Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of potassium aspartate tablet and preparation method thereof

A potassium aspartate tablet and a technology for potassium aspartate tablet are applied in the field of potassium aspartate tablet and its preparation, and can solve the problems of tablet splinter, poor compressibility, material moisture absorption and sticking, and the like, To achieve the effect of reducing hygroscopicity, reducing hygroscopicity, and improving splits

Active Publication Date: 2017-12-05
LIAONING YAOLIAN PHARMA
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The commonly used specification of potassium aspartate tablets is 0.3g, and the drug loading capacity is relatively large, but the raw material of potassium aspartate has strong hygroscopicity, and its compressibility is also poor, and the material is prone to moisture absorption during the tableting process Sticky punch, tablet split problem

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of potassium aspartate tablet and preparation method thereof
  • A kind of potassium aspartate tablet and preparation method thereof
  • A kind of potassium aspartate tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Prescription composition:

[0037]

[0038] Preparation:

[0039] (1) Binder configuration: weigh 30g of stearic acid, add it to 210g of ethanol (95%), heat to dissolve the stearic acid, and use it as a binder;

[0040] (2) Granulation: Weigh potassium aspartate and microcrystalline cellulose and mix evenly, add binder, stir evenly, and granulate with 18-mesh nylon screen; dry in a hot air circulation oven at 60°C for 4 hours; granules, add talcum powder and mix well;

[0041] (3) Tablet pressing: Use a rotary tablet press machine to press the tablet, the weight of the tablet is about 0.5g;

[0042] (4) Coating: Opadry (trade name, manufactured by Colorcon) was used for coating. Based on the plain tablet, the weight of the stomach-soluble moisture-proof coating increased by 3%.

[0043] In this example:

[0044] (1) The dosage of stearic acid in the tablet core formulation is 6%. Stearic acid is a hydrophobic material. After mixing with potassium aspartate, the s...

Embodiment 2

[0049] According to the method described in embodiment 1, utilize following prescription composition to prepare potassium aspartate tablet. Results Based on the plain tablet, the weight gain of the stomach-soluble moisture-proof coating was about 3%.

[0050] Prescription composition:

[0051]

Embodiment 3

[0053] According to the method described in embodiment 1, utilize following prescription composition to prepare potassium aspartate tablet. Results Based on the plain tablet, the weight gain of the stomach-soluble moisture-proof coating was about 3%.

[0054] Prescription composition:

[0055]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a potassium aspartate tablet and a preparation method thereof. The potassium aspartate tablet includes a tablet core and a coating, and the tablet core contains potassium aspartate and pharmaceutically acceptable auxiliary materials. The auxiliary materials include waxy auxiliary materials and other auxiliary materials. According to the percentage by weight, the preparation contains 30-90% of potassium aspartate and 0.5-20% of waxy auxiliary materials. The waxy excipients are one or more of glyceryl stearate, glyceryl monostearate, stearic acid, white wax, beeswax and stearyl alcohol. Compared with the potassium aspartate tablet without adding the above-mentioned auxiliary materials, the potassium aspartate tablet of the present invention in its preparation process, the hygroscopicity of the material is obviously reduced, the compressibility is obviously improved, the stability of the finished product is increased, and the Potassium aspartate tablet preparation difficulty and production cost.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a potassium aspartate tablet and a preparation method thereof. Background technique [0002] Potassium L-aspartate is a potassium supplement with the molecular formula C 4 h 6 KNO 4 1 / 2H 2 O, the structural formula is: [0003] [0004] Potassium is the main cation in cells, which is necessary for cell survival and has various physiological functions. 98% of the potassium is present in the cells, and the extracellular fluid contains only 2%. Potassium in the extracellular fluid mainly exists in the ion state. In addition to the ion state in the intracellular fluid, part of the potassium is combined with protein, and the other part is combined with sugar and phosphate. Potassium plays an important role in cell metabolism, maintenance of intracellular osmotic pressure, maintenance of intracellular acid-base balance, transmission of nerve impulses, mus...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/28A61K31/198A61K47/44A61K47/14A61K47/12A61K47/10A61P3/12
Inventor 于航
Owner LIAONING YAOLIAN PHARMA