo tests, pharmaceutical formulations, emulsion delivery, etc., can solve the problems of preparation of no contrast agent, avoid inconvenience, reduce surface tension, and have good stability Effect

Inactive Publication Date: 2014-09-24
SHANGHAI JIAO TONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, no PS has been applied to the preparation of contrast agents

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] a. In 2000 parts of water by mass, add 1000 parts of Magnevist solution, after stirring, add 50 parts of dipalmitoylphosphatidylcholine, 5 parts of mPEG2000-DSPE, 20 parts of egg yolk lecithin, 10 parts of tyloxapol , 10 parts of cetyl alcohol, 10 parts of glycerin;

[0024] b. Stir magnetically at room temperature for 40 minutes until there are no obvious lumps;

[0025] c. Add 50 parts by mass of FC-77 to the emulsion obtained in b, and continue to stir for 40 minutes;

[0026] d. Stir the mixture obtained in c with a homogenizer intermittently for 1 hour at a stirring rate of 600r / min to 1000r / min, and then let it stand and centrifuge to remove the precipitate, and then the emulsion containing Magnevist can be obtained.

[0027] Test result: MRI test was carried out after dilution, the signal intensity was 5680; its surface tension was about 36mN / m.

Embodiment 2

[0029] a. In 2000 parts by mass of water, add 2000 parts of Magnevist solution, after stirring, add 80 parts of dipalmitoylphosphatidylcholine, 10 parts of mPEG4000-DSPE, 40 parts of egg yolk lecithin, 20 parts of hyaluronic acid , 20 parts of n-hexanol, 20 parts of glycerin;

[0030] b. Stir magnetically at room temperature for 80 minutes until there are no obvious lumps;

[0031] c. Add 80 parts by mass of FC-77 to the emulsion obtained in b, and continue to stir for 40 minutes;

[0032] d. Stir the mixed liquid obtained in c with a homogenizer intermittently for 3 hours at a stirring rate of 600r / min to 1000r / min, then let it stand and centrifuge to remove the precipitate, and then the emulsion containing Magnevist can be obtained.

[0033] Test results: After dilution, the magnetic resonance test was performed, and the signal intensity was 5376; the surface tension was about 33mN / m.

Embodiment 3

[0035] a. In water with 2000 parts by mass, add 4000 parts of Magnevist solution, after stirring, add 120 parts of dipalmitoylphosphatidylcholine, 20 parts of mPEG4000-DSPE, 50 parts of dioleoylphosphatidylcholine, 30 parts 1 part hyaluronic acid, 30 parts n-hexanol, 30 parts glycerin;

[0036]b. Stir magnetically at room temperature for 60 minutes until there are no obvious lumps;

[0037] c. Add 120 parts by mass of FC-77 to the emulsion obtained in b, and continue to stir for 30 minutes;

[0038] d. Stir the mixture obtained in c with a homogenizer intermittently for 2 hours at a stirring rate of 600r / min to 1000r / min, and then centrifuge to remove the precipitate, and then the emulsion containing Magnevist can be obtained.

[0039] Test results: The emulsion has the functions of stabilizing the airway, reducing the surface tension of the alveoli, and regulating the immune system. After dilution, the magnetic resonance test shows that the signal intensity is 5049; the surf...

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Abstract

The invention provides a preparation method of an emulsion for magnetic resonance imaging of lung. The preparation method of the emulsion for magnetic resonance imaging of the lung comprises the following specific steps: (1) adding a certain amount of magnevist solution into water, stirring and adding dipalmitoyl phosphatidyl choline, mPEG (polyethylene glycol)-DSPE (distearoyl phosphatidyl ethanolamine), phospholipid, surfactant, co-surfactant and stabilizer; (2) magnetically stirring at the room temperature till no obvious blocky substance is produced to obtain an emulsion; (3) adding pulmonary alveoli spreading agent into the emulsion and further stirring to obtain a mixed solution; (4) intermittently stirring the mixed solution by using a homogenizer, then standing, centrifuging and removing sediments to obtain an emulsion containing magnevist. The prepared emulsion for magnetic resonance imaging of lung is capable of entering the body through a pulmonary drug delivery way, avoiding a large quantity of inconveniences brought by parenteral drug delivery and meeting the requirements on a variety of clinical applications.

Description

technical field [0001] The invention relates to the field of preparation of nanomaterials, in particular to a method for preparing emulsion for lung magnetic resonance imaging. Background technique [0002] The lung is an open organ of the body. It has the following advantages as the administration site for protein and polypeptide drugs: it has a large absorption area. There are about 300-500 million alveoli in the whole lung, each alveoli diameter is about 250 μm, and the total area can reach 75-140m 2 ;The thickness between alveolar-capillary (can be divided into 5 layers: pulmonary surfactant, alveolar epithelium, interstitial tissue, capillary endothelial tissue and capillary basement membrane) is only 0.5mm, which is less than the thickness of general epithelial cell membrane and mucous membrane An order of magnitude allows macromolecular drugs to pass quickly; rich blood volume, up to 204-314mL / m for adults 2 , about 10% of the systemic circulation, and most of the a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/18A61K49/12A61K49/10
Inventor 姚燕杰刘恬朱君何丹农余震
Owner SHANGHAI JIAO TONG UNIV
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