A kind of sodium alginate microcapsules used in microwave hyperthermia technology for tumors and its preparation method and application

A technology of sodium alginate and microwave hyperthermia, which is used in microcapsules, capsule delivery, anti-tumor drugs, etc., can solve problems such as insufficient development and application, insufficient research on microwave hyperthermia, and difficulty in material selection. The effect of good clinical application value, improving diagnosis and treatment efficiency, and good treatment effect

Active Publication Date: 2017-03-08
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although microwave hyperthermia technology has the characteristics of non-invasive or minimally invasive and good safety, its huge potential has not been fully developed and applied at present, mainly because the research related to microwave hyperthermia is not in-depth, such as microwave sensitization. Difficult choice of material
In the past, materials such as magnetic nanoparticles used for hyperthermia in vivo have poor biocompatibility and have certain toxicity to organisms.

Method used

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  • A kind of sodium alginate microcapsules used in microwave hyperthermia technology for tumors and its preparation method and application
  • A kind of sodium alginate microcapsules used in microwave hyperthermia technology for tumors and its preparation method and application
  • A kind of sodium alginate microcapsules used in microwave hyperthermia technology for tumors and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] (1) Prepare core material solution:

[0047] Stir and dissolve sodium alginate in deionized water to obtain a 1wt% sodium alginate solution, add sodium chloride to the sodium alginate solution as a core material, the mass ratio of sodium chloride to sodium alginate is 1:10, and stir and disperse evenly ;

[0048] (2) emulsification step to form W / O emulsion:

[0049] Get the mixed solution of sodium alginate and sodium chloride obtained in step (1) into the conical flask, add liquid paraffin and emulsifier successively, the volume ratio of water phase to oil phase is 1:10, and the emulsifier used is Span80, and the emulsifier The volume fraction of 0.05%, magnetic stirring for 30 minutes to obtain a homogeneous milky white W / O emulsion;

[0050] (3) Microcapsule wall solidification step:

[0051] In the W / O emulsion obtained in step (2), calcium chloride was added as a solidifying agent, and magnetic stirring was performed for 30 minutes to form stable microcapsule w...

Embodiment 2

[0057] (1) Prepare core material solution:

[0058] Stir and dissolve sodium alginate in deionized water to obtain a 10wt% sodium alginate solution, add potassium chloride to the sodium alginate solution as a core material, the mass ratio of potassium chloride to sodium alginate is 1:5, and stir and disperse evenly ;

[0059] (2) emulsification step to form W / O emulsion:

[0060] Get the mixed solution of sodium alginate and potassium chloride obtained in step (1) into the conical flask, add liquid paraffin and emulsifier successively, the volume ratio of water phase and oil phase is 1:5, and the emulsifier used is Span80, emulsification The volume fraction of the agent was 0.5%, and the magnetic stirring was performed for 30 minutes to obtain a homogeneous milky white W / O emulsion;

[0061] (3) Microcapsule wall solidification step:

[0062] In the W / O emulsion obtained in step (2), calcium chloride was added as a solidifying agent, and magnetic stirring was performed for ...

Embodiment 3

[0068] (1) Prepare core material solution:

[0069] Stir and dissolve sodium alginate in deionized water to obtain a 5wt% sodium alginate solution, add ammonium chloride to the sodium alginate solution as a core material, the mass ratio of ammonium chloride to sodium alginate is 1:10, and stir and disperse evenly ;

[0070] (2) emulsification step to form W / O emulsion:

[0071] Get the mixed solution of sodium alginate and ammonium chloride obtained in step (1) into the conical flask, add liquid paraffin and emulsifier successively, the volume ratio of water phase and oil phase is 1:1, and the emulsifier used is Span80, and the emulsifier is The volume fraction of the agent was 0.1%, and the magnetic stirring was performed for 30 minutes to obtain a homogeneous milky white W / O emulsion;

[0072] (3) Microcapsule wall solidification step:

[0073] In the W / O emulsion obtained in step (2), calcium chloride was added as a solidifying agent, and magnetic stirring was performed ...

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Abstract

The invention discloses a sodium alginate microcapsule for tumor microwave hyperthermia technology. The diameter of the microcapsule is 1-10 microns, and the shell thickness of the microcapsule is 100-1000 nm. According to the invention, the sodium alginate microcapsule is firstly applied to the technical field of tumor microwave hyperthermia, and an excellent curative effect is obtained, so that the diagnosis and treatment efficiency is greatly improved, and an excellent clinical application value is provided.

Description

technical field [0001] The present invention relates to microcapsule technology and the field of biological application thereof. More specifically, it relates to a sodium alginate microcapsule used for tumor microwave hyperthermia technology and its preparation and application. Background technique [0002] Currently, cancer has become one of the major diseases that cause human death (Nanoscale, 2012, 4, 330-342, Nanoscale, 2013, 5, 12409-12424). According to the World Cancer Report 2014 by the World Health Organization, the number of cancer patients and deaths worldwide increased disturbingly in 2012, with more than 14 million new cases of cancer worldwide, increasing year by year to 19 million by 2025. It will reach 24 million by 2035. The report also shows that developing countries in Africa, Asia and Central and South America have the most severe cancer incidence. In 2012, there were 14 million new cancer cases and 8.2 million deaths worldwide. Among them, China adde...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K9/50A61K47/36A61P35/00
Inventor 孟宪伟史海堂付长慧任湘菱任俊
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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