Medicine for treating hyperacidity and preparation method thereof

A technology for hyperacidity and drugs, applied in drug combinations, active ingredients of aluminum/calcium/magnesium, digestive system, etc., can solve the problems of metronidazole with large side effects, unsuitable for long-term use, and unfavorable normal growth of children, etc. Mild effect of drug action

Inactive Publication Date: 2014-10-01
浙江康乐药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the medicines disclosed in the above-mentioned patent documents and the medicines for treating hyperacidity on the market are not suitable for children to take
In the technical scheme disclosed by Chinese Patent Publication No. CN 1135883A, the antibiotic metronidazole is used. Metronidazole has relatively large toxic and side effects, and is not suitable for children's administration or long-term use; Chinese Patent Publication No. CN 1150024A, China Patent Publication No. CN 1517098A, Application No. 201210001044.7, Application No. 201210388229.8 and other patent documents all use aluminum-containing compounds, and aluminum can cause children’s brain development to be retarded, which is not conducive to the normal growth of children. suitable for children

Method used

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  • Medicine for treating hyperacidity and preparation method thereof
  • Medicine for treating hyperacidity and preparation method thereof
  • Medicine for treating hyperacidity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh the raw and auxiliary materials of the following prescription quantities:

[0030]

[0031] Preparation:

[0032] (1) Grind each component in the formula into fine powders passing through an 80-mesh sieve; mix the formula amounts of calcium carbonate, heavy magnesium carbonate, magnesium trisilicate, sucrose, and microcrystalline cellulose evenly;

[0033] (2) Dissolve povidone in the prescribed amount in ethanol solution containing peppermint oil as a binder;

[0034] (3) Add the binder to the material obtained in step (1), mix evenly, pass through a 16-mesh sieve to granulate, boil and dry at 70°C for 5-45 minutes, and granulate with a 10-16 mesh sieve;

[0035] (4) Add talcum powder, magnesium stearate, and croscarmellose sodium in the prescribed amount to the premix prepared in step (3), and mix evenly to obtain drug granules for treating hyperacidity.

[0036] For the product quality standards and actual test results produced by the above-mentioned prepa...

Embodiment 2

[0039] Weigh the raw and auxiliary materials of the following prescription quantities:

[0040]

[0041] Preparation:

[0042] (1) Grind each component in the formula into a fine powder passing through an 80-mesh sieve; mix the calcium carbonate, heavy magnesium carbonate, magnesium trisilicate, sucrose, and corn starch in the formula amount evenly;

[0043] (2) Dissolve povidone in the prescribed amount in ethanol solution containing peppermint oil as a binder;

[0044] (3) Add the binder to the material obtained in step (1), mix evenly, pass through a 16-mesh sieve to granulate, boil and dry at 70°C for 5-45 minutes, and granulate with a 10-16 mesh sieve;

[0045] (4) Add talcum powder, stearic acid, and sodium carboxymethyl starch in prescribed amounts to the premix prepared in step (3), and mix evenly to obtain drug granules for treating hyperacidity.

[0046] For the product quality standards and actual test results produced by the above-mentioned preparation process...

Embodiment 3

[0049] Weigh the raw and auxiliary materials of the following prescription quantities:

[0050]

[0051] Preparation:

[0052] (1) Grind each component in the formula into a fine powder passing through an 80-mesh sieve; mix the calcium carbonate, heavy magnesium carbonate, magnesium trisilicate, and sucrose in the formula amount evenly;

[0053] (2) Dissolve povidone in the prescribed amount in ethanol solution containing peppermint oil as a binder;

[0054] (3) Add the binder to the material obtained in step (1), mix evenly, pass through a 16-mesh sieve to granulate, boil and dry at 70°C for 5-45 minutes, and granulate with a 10-16 mesh sieve;

[0055] (4) Add talcum powder, magnesium stearate, and croscarmellose sodium in the prescribed amount to the premix prepared in step (3), and mix evenly to obtain drug granules for treating hyperacidity.

[0056] For the product quality standards and actual test results produced by the above-mentioned preparation process:

[0057] ...

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Abstract

The invention discloses a medicine for treating hyperacidity and a preparation method thereof. The formula of the medicine comprises the following components in percentage by weight: 20-80wt% of main medicines including calcium carbonate, heavy magnesium carbonate and magnesium trisilicate, and the balance of accessories including a filler, a binder, a disintegrant and a lubricant. The medicine is mild and lasting in action, but has no direct inhibition effect on gastric acid secretion; the medicine for treating hyperacidity is suitable for the adults and also suitable for children to take.

Description

technical field [0001] The invention relates to a medicine for treating hyperacidity and a preparation method thereof. Background technique [0002] Hyperacidity in adults can cause clinical symptoms such as warm acidity, epigastric discomfort, epigastric pain, and / or heartburn. In recent years, this symptom has also had a relatively high incidence in children. With the development of medical science and technology, gastroscopy is widely used in children. In addition to indigestion, hyperacidity in children can still cause organic lesions in the upper gastrointestinal tract, such as reflux esophagitis, gastritis, twelve Enteritis and peptic ulcer, etc. According to data, 2.1% to 50% of peptic ulcers in adults come from childhood, so early treatment is necessary. [0003] Through retrieval, (1) Chinese patent publication number is CN 1135883A, a kind of gastrointestinal medicine and its preparation method. Its technical scheme is to crush and grind metronidazole into fine po...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/12A61P1/04A61P3/14
Inventor 张勇余泳华郑启敏陈长春张随楷
Owner 浙江康乐药业股份有限公司
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